Ontology type: schema:ScholarlyArticle
2009-09-24
AUTHORSMunenori Nagao, Chikashi Shibata, Yuji Funayama, Kouhei Fukushima, Koh Miura, Hitoshi Ogawa, Tatsuya Ueno, Katsuyoshi Kudoh, Michiaki Unno, Iwao Sasaki
ABSTRACTPurposeThe administration of stimuli to the ileum inhibits upper gastrointestinal motility. The aim of this study was to determine whether a total colectomy can alter this motor inhibitory effect.MethodsBeagle dogs were each equipped with four strain gauge force transducers on the upper gastrointestinal tract. The infusion of nutrients (saline as placebo control, oleate, butyrate, and glucose) began 90 min after feeding and continued for 30 min via a silicone catheter placed in the ileal lumen. Capsaicin (10 mg) was injected into the ileum as a bolus. All of the dogs underwent a relaparotomy and a total colectomy, and the same experiments were performed on all dogs.ResultsBefore performing a colectomy, the oleate, the glucose, and the capsaicin were each found to inhibit the postprandial upper gastrointestinal motility in comparison to the placebo control (P < 0.05). The butyrate had no inhibitory effect. After a total colectomy, the inhibition of upper gastrointestinal motility was observed after the intraileal infusion of the oleate and the capsaicin (P < 0.05). The motor inhibitory response to the intraileal glucose was delayed after a total colectomy, and a reduction of the motility index was not observed in the gastric antrum and the duodenum because of this delay. However, a significant reduction in the motility index was observed in the jejunum.ConclusionThe intraileal stimuli-induced motor inhibition decreased after a total colectomy after the administration of glucose, but not after the administration of either oleate or capsaicin. More... »
PAGES780-786
http://scigraph.springernature.com/pub.10.1007/s00595-009-3953-5
DOIhttp://dx.doi.org/10.1007/s00595-009-3953-5
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1045748221
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/19779774
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