A fluorescent nanoprobe for real-time monitoring of intracellular singlet oxygen during photodynamic therapy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-05

AUTHORS

Jian-tao Ping, Hong-shang Peng, Jinglei Qin, Fang-tian You, Yi-quan Wang, Gen-xiang Chen, Min Song

ABSTRACT

Sensing of intracellular singlet oxygen (1O2) is required in order to optimize photodynamic therapy (PDT). An optical nanoprobe is reported here for the optical determination of intracellular 1O2. The probe consists of a porous particle core doped with the commercial 1O2 probe 1,3-diphenylisobenzofuran (DPBF) and a layer of poly-L-lysine. The nanoparticle probes have a particle size of ~80 nm in diameter, exhibit good biocompatibility, improved photostability and high sensitivity for 1O2 in both absorbance (peak at 420 nm) and fluorescence (with excitation/emission peaks at 405/458 nm). Nanoprobes doped with 20% of DPBF are best suited even though they suffer from concentration quenching of fluorescence. In comparison with the commercial fluorescent 1O2 probe SOSG, 20%-doped DPBF-NPs (aged) shows higher sensitivity for 1O2 generated at an early stage. The best nanoprobes were used to real-time monitor the PDT-triggered generation of 1O2 inside live cells, and the generation rate is found to depend on the supply of intracellular oxygen. Graphical abstract A fluorescent nanoprobe featured with refined selectivity and improved sensitivity towards 1O2 was prepared from the absorption-based probe DBPF and used to real-time monitoring of the generation of intracellular 1O2 produced during PDT. More... »

PAGES

269

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00604-018-2815-5

DOI

http://dx.doi.org/10.1007/s00604-018-2815-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103665251

