Conversion surgery for initially unresectable pancreatic cancer: current status and unresolved issues View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04-04

AUTHORS

Hideyuki Yoshitomi, Shigetsugu Takano, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Masayuki Ohtsuka

ABSTRACT

Pancreatic cancer is one of the most lethal of all malignancies. One of the reasons for the dismal prognosis is that most diagnoses are made when the disease is either locally advanced or metastatic. Recent advances in chemotherapy and chemoradiotherapy (CRT) enable “conversion surgery” to be performed for selected patients with initially unresectable pancreatic cancer following favorable responses to preoperative treatment. Using FOLFIRINOX as preoperative treatment, the resection rate was reported as 6–44% of patients with locally advanced cancer and the prognosis of these patients was favorable. Even for metastasized cancer, recent reports show the effectiveness of conversion surgery, which has achieved 27–56 months of median overall survival. However, there are many unanswered questions about conversion surgery. The optimal regimen and duration of preoperative treatment remain unclear and there is still debate regarding the safety and effectiveness of vascular resection, which is often required for curative resection of locally advanced cancer. Accumulation of more data on conversion surgery is required to establish the safety and effectiveness of this treatment. In this review, we summarize the current status and unresolved issues about conversion surgery for initially unresectable pancreatic cancer. More... »

PAGES

894-906

References to SciGraph publications

  • 2017-01-06. Efficacy and Safety of FOLFIRINOX in Locally Advanced Pancreatic Cancer. A Single Center Experience. in PATHOLOGY & ONCOLOGY RESEARCH
  • 2009-12-05. A phase II study of induction chemotherapy with gemcitabine plus S-1 followed by chemoradiotherapy for locally advanced pancreatic cancer in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2007-03-03. An Innovative Option for Venous Reconstruction After Pancreaticoduodenectomy: the Left Renal Vein in JOURNAL OF GASTROINTESTINAL SURGERY
  • 2016-04-25. CA19-9 Normalization During Pre-operative Treatment Predicts Longer Survival for Patients with Locally Progressed Pancreatic Cancer in JOURNAL OF GASTROINTESTINAL SURGERY
  • 2018-05-14. FOLFIRINOX Versus Gemcitabine/Nab-Paclitaxel for Neoadjuvant Treatment of Resectable and Borderline Resectable Pancreatic Head Adenocarcinoma in ANNALS OF SURGICAL ONCOLOGY
  • 2016-01-29. An Untapped Resource: Left Renal Vein Interposition Graft for Portal Vein Reconstruction During Pancreaticoduodenectomy in DIGESTIVE DISEASES AND SCIENCES
  • 2018-04-20. Surgery after FOLFIRINOX treatment for locally advanced and borderline resectable pancreatic cancer: increase in tumour attenuation on CT correlates with R0 resection in EUROPEAN RADIOLOGY
  • 2017-10-10. Neoadjuvant treatment of pancreatic adenocarcinoma: a systematic review and meta-analysis of 5520 patients in WORLD JOURNAL OF SURGICAL ONCOLOGY
  • 2006-05-10. Indications and Techniques of Extended Resection for Pancreatic Cancer in WORLD JOURNAL OF SURGERY
  • 2016-07-30. Locally advanced pancreatic duct adenocarcinoma: pancreatectomy with planned arterial resection based on axial arterial encasement in LANGENBECK'S ARCHIVES OF SURGERY
