Interleukin-8, Cyclo-oxygenase-2, and Trefoil Factor Family 1 Gene Expression and Their Association with Helicobacter pylori Infection in the Remnant Stomach View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2005-12

AUTHORS

Chengzhong Xing, Shunji Kato, Norio Matsukura, Noriko Matsuda, Huimian Xu, En Takashi, Nobutaka Yamada, Zenya Naito, Takashi Tajiri

ABSTRACT

PurposeThe risk factors for secondary stomach carcinogenesis after distal gastrectomy have not been evaluated in detail.MethodsUsing gastrointestinal endoscopy, we examined 112 patients who had undergone gastrectomy. Biopsy specimens were taken from the stoma and the upper corpus mucosa in the remnant stomach to examine the associations among Helicobacter pylori (H.pylori) infection, bile reflux, and the expressions of interleukin-8 (IL-8), cyclo-oxygenase-2 (COX-2), and trefoil factor family 1 (TFF1) genes in the stomach mucosa.ResultsThe IL-8 levels in the corpus mucosa were significantly higher in the H.pylori-positive patients than in the H.pylori-negative patients (P = 0.015). The IL-8 levels were significantly higher in the stomal mucosa than in the corpus mucosa in the H.pylori-positive patients (P = 0.047). The COX-2 levels in the corpus mucosa tended to be higher in the H.pylori-positive patients, but these levels were not significantly different in the stoma mucosa. The COX-2 levels in the corpus were significantly higher after Billroth II (BII) anastomosis than after Billroth I (BI) anastomosis (P = 0.041). TFF1 expression in the stoma was higher in the H.pylori-positive patients than in the H.pylori-negative patients, but the difference was not significant.ConclusionsBoth H.pylori infection and bile reflux increased IL-8 levels after BI anastomosis. Furthermore, COX-2 levels were higher after BII than after BI anastomosis. These indicators will become useful not only as biomarkers to predict the degree of inflammation in the stomach mucosa, but also as surrogate biomarkers to predict the risk of secondary stomach carcinogenesis in the remnant stomach mucosa. More... »

PAGES

1026-1032

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00595-005-3075-7

DOI

http://dx.doi.org/10.1007/s00595-005-3075-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031659818