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29700623


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0205", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Optical Physics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/02", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Physical Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Ministry of Education of the People's Republic of China", 
          "id": "https://www.grid.ac/institutes/grid.419897.a", 
          "name": [
            "School of Science, Minzu University of China, 100081, Beijing, China", 
            "Key Laboratory of Luminescence and Optical Information, Ministry of Education, Institute of Optoelectronic Technology, Beijing Jiaotong University, 100044, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ping", 
        "givenName": "Jian-tao", 
        "id": "sg:person.01075016573.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075016573.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Minzu University of China", 
          "id": "https://www.grid.ac/institutes/grid.411077.4", 
          "name": [
            "School of Science, Minzu University of China, 100081, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Peng", 
        "givenName": "Hong-shang", 
        "id": "sg:person.01155671522.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155671522.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Minzu University of China", 
          "id": "https://www.grid.ac/institutes/grid.411077.4", 
          "name": [
            "School of Science, Minzu University of China, 100081, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Qin", 
        "givenName": "Jinglei", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ministry of Education of the People's Republic of China", 
          "id": "https://www.grid.ac/institutes/grid.419897.a", 
          "name": [
            "Key Laboratory of Luminescence and Optical Information, Ministry of Education, Institute of Optoelectronic Technology, Beijing Jiaotong University, 100044, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "You", 
        "givenName": "Fang-tian", 
        "id": "sg:person.07614655003.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07614655003.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Minzu University of China", 
          "id": "https://www.grid.ac/institutes/grid.411077.4", 
          "name": [
            "School of Science, Minzu University of China, 100081, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Yi-quan", 
        "id": "sg:person.015564564017.88", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015564564017.88"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Minzu University of China", 
          "id": "https://www.grid.ac/institutes/grid.411077.4", 
          "name": [
            "School of Science, Minzu University of China, 100081, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chen", 
        "givenName": "Gen-xiang", 
        "id": "sg:person.01260153205.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260153205.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Minzu University of China", 
          "id": "https://www.grid.ac/institutes/grid.411077.4", 
          "name": [
            "School of Science, Minzu University of China, 100081, Beijing, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Song", 
        "givenName": "Min", 
        "id": "sg:person.012017217043.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012017217043.59"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1039/c5sc03583j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000730081"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2760(91)90304-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001767058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0005-2760(91)90304-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001767058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jbbm.2005.10.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001825124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jbbm.2005.10.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001825124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jo500219y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005159275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.201405048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013310468"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jxb/erj181", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017475945"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10895-012-1114-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021008936", 
          "https://doi.org/10.1007/s10895-012-1114-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/f29726800586", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021481701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c6cs00192k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023207151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c6tb00307a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026293849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1751-1097.2011.00900.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029421280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ange.201405048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034432619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/b822776d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034769495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/b822776d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034769495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/b9pp00004f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035361217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/b9pp00004f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035361217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c4cs00294f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037884573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1562/0031-8655(2002)0750382dnildo2.0.co2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039241954"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1071", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039940247", 
          "https://doi.org/10.1038/nrc1071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc1071", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039940247", 
          "https://doi.org/10.1038/nrc1071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbcan.2012.10.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041104723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0891-5849(00)00460-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043537882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja504279r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044278929"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jp406638g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044748759"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c2tb00350c", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044981157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c6cc05880a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047724430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cr900300p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049031156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/cr900300p", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049031156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.trac.2016.09.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049705764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10555-007-9055-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049789382", 
          "https://doi.org/10.1007/s10555-007-9055-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10555-007-9055-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049789382", 
          "https://doi.org/10.1007/s10555-007-9055-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/lapl.200810116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050431680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jlumin.2011.05.048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053575964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ar010086g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055149570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ar010086g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055149570"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja807484b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055859725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ja807484b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055859725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jp206739y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056084870"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ol401421r", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056254701"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anie.201609050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083405434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ange.201609050", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083528503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acsami.7b02034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084852059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acs.langmuir.7b00522", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084864237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c7pp00132k", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091407990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c7tb02684f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092546308"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-05", 
    "datePublishedReg": "2018-05-01", 
    "description": "Sensing of intracellular singlet oxygen (1O2) is required in order to optimize photodynamic therapy (PDT). An optical nanoprobe is reported here for the optical determination of intracellular 1O2. The probe consists of a porous particle core doped with the commercial 1O2 probe 1,3-diphenylisobenzofuran (DPBF) and a layer of poly-L-lysine. The nanoparticle probes have a particle size of ~80\u00a0nm in diameter, exhibit good biocompatibility, improved photostability and high sensitivity for 1O2 in both absorbance (peak at 420\u00a0nm) and fluorescence (with excitation/emission peaks at 405/458\u00a0nm). Nanoprobes doped with 20% of DPBF are best suited even though they suffer from concentration quenching of fluorescence. In comparison with the commercial fluorescent 1O2 probe SOSG, 20%-doped DPBF-NPs (aged) shows higher sensitivity for 1O2 generated at an\u00a0early stage. The best nanoprobes were used to real-time monitor the PDT-triggered generation of 1O2 inside live cells, and the generation rate is found to depend on the supply of intracellular oxygen. Graphical abstract A fluorescent nanoprobe featured with refined selectivity and improved sensitivity towards 1O2 was prepared from\u00a0the absorption-based probe DBPF and used to real-time monitoring of the generation of intracellular 1O2 produced during PDT.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00604-018-2815-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1009468", 
        "issn": [
          "0026-3672", 
          "1436-5073"
        ], 
        "name": "Microchimica Acta", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "185"
      }
    ], 
    "name": "A fluorescent nanoprobe for real-time monitoring of intracellular singlet oxygen during photodynamic therapy", 
    "pagination": "269", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c24508e442c5698b9036bc7db5de2392bb18237f03a8105d32d14ff3d2751f02"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29700623"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7808782"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00604-018-2815-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1103665251"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00604-018-2815-5", 
      "https://app.dimensions.ai/details/publication/pub.1103665251"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T02:14", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000535.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs00604-018-2815-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00604-018-2815-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00604-018-2815-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00604-018-2815-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00604-018-2815-5'


 

This table displays all metadata directly associated to this object as RDF triples.