  • 2016-08-05. Distal Pancreatectomy with en Bloc Celiac Axis Resection (Modified Appleby Procedure) for Locally Advanced Pancreatic Body Cancer: A Single-Center Review of 80 Consecutive Patients in ANNALS OF SURGICAL ONCOLOGY
  • 2012-03-08. Distal Pancreatectomy with En Bloc Celiac Axis Resection for Locally Advanced Pancreatic Adenocarcinoma Following Neoadjuvant Therapy in JOURNAL OF GASTROINTESTINAL SURGERY
  • 2014-07-19. FOLFIRINOX for Locally Advanced Pancreatic Adenocarcinoma: Results of an AGEO Multicenter Prospective Observational Cohort in ANNALS OF SURGICAL ONCOLOGY
  • 2017-05-17. Downstaging in Stage IV Pancreatic Cancer: A New Population Eligible for Surgery? in ANNALS OF SURGICAL ONCOLOGY
  • 2016-11-15. Plastic vs. Self-Expandable Metal Stents for Palliation in Malignant Biliary Obstruction: A Series of Meta-Analyses in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2017-12-29. A long-term survival case treated with conversion surgery following chemotherapy after diagnostic metastasectomy for pancreatic cancer with synchronous liver metastasis in SURGICAL CASE REPORTS
  • 2016-11-28. CT evaluation after neoadjuvant FOLFIRINOX chemotherapy for borderline and locally advanced pancreatic adenocarcinoma in EUROPEAN RADIOLOGY
  • 2012-05-29. A retrospective study of neoadjuvant FOLFIRINOX in unresectable or borderline-resectable locally advanced pancreatic adenocarcinoma in BMC CANCER
  • 2016-02-03. Phase I/II study of nab-paclitaxel plus gemcitabine for chemotherapy-naive Japanese patients with metastatic pancreatic cancer in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2006-10-25. Pancreatic Resection for M1 Pancreatic Ductal Adenocarcinoma in ANNALS OF SURGICAL ONCOLOGY
  • 2016-07-01. Systematic Review of Resection Rates and Clinical Outcomes After FOLFIRINOX-Based Treatment in Patients with Locally Advanced Pancreatic Cancer in ANNALS OF SURGICAL ONCOLOGY
  • 2015-09-08. Resectability After First-Line FOLFIRINOX in Initially Unresectable Locally Advanced Pancreatic Cancer: A Single-Center Experience in ANNALS OF SURGICAL ONCOLOGY
  • 2016-09. Pancreatic cancer and liver metastases: state of the art in UPDATES IN SURGERY
  • 2018-10-19. Optimizing the outcomes of pancreatic cancer surgery in NATURE REVIEWS CLINICAL ONCOLOGY
  • 2017-03-30. Combined hepatic arterial resection in pancreatic resections for locally advanced pancreatic cancer in LANGENBECK'S ARCHIVES OF SURGERY
  • 2014-10-31. Neoadjuvant Modified (m) FOLFIRINOX for Locally Advanced Unresectable (LAPC) and Borderline Resectable (BRPC) Adenocarcinoma of the Pancreas in ANNALS OF SURGICAL ONCOLOGY
  • 2011-12-01. The GOFURTGO Study: AGITG Phase II Study of fixed dose rate gemcitabine–oxaliplatin integrated with concomitant 5FU and 3-D conformal radiotherapy for the treatment of localised pancreatic cancer in BRITISH JOURNAL OF CANCER
  • 2016-09-07. Primary Tumor Resection Following Favorable Response to Systemic Chemotherapy in Stage IV Pancreatic Adenocarcinoma with Synchronous Metastases: a Bi-institutional Analysis in JOURNAL OF GASTROINTESTINAL SURGERY
  • 2011-12-01. Downstaging in Pancreatic Cancer: A Matched Analysis of Patients Resected Following Systemic Treatment of Initially Locally Unresectable Disease in ANNALS OF SURGICAL ONCOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00595-019-01804-x

    DOI

    http://dx.doi.org/10.1007/s00595-019-01804-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113185258

