Multiple carcinoids of the duodenum accompanied by type I familial multiple endocrine neoplasia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1998-06

AUTHORS

Kazuyuki Yazawa, Takai Kuroda, Hiroyuki Watanabe, Nobuhiko Shimozawa, Yoshinori Nimura, Shinji Nakata, Yoshiro Fujimori, Naohiko Koide, Shoichiro Koike, Shoji Kajikawa, Wataru Adachi, Shinya Kobayashi, Keiko Ishii, Jun Amano

ABSTRACT

A case of multiple carcinoid tumors of the duodenum accompanied by familial multiple endocrine neoplasia is reported. A 46-year-old man with duodenal polyps discovered during a mass screening was followed up for 5 years. In August 1994, a histological examination revealed carcinoid tumors, and he was thus referred to our hospital for surgery. He underwent a parathyroidectomy and cholecystectomy for primary hyperparathyroidism and cholecystolithiasis, respectively. The patient's sister had also undergone a parathyroidectomy and distal pancreatectomy for primary hyperparathyroidism and insulinoma of the pancreas. In addition, his two children were also followed up for hypercalcemia. A serum examination of the patient revealed high levels of somatostatin and pancreatic polypeptide, but normal levels of gastrin and serotonin. In November 1994, a pancreaticoduodenectomy with a D2 lymph node dissection was performed. The macroscopic findings of the resected specimen showed multiple polypoid lesions with delles on the top, measuring 3 to 15 mm in size throughout the duodenum. A microscopic examination revealed the tumor to have infiltrated into the submucosa extensively, and an immunohistochemical analysis also demonstrated the tumor cells to be positive for somatostatin, but not for pancreatic polypeptide. After surgery, the serum level of somatostatin returned to normal but the pancreatic polypeptide remained high. The post-operative course was uneventful, and the patient remains in good health. More... »

PAGES

636-639

References to SciGraph publications

  • 1986-09. Duodenal and ampullary carcinoid tumors in VIRCHOWS ARCHIV A PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY
  • 1978-03. Jejunal endocrine tumour composed of somatostatin and gastrin cells and associated with duodenal ulcer disease in VIRCHOWS ARCHIV A PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s005950050197

    DOI

    http://dx.doi.org/10.1007/s005950050197

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1028925822

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/9681614


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