Etiologies and treatments of chronic intestinal failure-short bowel syndrome (SBS) in Japanese adults: a real-world observational study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-02-23

AUTHORS

Tsunekazu Mizushima, Eri Udagawa, Miyuki Hasegawa, Yuko Tazuke, Hiroomi Okuyama, Jovelle Fernandez, Shiro Nakamura

ABSTRACT

PurposeShort bowel syndrome (SBS) with intestinal failure (SBS-IF) requires long-term parenteral nutrition (PN). This study investigated the real-world etiologies of SBS, treatment patterns, and PN-related outcomes among adult patients with SBS-IF in Japan.MethodsThis retrospective, observational cohort study was based on data from April, 2008 to January, 2020 from one of the largest hospital-based claim databases in Japan. Analyzed patients were aged ≥ 16 years, had received continuous PN for ≥ 6 months, and had SBS or undergone SBS-related surgery with a diagnosis of a causative disease. The primary endpoint was PN weaning.ResultsWe analyzed data for 393 patients. The most frequent causes of SBS-IF were ileus (31.8%), Crohn’s disease (20.1%), and mesenteric ischemia (16.0%). Of 144/393 (36.6%) patients who were weaned off their PN, 48 (33.3%) were subsequently restarted on PN. Of 276/393 (70.2%) patients whose PN was initiated in hospital, 156 (56.5%) transitioned to home management. The mean duration of initial PN was 450.4 and 675.5 days for patients who were able or unable to be weaned off PN, respectively. Sepsis (67.4%), catheter-related bloodstream infections (49.1%), and liver disorders (45.0%) were the most reported PN-related complications.ConclusionsMost patients with SBS-IF in Japan could not be weaned off PN and suffered life-threatening complications. More... »

PAGES

1350-1357

References to SciGraph publications

  • 2013-11-20. Das Kurzdarmsyndrom in Deutschland in DIE CHIRURGIE
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    URI

    http://scigraph.springernature.com/pub.10.1007/s00595-022-02469-9

    DOI

    http://dx.doi.org/10.1007/s00595-022-02469-9

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35195767


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