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30949842


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Combined Chemotherapy Protocols", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chemoradiotherapy, Adjuvant", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chemotherapy, Adjuvant", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Combined Modality Therapy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fluorouracil", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Irinotecan", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Leucovorin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Oxaliplatin", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pancreatectomy", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Pancreatic Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Preoperative Care", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prognosis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Survival Rate", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of General Surgery, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan", 
              "id": "http://www.grid.ac/institutes/grid.136304.3", 
              "name": [
                "Department of General Surgery, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yoshitomi", 
            "givenName": "Hideyuki", 
            "id": "sg:person.01245062664.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245062664.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of General Surgery, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan", 
              "id": "http://www.grid.ac/institutes/grid.136304.3", 
              "name": [
                "Department of General Surgery, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takano", 
            "givenName": "Shigetsugu", 
            "id": "sg:person.01266546053.57", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266546053.57"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of General Surgery, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan", 
              "id": "http://www.grid.ac/institutes/grid.136304.3", 
              "name": [
                "Department of General Surgery, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Furukawa", 
            "givenName": "Katsunori", 
            "id": "sg:person.01013120705.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013120705.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of General Surgery, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan", 
              "id": "http://www.grid.ac/institutes/grid.136304.3", 
              "name": [
                "Department of General Surgery, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takayashiki", 
            "givenName": "Tsukasa", 
            "id": "sg:person.01344552466.53", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344552466.53"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of General Surgery, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan", 
              "id": "http://www.grid.ac/institutes/grid.136304.3", 
              "name": [
                "Department of General Surgery, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kuboki", 
            "givenName": "Satoshi", 
            "id": "sg:person.0621146366.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621146366.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of General Surgery, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan", 
              "id": "http://www.grid.ac/institutes/grid.136304.3", 
              "name": [
                "Department of General Surgery, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ohtsuka", 
            "givenName": "Masayuki", 
            "id": "sg:person.0653527253.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653527253.30"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/bjc.2011.526", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030470332", 
              "https://doi.org/10.1038/bjc.2011.526"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00423-017-1578-5", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084021852", 
              "https://doi.org/10.1007/s00423-017-1578-5"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41571-018-0112-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107711443", 
              "https://doi.org/10.1038/s41571-018-0112-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s13304-016-0407-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013978101", 
              "https://doi.org/10.1007/s13304-016-0407-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-017-5885-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085431222", 
              "https://doi.org/10.1245/s10434-017-5885-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-014-3898-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1030376143", 
              "https://doi.org/10.1245/s10434-014-3898-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s12957-017-1240-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1092156162", 
              "https://doi.org/10.1186/s12957-017-1240-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11605-012-1839-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011292551", 
              "https://doi.org/10.1007/s11605-012-1839-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-016-5373-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002694773", 
              "https://doi.org/10.1245/s10434-016-5373-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11605-007-0131-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039770143", 
              "https://doi.org/10.1007/s11605-007-0131-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-014-4225-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028014895", 
              "https://doi.org/10.1245/s10434-014-4225-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s12253-016-0176-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050606254", 
              "https://doi.org/10.1007/s12253-016-0176-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00268-005-0438-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029015570", 
              "https://doi.org/10.1007/s00268-005-0438-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-12-199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046942754", 
              "https://doi.org/10.1186/1471-2407-12-199"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00330-016-4632-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051767111", 
              "https://doi.org/10.1007/s00330-016-4632-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s40792-017-0409-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100100074", 