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16341482


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bile Reflux", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers, Tumor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclooxygenase 2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gastrectomy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gastric Stump", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gastroscopy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Helicobacter Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Helicobacter pylori", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-8", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Predictive Value of Tests", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stomach Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trefoil Factor-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Oncology, First Hospital of China Medical University, Shengyang, China", 
          "id": "http://www.grid.ac/institutes/grid.412636.4", 
          "name": [
            "Department of Surgery for Organ Function and Biological Regulation, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, Japan", 
            "Department of Oncology, First Hospital of China Medical University, Shengyang, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xing", 
        "givenName": "Chengzhong", 
        "id": "sg:person.0603665234.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603665234.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery for Organ Function and Biological Regulation, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410821.e", 
          "name": [
            "Department of Surgery for Organ Function and Biological Regulation, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kato", 
        "givenName": "Shunji", 
        "id": "sg:person.013557374312.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013557374312.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery for Organ Function and Biological Regulation, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410821.e", 
          "name": [
            "Department of Surgery for Organ Function and Biological Regulation, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsukura", 
        "givenName": "Norio", 
        "id": "sg:person.0756125372.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756125372.33"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery for Organ Function and Biological Regulation, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410821.e", 
          "name": [
            "Department of Surgery for Organ Function and Biological Regulation, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsuda", 
        "givenName": "Noriko", 
        "id": "sg:person.01001526627.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001526627.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, First Hospital of China Medical University, Shengyang, China", 
          "id": "http://www.grid.ac/institutes/grid.412636.4", 
          "name": [
            "Department of Oncology, First Hospital of China Medical University, Shengyang, China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Xu", 
        "givenName": "Huimian", 
        "id": "sg:person.01362562045.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362562045.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Integrative Pathology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410821.e", 
          "name": [
            "Department of Integrative Pathology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Takashi", 
        "givenName": "En", 
        "id": "sg:person.0624354200.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624354200.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Integrative Pathology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410821.e", 
          "name": [
            "Department of Integrative Pathology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamada", 
        "givenName": "Nobutaka", 
        "id": "sg:person.010407250562.21", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010407250562.21"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Integrative Pathology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410821.e", 
          "name": [
            "Department of Integrative Pathology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Naito", 
        "givenName": "Zenya", 
        "id": "sg:person.01303445622.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303445622.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Surgery for Organ Function and Biological Regulation, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410821.e", 
          "name": [
            "Department of Surgery for Organ Function and Biological Regulation, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tajiri", 
        "givenName": "Takashi", 
        "id": "sg:person.01357202667.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357202667.08"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s005350050146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010257475", 
          "https://doi.org/10.1007/s005350050146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10120-003-0234-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075315784", 
          "https://doi.org/10.1007/s10120-003-0234-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35094017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002632915", 
          "https://doi.org/10.1038/35094017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/01.lab.0000029205.76632.a8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049326123", 
          "https://doi.org/10.1097/01.lab.0000029205.76632.a8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00535-003-1337-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036045475", 
          "https://doi.org/10.1007/s00535-003-1337-y"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2005-12", 
    "datePublishedReg": "2005-12-01", 
    "description": "PurposeThe risk factors for secondary stomach carcinogenesis after distal gastrectomy have not been evaluated in detail.MethodsUsing gastrointestinal endoscopy, we examined 112 patients who had undergone gastrectomy. Biopsy specimens were taken from the stoma and the upper corpus mucosa in the remnant stomach to examine the associations among Helicobacter pylori (H.pylori) infection, bile reflux, and the expressions of interleukin-8 (IL-8), cyclo-oxygenase-2 (COX-2), and trefoil factor family 1 (TFF1) genes in the stomach mucosa.ResultsThe IL-8 levels in the corpus mucosa were significantly higher in the H.pylori-positive patients than in the H.pylori-negative patients (P = 0.015). The IL-8 levels were significantly higher in the stomal mucosa than in the corpus mucosa in the H.pylori-positive patients (P = 0.047). The COX-2 levels in the corpus mucosa tended to be higher in the H.pylori-positive patients, but these levels were not significantly different in the stoma mucosa. The COX-2 levels in the corpus were significantly higher after Billroth II (BII) anastomosis than after Billroth I (BI) anastomosis (P = 0.041). TFF1 expression in the stoma was higher in the H.pylori-positive patients than in the H.pylori-negative patients, but the difference was not significant.ConclusionsBoth H.pylori infection and bile reflux increased IL-8 levels after BI anastomosis. Furthermore, COX-2 levels were higher after BII than after BI anastomosis. These indicators will become useful not only as biomarkers to predict the degree of inflammation in the stomach mucosa, but also as surrogate biomarkers to predict the risk of secondary stomach carcinogenesis in the remnant stomach mucosa.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00595-005-3075-7", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1102161", 
        "issn": [
          "0941-1291", 
          "1436-2813"
        ], 
        "name": "Surgery Today", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "12", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "35"
      }
    ], 
    "keywords": [
      "IL-8 levels", 
      "COX-2 levels", 
      "cyclo-oxygenase-2", 
      "corpus mucosa", 
      "interleukin-8", 
      "stomach mucosa", 
      "remnant stomach", 
      "bile reflux", 
      "stomach carcinogenesis", 
      "Billroth-I anastomosis", 
      "Billroth II anastomosis", 
      "Helicobacter pylori infection", 
      "degree of inflammation", 
      "stomal mucosa", 
      "distal gastrectomy", 
      "I anastomosis", 
      "pylori infection", 
      "gastrointestinal endoscopy", 
      "risk factors", 
      "biopsy specimens", 
      "surrogate biomarker", 
      "patients", 
      "mucosa", 
      "anastomosis", 
      "TFF1 expression", 
      "infection", 
      "gastrectomy", 
      "stomach", 
      "reflux", 
      "biomarkers", 
      "carcinogenesis", 
      "association", 
      "expression", 
      "gene expression", 
      "levels", 
      "inflammation", 
      "endoscopy", 
      "stomata", 
      "risk", 
      "factors", 
      "differences", 
      "genes", 
      "specimens", 
      "BII", 
      "indicators", 
      "degree", 
      "detail", 
      "corpus"
    ], 
    "name": "Interleukin-8, Cyclo-oxygenase-2, and Trefoil Factor Family 1 Gene Expression and Their Association with Helicobacter pylori Infection in the Remnant Stomach", 
    "pagination": "1026-1032", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1031659818"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00595-005-3075-7"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16341482"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00595-005-3075-7", 
      "https://app.dimensions.ai/details/publication/pub.1031659818"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-12-01T06:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221201/entities/gbq_results/article/article_404.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00595-005-3075-7"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00595-005-3075-7'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00595-005-3075-7'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00595-005-3075-7'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00595-005-3075-7'