231 TRIPLES      21 PREDICATES      67 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00604-018-2815-5 schema:about anzsrc-for:02
2 anzsrc-for:0205
3 schema:author N94c03ac763894330bea7ed390f35664e
4 schema:citation sg:pub.10.1007/s10555-007-9055-1
5 sg:pub.10.1007/s10895-012-1114-5
6 sg:pub.10.1038/nrc1071
7 https://doi.org/10.1002/ange.201405048
8 https://doi.org/10.1002/ange.201609050
9 https://doi.org/10.1002/anie.201405048
10 https://doi.org/10.1002/anie.201609050
11 https://doi.org/10.1002/lapl.200810116
12 https://doi.org/10.1016/0005-2760(91)90304-z
13 https://doi.org/10.1016/j.bbcan.2012.10.001
14 https://doi.org/10.1016/j.jbbm.2005.10.003
15 https://doi.org/10.1016/j.jlumin.2011.05.048
16 https://doi.org/10.1016/j.trac.2016.09.006
17 https://doi.org/10.1016/s0891-5849(00)00460-3
18 https://doi.org/10.1021/acs.langmuir.7b00522
19 https://doi.org/10.1021/acsami.7b02034
20 https://doi.org/10.1021/ar010086g
21 https://doi.org/10.1021/cr900300p
22 https://doi.org/10.1021/ja504279r
23 https://doi.org/10.1021/ja807484b
24 https://doi.org/10.1021/jo500219y
25 https://doi.org/10.1021/jp206739y
26 https://doi.org/10.1021/jp406638g
27 https://doi.org/10.1021/ol401421r
28 https://doi.org/10.1039/b822776d
29 https://doi.org/10.1039/b9pp00004f
30 https://doi.org/10.1039/c2tb00350c
31 https://doi.org/10.1039/c4cs00294f
32 https://doi.org/10.1039/c5sc03583j
33 https://doi.org/10.1039/c6cc05880a
34 https://doi.org/10.1039/c6cs00192k
35 https://doi.org/10.1039/c6tb00307a
36 https://doi.org/10.1039/c7pp00132k
37 https://doi.org/10.1039/c7tb02684f
38 https://doi.org/10.1039/f29726800586
39 https://doi.org/10.1093/jxb/erj181
40 https://doi.org/10.1111/j.1751-1097.2011.00900.x
41 https://doi.org/10.1562/0031-8655(2002)0750382dnildo2.0.co2
42 schema:datePublished 2018-05
43 schema:datePublishedReg 2018-05-01
44 schema:description Sensing of intracellular singlet oxygen (<sup>1</sup>O<sub>2</sub>) is required in order to optimize photodynamic therapy (PDT). An optical nanoprobe is reported here for the optical determination of intracellular <sup>1</sup>O<sub>2</sub>. The probe consists of a porous particle core doped with the commercial <sup>1</sup>O<sub>2</sub> probe 1,3-diphenylisobenzofuran (DPBF) and a layer of poly-L-lysine. The nanoparticle probes have a particle size of ~80 nm in diameter, exhibit good biocompatibility, improved photostability and high sensitivity for <sup>1</sup>O<sub>2</sub> in both absorbance (peak at 420 nm) and fluorescence (with excitation/emission peaks at 405/458 nm). Nanoprobes doped with 20% of DPBF are best suited even though they suffer from concentration quenching of fluorescence. In comparison with the commercial fluorescent <sup>1</sup>O<sub>2</sub> probe SOSG, 20%-doped DPBF-NPs (aged) shows higher sensitivity for <sup>1</sup>O<sub>2</sub> generated at an early stage. The best nanoprobes were used to real-time monitor the PDT-triggered generation of <sup>1</sup>O<sub>2</sub> inside live cells, and the generation rate is found to depend on the supply of intracellular oxygen. Graphical abstract A fluorescent nanoprobe featured with refined selectivity and improved sensitivity towards <sup>1</sup>O<sub>2</sub> was prepared from the absorption-based probe DBPF and used to real-time monitoring of the generation of intracellular <sup>1</sup>O<sub>2</sub> produced during PDT.
45 schema:genre research_article
46 schema:inLanguage en
47 schema:isAccessibleForFree false
48 schema:isPartOf N1296e7d4c0f049a8805b6bcf520e8792
49 Nba28887e3ea94b5db6f2ed14bceb9cbd
50 sg:journal.1009468