              "https://doi.org/10.1186/s40792-017-0409-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-011-2156-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010612375", 
              "https://doi.org/10.1245/s10434-011-2156-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2016.512", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051205640", 
              "https://doi.org/10.1038/ajg.2016.512"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-016-2972-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031624786", 
              "https://doi.org/10.1007/s00280-016-2972-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-018-6512-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103978685", 
              "https://doi.org/10.1245/s10434-018-6512-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11605-016-3256-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026355647", 
              "https://doi.org/10.1007/s11605-016-3256-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10620-016-4050-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006573358", 
              "https://doi.org/10.1007/s10620-016-4050-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00330-018-5410-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1103486827", 
              "https://doi.org/10.1007/s00330-018-5410-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00423-016-1488-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026131696", 
              "https://doi.org/10.1007/s00423-016-1488-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-006-9131-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040443585", 
              "https://doi.org/10.1245/s10434-006-9131-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-016-5493-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052184532", 
              "https://doi.org/10.1245/s10434-016-5493-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-009-1193-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038220872", 
              "https://doi.org/10.1007/s00280-009-1193-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11605-016-3149-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038673038", 
              "https://doi.org/10.1007/s11605-016-3149-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1245/s10434-015-4851-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001949081", 
              "https://doi.org/10.1245/s10434-015-4851-2"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2019-04-04", 
        "datePublishedReg": "2019-04-04", 
        "description": "Pancreatic cancer is one of the most lethal of all malignancies. One of the reasons for the dismal prognosis is that most diagnoses are made when the disease is either locally advanced or metastatic. Recent advances in chemotherapy and chemoradiotherapy (CRT) enable \u201cconversion surgery\u201d to be performed for selected patients with initially unresectable pancreatic cancer following favorable responses to preoperative treatment. Using FOLFIRINOX as preoperative treatment, the resection rate was reported as 6\u201344% of patients with locally advanced cancer and the prognosis of these patients was favorable. Even for metastasized cancer, recent reports show the effectiveness of conversion surgery, which has achieved 27\u201356\u00a0months of median overall survival. However, there are many unanswered questions about conversion surgery. The optimal regimen and duration of preoperative treatment remain unclear and there is still debate regarding the safety and effectiveness of vascular resection, which is often required for curative resection of locally advanced cancer. Accumulation of more data on conversion surgery is required to establish the safety and effectiveness of this treatment. In this review, we summarize the current status and unresolved issues about conversion surgery for initially unresectable pancreatic cancer.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00595-019-01804-x", 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.8428785", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.7535501", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1102161", 
            "issn": [
              "0941-1291", 
              "1436-2813"
            ], 
            "name": "Surgery Today", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "11", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "49"
          }
        ], 
        "keywords": [
          "unresectable pancreatic cancer", 
          "conversion surgery", 
          "pancreatic cancer", 
          "preoperative treatment", 
          "advanced cancer", 
          "median overall survival", 
          "curative resection", 
          "resection rate", 
          "vascular resection", 
          "overall survival", 
          "optimal regimen", 
          "dismal prognosis", 
          "most diagnoses", 
          "surgery", 
          "favorable response", 
          "cancer", 
          "patients", 
          "chemoradiotherapy", 
          "resection", 
          "prognosis", 
          "treatment", 
          "recent reports", 
          "current status", 
          "unresolved issues", 
          "unanswered questions", 
          "status", 
          "safety", 
          "FOLFIRINOX", 
          "regimen", 
          "chemotherapy", 
          "malignancy", 
          "disease", 
          "diagnosis", 
          "months", 
          "more data", 
          "survival", 
          "recent advances", 
          "duration", 
          "report", 
          "review", 
          "response", 
          "effectiveness", 
          "accumulation", 
          "rate", 
          "advances", 
          "data", 
          "reasons", 
          "issues", 
          "questions", 
          "debate"
        ], 
        "name": "Conversion surgery for initially unresectable pancreatic cancer: current status and unresolved issues", 
        "pagination": "894-906", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1113185258"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00595-019-01804-x"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "30949842"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00595-019-01804-x", 
          "https://app.dimensions.ai/details/publication/pub.1113185258"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-11-24T21:02", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20221124/entities/gbq_results/article/article_793.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00595-019-01804-x"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00595-019-01804-x'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00595-019-01804-x'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00595-019-01804-x'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00595-019-01804-x'


