Recombinant human soluble thrombomodulin reduces the severity and incidence of necrotizing enterocolitis in a newborn rat model View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-06-12

AUTHORS

Bo Li, Ryuta Saka, Yuichi Takama, Takehisa Ueno, Yuko Tazuke, Hiroomi Okuyama

ABSTRACT

PurposeNecrotizing enterocolitis (NEC) remains the leading cause of death in preterm infants. Recombinant human soluble thrombomodulin (rTM) has been reported to have anti-inflammatory effects as well as antithrombogenic effects. The aim of this study was to evaluate the effect of rTM in a rat NEC model.MethodsNEC was induced by enteral feeding with hyperosmolar formula, gavage administration of lipopolysaccharide and asphyxia stress. Controls were fed by their mother ad libitum. In the treatment group, rTM was administered subcutaneously twice (once each on the first and second day). All animals surviving beyond 96 h or that developed signs of distress were euthanized. The ileum was harvested for a histological evaluation and the measurement of the mRNA and protein expression.ResultsThe rate of NEC-like intestinal injury in the treatment group (9/25, 36%) was significantly lower than in the NEC group (25/34, 73.5%). Tissue levels of TNF-α, IL-6 and HMGB1 were significantly elevated in the NEC group, whereas those in the treatment group were decreased to similar values as in the control group.ConclusionsOur experimental study showed that rTM is able to reduce the severity and incidence of NEC. It may be an alternative option for the treatment of NEC. More... »

PAGES

971-976

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00595-019-01832-7

DOI

http://dx.doi.org/10.1007/s00595-019-01832-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1117065451

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31190184


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