Postoperative therapy with infliximab for Crohn’s disease: a 2-year prospective randomized multicenter study in Japan View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-01-30

AUTHORS

Kouhei Fukushima, Akira Sugita, Kitaro Futami, Ken-Ichi Takahashi, Satoshi Motoya, Hideaki Kimura, Shusaku Yoshikawa, Yoshitaka Kinouchi, Hideki Iijima, Katsuya Endo, Toshihumi Hibi, Mamoru Watanabe, Iwao Sasaki, Yasuo Suzuki, Surgical Research Group, the Research Committee of Inflammatory Bowel Disease, the Ministry of Health, Welfare and Labor of Japan

ABSTRACT

PurposeThe prevention of postoperative recurrence is a critical issue in surgery for Crohn’s disease. Prospective randomized trials in Western countries have shown that the postoperative use of anti-tumor necrosis factor α-antibodies was effective in reducing the recurrence rate. We investigated the efficacy of infliximab (IFX) for the prevention of postoperative Crohn’s disease recurrence.MethodsWe performed a prospective randomized multicenter study. Patients who underwent intestinal resection were assigned to groups treated with or without IFX. Immediately after surgery, patients in the IFX group received IFX at 5 mg/kg at 0, 2, and 6 weeks, followed by every 8 weeks for 2 years. The primary study outcome was the proportion of patients with endoscopic and/or clinical recurrence at 2 years after surgery.ResultsThirty-eight eligible patients participated in this study: 19 in the IFX group and 19 in the non-IFX group. The disease recurrence rate in the IFX group was 52.6% (10/19), which was significantly lower than that in the non-IFX group (94.7% [18/19]).ConclusionThe postoperative use of IFX is effective in preventing Crohn’s disease recurrence for 2 years. More... »

PAGES

584-590

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00595-018-1627-x

DOI

http://dx.doi.org/10.1007/s00595-018-1627-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100718490

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29383596


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38 anti-tumor necrosis factor α
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40 clinical recurrence
41 countries
42 critical issue
43 disease
44 disease recurrence
45 disease recurrence rate
46 efficacy
47 efficacy of infliximab
48 eligible patients
49 factor α
50 group
51 infliximab
52 intestinal resection
53 issues
54 multicenter study
55 necrosis factor α
56 outcomes
57 patients
58 postoperative Crohn's disease recurrence
59 postoperative recurrence
60 postoperative therapy
61 postoperative use
62 prevention
63 primary study outcome
64 proportion
65 proportion of patients
66 prospective randomized trials
67 randomized trials
68 rate
69 recurrence
70 recurrence rate
71 resection
72 study
73 study outcomes
74 surgery
75 therapy
76 trials
77 use
78 weeks
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