     

    This table displays all metadata directly associated to this object as RDF triples.

    330 TRIPLES      21 PREDICATES      120 URIs      83 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00595-019-01804-x schema:about N0833b17f8e154197adbf21614f2b6526
    2 N23107903af944cf0bc15b1d36720c157
    3 N2f9d03b1e6464fd7bb94902c22042a2f
    4 N2fdcc43db0b248c6884cb96f31b3479c
    5 N3cc2b91eea5a45db845cdd759b531474
    6 N50e5d3f820814ea194137f0f8a36e0e9
    7 N58ead604a7494f0096f71b51122334c0
    8 N7a8b777f3c4b4579981b03b1387cdc31
    9 N8f21eff55f6f4c6592232cd183a92334
    10 Na020a6befb0a46659d6ffb3e13e05e81
    11 Na1fa63acd84d4798af64c59e76064374
    12 Na3120f5868f74f3589fc499ad0ef885e
    13 Nb08f1c3b8fcf4cbbaa0cc8a0deac13b6
    14 Nc0c36b2d0f76439f97a0959e29c63e72
    15 Ne5e16a1a6c634daeb675171d28640b79
    16 Nf047942d62d34001afc9ac4b5547de38
    17 anzsrc-for:11
    18 anzsrc-for:1112
    19 schema:author N9c85ed3184e04113bb1e326c36b42663
    20 schema:citation sg:pub.10.1007/s00268-005-0438-6
    21 sg:pub.10.1007/s00280-009-1193-4
    22 sg:pub.10.1007/s00280-016-2972-3
    23 sg:pub.10.1007/s00330-016-4632-8
    24 sg:pub.10.1007/s00330-018-5410-6
    25 sg:pub.10.1007/s00423-016-1488-y
    26 sg:pub.10.1007/s00423-017-1578-5
    27 sg:pub.10.1007/s10620-016-4050-4
    28 sg:pub.10.1007/s11605-007-0131-1
    29 sg:pub.10.1007/s11605-012-1839-0
    30 sg:pub.10.1007/s11605-016-3149-4
    31 sg:pub.10.1007/s11605-016-3256-2
    32 sg:pub.10.1007/s12253-016-0176-0
    33 sg:pub.10.1007/s13304-016-0407-7
    34 sg:pub.10.1038/ajg.2016.512
    35 sg:pub.10.1038/bjc.2011.526
    36 sg:pub.10.1038/s41571-018-0112-1
    37 sg:pub.10.1186/1471-2407-12-199
    38 sg:pub.10.1186/s12957-017-1240-2
    39 sg:pub.10.1186/s40792-017-0409-9
    40 sg:pub.10.1245/s10434-006-9131-8
    41 sg:pub.10.1245/s10434-011-2156-7
    42 sg:pub.10.1245/s10434-014-3898-9
    43 sg:pub.10.1245/s10434-014-4225-1
    44 sg:pub.10.1245/s10434-015-4851-2
    45 sg:pub.10.1245/s10434-016-5373-2
    46 sg:pub.10.1245/s10434-016-5493-8
    47 sg:pub.10.1245/s10434-017-5885-4
    48 sg:pub.10.1245/s10434-018-6512-8
    49 schema:datePublished 2019-04-04
    50 schema:datePublishedReg 2019-04-04
    51 schema:description Pancreatic cancer is one of the most lethal of all malignancies. One of the reasons for the dismal prognosis is that most diagnoses are made when the disease is either locally advanced or metastatic. Recent advances in chemotherapy and chemoradiotherapy (CRT) enable “conversion surgery” to be performed for selected patients with initially unresectable pancreatic cancer following favorable responses to preoperative treatment. Using FOLFIRINOX as preoperative treatment, the resection rate was reported as 6–44% of patients with locally advanced cancer and the prognosis of these patients was favorable. Even for metastasized cancer, recent reports show the effectiveness of conversion surgery, which has achieved 27–56 months of median overall survival. However, there are many unanswered questions about conversion surgery. The optimal regimen and duration of preoperative treatment remain unclear and there is still debate regarding the safety and effectiveness of vascular resection, which is often required for curative resection of locally advanced cancer. Accumulation of more data on conversion surgery is required to establish the safety and effectiveness of this treatment. In this review, we summarize the current status and unresolved issues about conversion surgery for initially unresectable pancreatic cancer.
    52 schema:genre article
    53 schema:isAccessibleForFree false
    54 schema:isPartOf Naa479d5fa484446f9d37cf96bca43d89
    55 Neca931e4aee74322a07dacb870b495fc
    56 sg:journal.1102161
    57 schema:keywords FOLFIRINOX
    58 accumulation
    59 advanced cancer
    60 advances
    61 cancer
    62 chemoradiotherapy
    63 chemotherapy
    64 conversion surgery
    65 curative resection
    66 current status
    67 data
    68 debate
    69 diagnosis
    70 disease
    71 dismal prognosis
    72 duration
    73 effectiveness
    74 favorable response
    75 issues
    76 malignancy
    77 median overall survival
    78 months
    79 more data
    80 most diagnoses
    81 optimal regimen
    82 overall survival
    83 pancreatic cancer
    84 patients
    85 preoperative treatment
    86 prognosis
    87 questions