51 schema:name A fluorescent nanoprobe for real-time monitoring of intracellular singlet oxygen during photodynamic therapy
52 schema:pagination 269
53 schema:productId N09bcc29079b144e5a36a92c4a2c7ba53
54 N6fafe6d164da42b19690592556ce15a4
55 N808ebacbd47a45999875e157537c89fa
56 Na87664c1a78d4380911692fd5dd5cf77
57 Ne400fd7ccfe84edda463ca6b86f53f3f
58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103665251
59 https://doi.org/10.1007/s00604-018-2815-5
60 schema:sdDatePublished 2019-04-11T02:14
61 schema:sdLicense https://scigraph.springernature.com/explorer/license/
62 schema:sdPublisher Ncfeb3095701746b5b1aa81bc03fc6895
63 schema:url http://link.springer.com/10.1007%2Fs00604-018-2815-5
64 sgo:license sg:explorer/license/
65 sgo:sdDataset articles
66 rdf:type schema:ScholarlyArticle
67 N07855f3851d6472492b6a7d390cd5603 rdf:first sg:person.01155671522.44
68 rdf:rest N4512b9894dff426b948b394afa43cff0
69 N09bcc29079b144e5a36a92c4a2c7ba53 schema:name pubmed_id
70 schema:value 29700623
71 rdf:type schema:PropertyValue
72 N1296e7d4c0f049a8805b6bcf520e8792 schema:issueNumber 5
73 rdf:type schema:PublicationIssue
74 N28b5e5c5ba634eeb9be2729bfb9ead2f schema:affiliation https://www.grid.ac/institutes/grid.411077.4
75 schema:familyName Qin
76 schema:givenName Jinglei
77 rdf:type schema:Person
78 N322a9e98673349c49ae786fe5a733a01 rdf:first sg:person.015564564017.88
79 rdf:rest N60f28aec94c04e2d979bbf14ce9e14e6
80 N4512b9894dff426b948b394afa43cff0 rdf:first N28b5e5c5ba634eeb9be2729bfb9ead2f
81 rdf:rest N86c20f8a71fa41ee8fc5790d88c36b26
82 N484230e1080f466687ccd6971872f5e1 rdf:first sg:person.012017217043.59
83 rdf:rest rdf:nil
84 N60f28aec94c04e2d979bbf14ce9e14e6 rdf:first sg:person.01260153205.10
85 rdf:rest N484230e1080f466687ccd6971872f5e1
86 N6fafe6d164da42b19690592556ce15a4 schema:name nlm_unique_id
87 schema:value 7808782
88 rdf:type schema:PropertyValue
89 N808ebacbd47a45999875e157537c89fa schema:name doi
90 schema:value 10.1007/s00604-018-2815-5
91 rdf:type schema:PropertyValue
92 N86c20f8a71fa41ee8fc5790d88c36b26 rdf:first sg:person.07614655003.52
93 rdf:rest N322a9e98673349c49ae786fe5a733a01
94 N94c03ac763894330bea7ed390f35664e rdf:first sg:person.01075016573.52
95 rdf:rest N07855f3851d6472492b6a7d390cd5603
96 Na87664c1a78d4380911692fd5dd5cf77 schema:name readcube_id
97 schema:value c24508e442c5698b9036bc7db5de2392bb18237f03a8105d32d14ff3d2751f02
98 rdf:type schema:PropertyValue
99 Nba28887e3ea94b5db6f2ed14bceb9cbd schema:volumeNumber 185
100 rdf:type schema:PublicationVolume
101 Ncfeb3095701746b5b1aa81bc03fc6895 schema:name Springer Nature - SN SciGraph project
102 rdf:type schema:Organization
103 Ne400fd7ccfe84edda463ca6b86f53f3f schema:name dimensions_id
104 schema:value pub.1103665251
105 rdf:type schema:PropertyValue
106 anzsrc-for:02 schema:inDefinedTermSet anzsrc-for:
107 schema:name Physical Sciences
108 rdf:type schema:DefinedTerm
109 anzsrc-for:0205 schema:inDefinedTermSet anzsrc-for:
110 schema:name Optical Physics
111 rdf:type schema:DefinedTerm
112 sg:journal.1009468 schema:issn 0026-3672
113 1436-5073
114 schema:name Microchimica Acta
115 rdf:type schema:Periodical
116 sg:person.01075016573.52 schema:affiliation https://www.grid.ac/institutes/grid.419897.a
117 schema:familyName Ping
118 schema:givenName Jian-tao
119 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075016573.52
120 rdf:type schema:Person
121 sg:person.01155671522.44 schema:affiliation https://www.grid.ac/institutes/grid.411077.4
122 schema:familyName Peng
123 schema:givenName Hong-shang
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155671522.44