 

This table displays all metadata directly associated to this object as RDF triples.

279 TRIPLES      21 PREDICATES      101 URIs      88 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00595-005-3075-7 schema:about N2bdf9ff44f5449eba66ebb72950669a0
2 N351d02dc04974a2ba8f6b483307728b2
3 N3cee7ed1a0fc48ea9dbb65f6d99acdc3
4 N67a89005d6e64f5898921d94497d77cc
5 N6b3c13c1144747b0ae03b10a2e2ff8c7
6 N6c04d172efa5400fb6262b513de2edc5
7 N7a85985736e2454e9d2533f6b95ff2e7
8 N7ec29473f17e49ec958fc44818744d68
9 N8b6effbe31d14b31988642f90109facf
10 Nba00be0adfd74944a3b0cde939a0429f
11 Nc15ae1942dd446a98c30daf625922ac7
12 Nc5ed9edbb4044d8885bec7d249f0028e
13 Nc9969d167dbf4aca9b1d9cefb3234248
14 Nc9afeb5565dd41cf8cd61caaba9f6f7e
15 Nd4004a5245ce4c039b794825a4198a69
16 Nd4b24c0cf72d4e12aeb21f7bf0ff461f
17 Nd76a602ad0b54f9481913e908d9e3e82
18 Nda7448d61bce4c919fab24903d44fa99
19 Neb5ff229fe0a459183e300a8d5af8372
20 Nf2803abc53434aa3bc88e4b5a9c3adab
21 Nf2c8a73cbc4a4f5e87c59b162c417e51
22 Nfbc8d71eda3f419cbf5aa8d66e94969c
23 anzsrc-for:11
24 anzsrc-for:1103
25 schema:author N2c5f9c3ba21440b38547906bf4df876a
26 schema:citation sg:pub.10.1007/s00535-003-1337-y
27 sg:pub.10.1007/s005350050146
28 sg:pub.10.1007/s10120-003-0234-7
29 sg:pub.10.1038/35094017
30 sg:pub.10.1097/01.lab.0000029205.76632.a8
31 schema:datePublished 2005-12
32 schema:datePublishedReg 2005-12-01
33 schema:description PurposeThe risk factors for secondary stomach carcinogenesis after distal gastrectomy have not been evaluated in detail.MethodsUsing gastrointestinal endoscopy, we examined 112 patients who had undergone gastrectomy. Biopsy specimens were taken from the stoma and the upper corpus mucosa in the remnant stomach to examine the associations among Helicobacter pylori (H.pylori) infection, bile reflux, and the expressions of interleukin-8 (IL-8), cyclo-oxygenase-2 (COX-2), and trefoil factor family 1 (TFF1) genes in the stomach mucosa.ResultsThe IL-8 levels in the corpus mucosa were significantly higher in the H.pylori-positive patients than in the H.pylori-negative patients (P = 0.015). The IL-8 levels were significantly higher in the stomal mucosa than in the corpus mucosa in the H.pylori-positive patients (P = 0.047). The COX-2 levels in the corpus mucosa tended to be higher in the H.pylori-positive patients, but these levels were not significantly different in the stoma mucosa. The COX-2 levels in the corpus were significantly higher after Billroth II (BII) anastomosis than after Billroth I (BI) anastomosis (P = 0.041). TFF1 expression in the stoma was higher in the H.pylori-positive patients than in the H.pylori-negative patients, but the difference was not significant.ConclusionsBoth H.pylori infection and bile reflux increased IL-8 levels after BI anastomosis. Furthermore, COX-2 levels were higher after BII than after BI anastomosis. These indicators will become useful not only as biomarkers to predict the degree of inflammation in the stomach mucosa, but also as surrogate biomarkers to predict the risk of secondary stomach carcinogenesis in the remnant stomach mucosa.
34 schema:genre article
35 schema:isAccessibleForFree false
36 schema:isPartOf N2e469b519e1244d2abc3663a4fd5fb6e
37 N5624d9bc5d3f424581fc50d7ab806f8c
38 sg:journal.1102161
39 schema:keywords BII
40 Billroth II anastomosis
41 Billroth-I anastomosis
42 COX-2 levels