    88 rate
    89 reasons
    90 recent advances
    91 recent reports
    92 regimen
    93 report
    94 resection
    95 resection rate
    96 response
    97 review
    98 safety
    99 status
    100 surgery
    101 survival
    102 treatment
    103 unanswered questions
    104 unresectable pancreatic cancer
    105 unresolved issues
    106 vascular resection
    107 schema:name Conversion surgery for initially unresectable pancreatic cancer: current status and unresolved issues
    108 schema:pagination 894-906
    109 schema:productId N38774f81a91246ed9e3289600db363a5
    110 N419132a42b33408381698d85f088fbf4
    111 N49e50c0c92a6424c982ea50c30d653bb
    112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113185258
    113 https://doi.org/10.1007/s00595-019-01804-x
    114 schema:sdDatePublished 2022-11-24T21:02
    115 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    116 schema:sdPublisher N73134d0b12eb4bfb855e8483f9c9c7a6
    117 schema:url https://doi.org/10.1007/s00595-019-01804-x
    118 sgo:license sg:explorer/license/
    119 sgo:sdDataset articles
    120 rdf:type schema:ScholarlyArticle
    121 N0833b17f8e154197adbf21614f2b6526 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Female
    123 rdf:type schema:DefinedTerm
    124 N23107903af944cf0bc15b1d36720c157 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    125 schema:name Antineoplastic Combined Chemotherapy Protocols
    126 rdf:type schema:DefinedTerm
    127 N2f9d03b1e6464fd7bb94902c22042a2f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    128 schema:name Combined Modality Therapy
    129 rdf:type schema:DefinedTerm
    130 N2fdcc43db0b248c6884cb96f31b3479c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    131 schema:name Preoperative Care
    132 rdf:type schema:DefinedTerm
    133 N377fd0d8550f46df9c870deacbbf0ade rdf:first sg:person.01013120705.66
    134 rdf:rest N9d42eceb03584421b0c11b32750946ff
    135 N38774f81a91246ed9e3289600db363a5 schema:name dimensions_id
    136 schema:value pub.1113185258
    137 rdf:type schema:PropertyValue
    138 N3cc2b91eea5a45db845cdd759b531474 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    139 schema:name Pancreatectomy
    140 rdf:type schema:DefinedTerm
    141 N419132a42b33408381698d85f088fbf4 schema:name pubmed_id
    142 schema:value 30949842
    143 rdf:type schema:PropertyValue
    144 N49e50c0c92a6424c982ea50c30d653bb schema:name doi
    145 schema:value 10.1007/s00595-019-01804-x
    146 rdf:type schema:PropertyValue
    147 N50e5d3f820814ea194137f0f8a36e0e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    148 schema:name Prognosis
    149 rdf:type schema:DefinedTerm
    150 N58ead604a7494f0096f71b51122334c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    151 schema:name Pancreatic Neoplasms
    152 rdf:type schema:DefinedTerm
    153 N5b06f34fb4d243c79142e7ac9967e837 rdf:first sg:person.0621146366.76
    154 rdf:rest N7af67c4939b34e55901dd76e2294156c
    155 N5c6ec1bf727e4eb998eb1441763f6ca8 rdf:first sg:person.01266546053.57
    156 rdf:rest N377fd0d8550f46df9c870deacbbf0ade
    157 N73134d0b12eb4bfb855e8483f9c9c7a6 schema:name Springer Nature - SN SciGraph project
    158 rdf:type schema:Organization
    159 N7a8b777f3c4b4579981b03b1387cdc31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Chemoradiotherapy, Adjuvant
    161 rdf:type schema:DefinedTerm
    162 N7af67c4939b34e55901dd76e2294156c rdf:first sg:person.0653527253.30
    163 rdf:rest rdf:nil
    164 N8f21eff55f6f4c6592232cd183a92334 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Chemotherapy, Adjuvant
    166 rdf:type schema:DefinedTerm
    167 N9c85ed3184e04113bb1e326c36b42663 rdf:first sg:person.01245062664.63
    168 rdf:rest N5c6ec1bf727e4eb998eb1441763f6ca8
    169 N9d42eceb03584421b0c11b32750946ff rdf:first sg:person.01344552466.53
    170 rdf:rest N5b06f34fb4d243c79142e7ac9967e837
    171 Na020a6befb0a46659d6ffb3e13e05e81 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    172 schema:name Humans
    173 rdf:type schema:DefinedTerm
    174 Na1fa63acd84d4798af64c59e76064374 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    175 schema:name Male
    176 rdf:type schema:DefinedTerm
    177 Na3120f5868f74f3589fc499ad0ef885e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    178 schema:name Oxaliplatin
    179 rdf:type schema:DefinedTerm