125 rdf:type schema:Person
126 sg:person.012017217043.59 schema:affiliation https://www.grid.ac/institutes/grid.411077.4
127 schema:familyName Song
128 schema:givenName Min
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012017217043.59
130 rdf:type schema:Person
131 sg:person.01260153205.10 schema:affiliation https://www.grid.ac/institutes/grid.411077.4
132 schema:familyName Chen
133 schema:givenName Gen-xiang
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01260153205.10
135 rdf:type schema:Person
136 sg:person.015564564017.88 schema:affiliation https://www.grid.ac/institutes/grid.411077.4
137 schema:familyName Wang
138 schema:givenName Yi-quan
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015564564017.88
140 rdf:type schema:Person
141 sg:person.07614655003.52 schema:affiliation https://www.grid.ac/institutes/grid.419897.a
142 schema:familyName You
143 schema:givenName Fang-tian
144 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07614655003.52
145 rdf:type schema:Person
146 sg:pub.10.1007/s10555-007-9055-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049789382
147 https://doi.org/10.1007/s10555-007-9055-1
148 rdf:type schema:CreativeWork
149 sg:pub.10.1007/s10895-012-1114-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021008936
150 https://doi.org/10.1007/s10895-012-1114-5
151 rdf:type schema:CreativeWork
152 sg:pub.10.1038/nrc1071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039940247
153 https://doi.org/10.1038/nrc1071
154 rdf:type schema:CreativeWork
155 https://doi.org/10.1002/ange.201405048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034432619
156 rdf:type schema:CreativeWork
157 https://doi.org/10.1002/ange.201609050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083528503
158 rdf:type schema:CreativeWork
159 https://doi.org/10.1002/anie.201405048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013310468
160 rdf:type schema:CreativeWork
161 https://doi.org/10.1002/anie.201609050 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083405434
162 rdf:type schema:CreativeWork
163 https://doi.org/10.1002/lapl.200810116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050431680
164 rdf:type schema:CreativeWork
165 https://doi.org/10.1016/0005-2760(91)90304-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1001767058
166 rdf:type schema:CreativeWork
167 https://doi.org/10.1016/j.bbcan.2012.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041104723
168 rdf:type schema:CreativeWork
169 https://doi.org/10.1016/j.jbbm.2005.10.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001825124
170 rdf:type schema:CreativeWork
171 https://doi.org/10.1016/j.jlumin.2011.05.048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053575964
172 rdf:type schema:CreativeWork
173 https://doi.org/10.1016/j.trac.2016.09.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049705764
174 rdf:type schema:CreativeWork
175 https://doi.org/10.1016/s0891-5849(00)00460-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043537882
176 rdf:type schema:CreativeWork
177 https://doi.org/10.1021/acs.langmuir.7b00522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084864237
178 rdf:type schema:CreativeWork
179 https://doi.org/10.1021/acsami.7b02034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084852059
180 rdf:type schema:CreativeWork
181 https://doi.org/10.1021/ar010086g schema:sameAs https://app.dimensions.ai/details/publication/pub.1055149570
182 rdf:type schema:CreativeWork
183 https://doi.org/10.1021/cr900300p schema:sameAs https://app.dimensions.ai/details/publication/pub.1049031156
