Serum total bilirubin elevation is a predictor of the clinicopathological severity of acute appendicitis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-07-24

AUTHORS

Satoshi Nomura, Masanori Watanabe, Osamu Komine, Takeshi Shioya, Tetsutaka Toyoda, Hideki Bou, Tetsuo Shibuya, Hideyuki Suzuki, Eiji Uchida

ABSTRACT

PurposeElevation of the serum total bilirubin (STB) level not stemming from hepatic dysfunction or biliary obstruction may be seen in cases of acute appendicitis. This paper deals with the clinical significance of such elevations.MethodsData from 410 appendectomized patients classified into two groups (a high preoperative STB group and a normal preoperative STB group) were analyzed to reveal the significance of preoperative hyperbilirubinemia. We also examined whether the preoperative STB level might serve as a risk factor for gangrenous appendicitis by a multivariate analysis.ResultsGangrenous appendicitis was more common in the high preoperative STB group (p < 0.001). The multivariate analysis revealed that an elevated preoperative STB level (odds ratio 1.7919) was a risk factor for gangrenous appendicitis.ConclusionIn patients with an elevated preoperative STB level, it is very likely that the inflammation is severe and that the disease has progressed to a severe condition histopathologically; therefore, meticulous attention should be paid to the selection of the surgical procedure, as well as to the postoperative clinical course. More... »

PAGES

1104-1108

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00595-013-0659-5

DOI

http://dx.doi.org/10.1007/s00595-013-0659-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003119648

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23880964


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