    180 Naa479d5fa484446f9d37cf96bca43d89 schema:volumeNumber 49
    181 rdf:type schema:PublicationVolume
    182 Nb08f1c3b8fcf4cbbaa0cc8a0deac13b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    183 schema:name Leucovorin
    184 rdf:type schema:DefinedTerm
    185 Nc0c36b2d0f76439f97a0959e29c63e72 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Survival Rate
    187 rdf:type schema:DefinedTerm
    188 Ne5e16a1a6c634daeb675171d28640b79 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    189 schema:name Irinotecan
    190 rdf:type schema:DefinedTerm
    191 Neca931e4aee74322a07dacb870b495fc schema:issueNumber 11
    192 rdf:type schema:PublicationIssue
    193 Nf047942d62d34001afc9ac4b5547de38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    194 schema:name Fluorouracil
    195 rdf:type schema:DefinedTerm
    196 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    197 schema:name Medical and Health Sciences
    198 rdf:type schema:DefinedTerm
    199 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    200 schema:name Oncology and Carcinogenesis
    201 rdf:type schema:DefinedTerm
    202 sg:grant.7535501 http://pending.schema.org/fundedItem sg:pub.10.1007/s00595-019-01804-x
    203 rdf:type schema:MonetaryGrant
    204 sg:grant.8428785 http://pending.schema.org/fundedItem sg:pub.10.1007/s00595-019-01804-x
    205 rdf:type schema:MonetaryGrant
    206 sg:journal.1102161 schema:issn 0941-1291
    207 1436-2813
    208 schema:name Surgery Today
    209 schema:publisher Springer Nature
    210 rdf:type schema:Periodical
    211 sg:person.01013120705.66 schema:affiliation grid-institutes:grid.136304.3
    212 schema:familyName Furukawa
    213 schema:givenName Katsunori
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013120705.66
    215 rdf:type schema:Person
    216 sg:person.01245062664.63 schema:affiliation grid-institutes:grid.136304.3
    217 schema:familyName Yoshitomi
    218 schema:givenName Hideyuki
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01245062664.63
    220 rdf:type schema:Person
    221 sg:person.01266546053.57 schema:affiliation grid-institutes:grid.136304.3
    222 schema:familyName Takano
    223 schema:givenName Shigetsugu
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01266546053.57
    225 rdf:type schema:Person
    226 sg:person.01344552466.53 schema:affiliation grid-institutes:grid.136304.3
    227 schema:familyName Takayashiki
    228 schema:givenName Tsukasa
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344552466.53
    230 rdf:type schema:Person
    231 sg:person.0621146366.76 schema:affiliation grid-institutes:grid.136304.3
    232 schema:familyName Kuboki
    233 schema:givenName Satoshi
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621146366.76
    235 rdf:type schema:Person
    236 sg:person.0653527253.30 schema:affiliation grid-institutes:grid.136304.3
    237 schema:familyName Ohtsuka
    238 schema:givenName Masayuki
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653527253.30
    240 rdf:type schema:Person
    241 sg:pub.10.1007/s00268-005-0438-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029015570
    242 https://doi.org/10.1007/s00268-005-0438-6
    243 rdf:type schema:CreativeWork
    244 sg:pub.10.1007/s00280-009-1193-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038220872
    245 https://doi.org/10.1007/s00280-009-1193-4
    246 rdf:type schema:CreativeWork
    247 sg:pub.10.1007/s00280-016-2972-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031624786
    248 https://doi.org/10.1007/s00280-016-2972-3
    249 rdf:type schema:CreativeWork
    250 sg:pub.10.1007/s00330-016-4632-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051767111
    251 https://doi.org/10.1007/s00330-016-4632-8
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1007/s00330-018-5410-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103486827
    254 https://doi.org/10.1007/s00330-018-5410-6
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1007/s00423-016-1488-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1026131696
    257 https://doi.org/10.1007/s00423-016-1488-y
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1007/s00423-017-1578-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084021852
    260 https://doi.org/10.1007/s00423-017-1578-5
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1007/s10620-016-4050-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006573358