43 Helicobacter pylori infection
44 I anastomosis
45 IL-8 levels
46 TFF1 expression
47 anastomosis
48 association
49 bile reflux
50 biomarkers
51 biopsy specimens
52 carcinogenesis
53 corpus
54 corpus mucosa
55 cyclo-oxygenase-2
56 degree
57 degree of inflammation
58 detail
59 differences
60 distal gastrectomy
61 endoscopy
62 expression
63 factors
64 gastrectomy
65 gastrointestinal endoscopy
66 gene expression
67 genes
68 indicators
69 infection
70 inflammation
71 interleukin-8
72 levels
73 mucosa
74 patients
75 pylori infection
76 reflux
77 remnant stomach
78 risk
79 risk factors
80 specimens
81 stomach
82 stomach carcinogenesis
83 stomach mucosa
84 stomal mucosa
85 stomata
86 surrogate biomarker
87 schema:name Interleukin-8, Cyclo-oxygenase-2, and Trefoil Factor Family 1 Gene Expression and Their Association with Helicobacter pylori Infection in the Remnant Stomach
88 schema:pagination 1026-1032
89 schema:productId N5a114a4fa8cd47308a90ea7857ee0d76
90 N727edd760c644c2cb3f530342c65f277
91 Ne338c98185824587a8ba743aa8cfd3ca
92 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031659818
93 https://doi.org/10.1007/s00595-005-3075-7
94 schema:sdDatePublished 2022-12-01T06:25
95 schema:sdLicense https://scigraph.springernature.com/explorer/license/
96 schema:sdPublisher N3cd29fdb13354862a5bf25a9e89a815f
97 schema:url https://doi.org/10.1007/s00595-005-3075-7
98 sgo:license sg:explorer/license/
99 sgo:sdDataset articles
100 rdf:type schema:ScholarlyArticle
101 N0cea7152720d44599db9d258147a383f rdf:first sg:person.013557374312.17
102 rdf:rest N8734bb955d9748699e419a6c0bd32bd9
103 N2302914179b34713abb8b9fcff4d70db rdf:first sg:person.010407250562.21
104 rdf:rest N34d961468e554ade9c0d4f02ac879387
105 N2bdf9ff44f5449eba66ebb72950669a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Aged
107 rdf:type schema:DefinedTerm
108 N2c5f9c3ba21440b38547906bf4df876a rdf:first sg:person.0603665234.14
109 rdf:rest N0cea7152720d44599db9d258147a383f
110 N2e469b519e1244d2abc3663a4fd5fb6e schema:volumeNumber 35
111 rdf:type schema:PublicationVolume
112 N34d961468e554ade9c0d4f02ac879387 rdf:first sg:person.01303445622.71
113 rdf:rest Nde9979101f1f4a069c480a0f153afdd9
114 N351d02dc04974a2ba8f6b483307728b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Middle Aged
116 rdf:type schema:DefinedTerm
117 N3cd29fdb13354862a5bf25a9e89a815f schema:name Springer Nature - SN SciGraph project
118 rdf:type schema:Organization
119 N3cee7ed1a0fc48ea9dbb65f6d99acdc3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Gastroscopy
121 rdf:type schema:DefinedTerm
122 N5624d9bc5d3f424581fc50d7ab806f8c schema:issueNumber 12
123 rdf:type schema:PublicationIssue
124 N5a114a4fa8cd47308a90ea7857ee0d76 schema:name doi
125 schema:value 10.1007/s00595-005-3075-7
126 rdf:type schema:PropertyValue
127 N67a89005d6e64f5898921d94497d77cc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Cyclooxygenase 2
129 rdf:type schema:DefinedTerm
130 N6b3c13c1144747b0ae03b10a2e2ff8c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Helicobacter pylori
132 rdf:type schema:DefinedTerm
133 N6c04d172efa5400fb6262b513de2edc5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Polymerase Chain Reaction
135 rdf:type schema:DefinedTerm
136 N727edd760c644c2cb3f530342c65f277 schema:name pubmed_id
137 schema:value 16341482
138 rdf:type schema:PropertyValue