184 rdf:type schema:CreativeWork
185 https://doi.org/10.1021/ja504279r schema:sameAs https://app.dimensions.ai/details/publication/pub.1044278929
186 rdf:type schema:CreativeWork
187 https://doi.org/10.1021/ja807484b schema:sameAs https://app.dimensions.ai/details/publication/pub.1055859725
188 rdf:type schema:CreativeWork
189 https://doi.org/10.1021/jo500219y schema:sameAs https://app.dimensions.ai/details/publication/pub.1005159275
190 rdf:type schema:CreativeWork
191 https://doi.org/10.1021/jp206739y schema:sameAs https://app.dimensions.ai/details/publication/pub.1056084870
192 rdf:type schema:CreativeWork
193 https://doi.org/10.1021/jp406638g schema:sameAs https://app.dimensions.ai/details/publication/pub.1044748759
194 rdf:type schema:CreativeWork
195 https://doi.org/10.1021/ol401421r schema:sameAs https://app.dimensions.ai/details/publication/pub.1056254701
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1039/b822776d schema:sameAs https://app.dimensions.ai/details/publication/pub.1034769495
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1039/b9pp00004f schema:sameAs https://app.dimensions.ai/details/publication/pub.1035361217
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1039/c2tb00350c schema:sameAs https://app.dimensions.ai/details/publication/pub.1044981157
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1039/c4cs00294f schema:sameAs https://app.dimensions.ai/details/publication/pub.1037884573
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1039/c5sc03583j schema:sameAs https://app.dimensions.ai/details/publication/pub.1000730081
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1039/c6cc05880a schema:sameAs https://app.dimensions.ai/details/publication/pub.1047724430
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1039/c6cs00192k schema:sameAs https://app.dimensions.ai/details/publication/pub.1023207151
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1039/c6tb00307a schema:sameAs https://app.dimensions.ai/details/publication/pub.1026293849
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1039/c7pp00132k schema:sameAs https://app.dimensions.ai/details/publication/pub.1091407990
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1039/c7tb02684f schema:sameAs https://app.dimensions.ai/details/publication/pub.1092546308
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1039/f29726800586 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021481701
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1093/jxb/erj181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017475945
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1111/j.1751-1097.2011.00900.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1029421280
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1562/0031-8655(2002)0750382dnildo2.0.co2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039241954
224 rdf:type schema:CreativeWork
225 https://www.grid.ac/institutes/grid.411077.4 schema:alternateName Minzu University of China
226 schema:name School of Science, Minzu University of China, 100081, Beijing, China
227 rdf:type schema:Organization
228 https://www.grid.ac/institutes/grid.419897.a schema:alternateName Ministry of Education of the People's Republic of China
229 schema:name Key Laboratory of Luminescence and Optical Information, Ministry of Education, Institute of Optoelectronic Technology, Beijing Jiaotong University, 100044, Beijing, China
230 School of Science, Minzu University of China, 100081, Beijing, China
231 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...