    263 https://doi.org/10.1007/s10620-016-4050-4
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1007/s11605-007-0131-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039770143
    266 https://doi.org/10.1007/s11605-007-0131-1
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1007/s11605-012-1839-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011292551
    269 https://doi.org/10.1007/s11605-012-1839-0
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1007/s11605-016-3149-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038673038
    272 https://doi.org/10.1007/s11605-016-3149-4
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1007/s11605-016-3256-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026355647
    275 https://doi.org/10.1007/s11605-016-3256-2
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1007/s12253-016-0176-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050606254
    278 https://doi.org/10.1007/s12253-016-0176-0
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1007/s13304-016-0407-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013978101
    281 https://doi.org/10.1007/s13304-016-0407-7
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1038/ajg.2016.512 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051205640
    284 https://doi.org/10.1038/ajg.2016.512
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1038/bjc.2011.526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030470332
    287 https://doi.org/10.1038/bjc.2011.526
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1038/s41571-018-0112-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1107711443
    290 https://doi.org/10.1038/s41571-018-0112-1
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1186/1471-2407-12-199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046942754
    293 https://doi.org/10.1186/1471-2407-12-199
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1186/s12957-017-1240-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092156162
    296 https://doi.org/10.1186/s12957-017-1240-2
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1186/s40792-017-0409-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100100074
    299 https://doi.org/10.1186/s40792-017-0409-9
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1245/s10434-006-9131-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040443585
    302 https://doi.org/10.1245/s10434-006-9131-8
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1245/s10434-011-2156-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010612375
    305 https://doi.org/10.1245/s10434-011-2156-7
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1245/s10434-014-3898-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030376143
    308 https://doi.org/10.1245/s10434-014-3898-9
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1245/s10434-014-4225-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028014895
    311 https://doi.org/10.1245/s10434-014-4225-1
    312 rdf:type schema:CreativeWork
    313 sg:pub.10.1245/s10434-015-4851-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001949081
    314 https://doi.org/10.1245/s10434-015-4851-2
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1245/s10434-016-5373-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002694773
    317 https://doi.org/10.1245/s10434-016-5373-2
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1245/s10434-016-5493-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052184532
    320 https://doi.org/10.1245/s10434-016-5493-8
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1245/s10434-017-5885-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085431222
    323 https://doi.org/10.1245/s10434-017-5885-4
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1245/s10434-018-6512-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103978685
    326 https://doi.org/10.1245/s10434-018-6512-8
    327 rdf:type schema:CreativeWork
    328 grid-institutes:grid.136304.3 schema:alternateName Department of General Surgery, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan
    329 schema:name Department of General Surgery, Chiba University, Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, 260-8670, Chiba, Japan
    330 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...