Aggressive undifferentiated colon carcinoma producing granulocyte-colony stimulating factor: Report of a case View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-11-01

AUTHORS

Akihisa Matsuda, Koji Sasajima, Takeshi Matsutani, Hiroshi Maruyama, Masayuki Miyamoto, Tadashi Yokoyama, Seiji Suzuki, Hideyuki Suzuki, Takashi Tajiri

ABSTRACT

We report a rare case of granulocyte-colony stimulating factor (G-CSF)-producing undifferentiated carcinoma of the ascending colon. A 52-year-old Japanese man presented with a rapidly growing, aggressive abdominal tumor, and severe leukocytosis (63 000/mm3). The serum level of G-CSF was remarkably elevated to 640 pg/ml (normal, <18.1 pg/ml). The patient underwent palliative cytoreductive surgery for ascending colon carcinoma with lymph node and liver metastases. Histological examination revealed an undifferentiated carcinoma of the ascending colon. The tumor cells were positive for G-CSF on immunohistochemical staining. The leukocyte counts and G-CSF level decreased after surgery. Thus, we diagnosed G-CSF-producing colon carcinoma. His general condition deteriorated rapidly and he died of residual tumor growth on postoperative day 24. More... »

PAGES

990

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00595-008-3941-1

DOI

http://dx.doi.org/10.1007/s00595-008-3941-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046643829

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19882323


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