A Japanese multicenter phase II study of adjuvant chemotherapy with mFOLFOX6/CAPOX for stage III colon cancer treatment after D2/D3 lymphadenectomy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-05

AUTHORS

Kazuhiko Yoshimatsu, Keiichiro Ishibashi, Keiji Koda, Hajime Yokomizo, Noritaka Oda, Mitsuru Oshiro, Hiroyuki Kato, Masatoshi Oya, Hideo Nakajima, Shinji Ooki, Hiroshi Maekawa, Toshio Matsunami, Masahiro Tsubaki, Takeshi Yamada, Michiya Kobayashi, Kohji Tanakaya, Masaru Yokoyama, Hideyuki Ishida

ABSTRACT

PurposeA phase II trial was conducted to investigate the benefit of oxaliplatin-based adjuvant chemotherapy in Japanese stage III colon cancer patients.MethodsEligible patients were scheduled to receive 12 cycles of mFOLFOX6 or 8 cycles of CAPOX in adjuvant settings. The primary endpoint was the 3-year disease-free survival (DFS). Cox proportional hazards regression was performed to identify risk factors for a worse DFS.ResultsA total of 130 patients, including 73 patients receiving mFOLFOX6 and 57 patients receiving CAPOX, were enrolled from 16 institutions between April 2010 and April 2014. The 3-year DFS was 82.2%, exceeding the expected primary endpoint of 81.7%. The 3-year DFS tended to be higher in patients receiving mFOLOFOX6 than in those receiving CAPOX (mFOLFOX6, 86.3%; CAPOX, 76.9%; P = 0.06). The 3-year DFS rates did not differ markedly based on the risk stratification (T1/T2/T3 N1 vs. T4 or N2) indicated by the IDEA COLLABORATION study (P = 0.22). In the multivariate analysis, stage IIIC (P = 0.046) and early discontinuation (P < 0.01) were identified as independent significant risk factors for a worse DFS.ConclusionOur findings represent the first positive results in a Japanese phase II trial of adjuvant chemotherapy with mFOLFOX6/CAPOX. Early discontinuation within 2 months was an independent risk factor for a shorter DFS. More... »

PAGES

498-506

Journal

TITLE

Surgery Today

ISSUE

6

VOLUME

49

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00595-019-1771-y

DOI

http://dx.doi.org/10.1007/s00595-019-1771-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113261758

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30953164


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