Quantitative assessment of therapeutic effects in the critically ischemic limb using 99mTc-diethylene-triamine-pentaacetic acid human serum albumin View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-01

AUTHORS

Jun Kawanishi, Takashi Ohta, Hiroyuki Ishibashi, Ikuo Sugimoto, Hirohide Iwata, Masayuki Takahashi, Tetsuya Yamada, Noriyuki Hida

ABSTRACT

PURPOSE: To investigate the reliability and limitations of a new radioisotope method using (99m)Tc-diethylenetriamine-pentaacetic acid human serum albumin (Tc-99m-DTPA-HSA) and to evaluate the diagnostic ability of isotope infusion for assessing hemodynamic changes in the foot before and after treatment. METHODS: Hemodynamic changes before and after treatment were assessed in 21 limbs with ulcer or gangrene, by analyzing changes in the time-activity curve, the uptake ratio, and the values obtained with noninvasive techniques. RESULTS: There were significant differences between each pair of the three types of time-activity curve and their uptake counts. The uptake ratio was correlated with ankle blood pressure (ABP) and toe blood pressure (TBP), but not with transcutaneous oxygen pressure (tcPO(2)) or skin perfusion pressure (SPP). The hemodynamic change induced by pharmacotherapy was subtle, but that induced by arterial reconstruction was remarkable. Although there was not always a good correlation between the degree of hemodynamic change and the clinical outcome in limbs treated with pharmacotherapy, the hemodynamic change was quantitatively assessed. CONCLUSION: Our study suggests that this isotope technique is a useful quantitative method to evaluate hemodynamic change from a different perspective to conventional noninvasive methods. More... »

PAGES

14-20

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00595-008-3778-7

DOI

http://dx.doi.org/10.1007/s00595-008-3778-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042036231

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19132462


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