139 N7a85985736e2454e9d2533f6b95ff2e7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Humans
141 rdf:type schema:DefinedTerm
142 N7ec29473f17e49ec958fc44818744d68 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Male
144 rdf:type schema:DefinedTerm
145 N8734bb955d9748699e419a6c0bd32bd9 rdf:first sg:person.0756125372.33
146 rdf:rest Nb7e6ca2bc3314715af55687c05dc1f27
147 N8b6effbe31d14b31988642f90109facf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Predictive Value of Tests
149 rdf:type schema:DefinedTerm
150 N94d67e5c0bb241f385d040da0436cd6e rdf:first sg:person.01362562045.19
151 rdf:rest Naf7db736756d4ee09ea3edf8a6f74d44
152 Naf7db736756d4ee09ea3edf8a6f74d44 rdf:first sg:person.0624354200.40
153 rdf:rest N2302914179b34713abb8b9fcff4d70db
154 Nb7e6ca2bc3314715af55687c05dc1f27 rdf:first sg:person.01001526627.05
155 rdf:rest N94d67e5c0bb241f385d040da0436cd6e
156 Nba00be0adfd74944a3b0cde939a0429f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Aged, 80 and over
158 rdf:type schema:DefinedTerm
159 Nc15ae1942dd446a98c30daf625922ac7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Bile Reflux
161 rdf:type schema:DefinedTerm
162 Nc5ed9edbb4044d8885bec7d249f0028e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Helicobacter Infections
164 rdf:type schema:DefinedTerm
165 Nc9969d167dbf4aca9b1d9cefb3234248 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Gastric Stump
167 rdf:type schema:DefinedTerm
168 Nc9afeb5565dd41cf8cd61caaba9f6f7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Female
170 rdf:type schema:DefinedTerm
171 Nd4004a5245ce4c039b794825a4198a69 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Adult
173 rdf:type schema:DefinedTerm
174 Nd4b24c0cf72d4e12aeb21f7bf0ff461f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Trefoil Factor-1
176 rdf:type schema:DefinedTerm
177 Nd76a602ad0b54f9481913e908d9e3e82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
178 schema:name Risk Factors
179 rdf:type schema:DefinedTerm
180 Nda7448d61bce4c919fab24903d44fa99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Biomarkers, Tumor
182 rdf:type schema:DefinedTerm
183 Nde9979101f1f4a069c480a0f153afdd9 rdf:first sg:person.01357202667.08
184 rdf:rest rdf:nil
185 Ne338c98185824587a8ba743aa8cfd3ca schema:name dimensions_id
186 schema:value pub.1031659818
187 rdf:type schema:PropertyValue
188 Neb5ff229fe0a459183e300a8d5af8372 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
189 schema:name Gastrectomy
190 rdf:type schema:DefinedTerm
191 Nf2803abc53434aa3bc88e4b5a9c3adab schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Tumor Suppressor Proteins
193 rdf:type schema:DefinedTerm
194 Nf2c8a73cbc4a4f5e87c59b162c417e51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Stomach Neoplasms
196 rdf:type schema:DefinedTerm
197 Nfbc8d71eda3f419cbf5aa8d66e94969c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Interleukin-8
199 rdf:type schema:DefinedTerm
200 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
201 schema:name Medical and Health Sciences
202 rdf:type schema:DefinedTerm
203 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
204 schema:name Clinical Sciences
205 rdf:type schema:DefinedTerm
206 sg:journal.1102161 schema:issn 0941-1291
207 1436-2813
208 schema:name Surgery Today
209 schema:publisher Springer Nature
210 rdf:type schema:Periodical
211 sg:person.01001526627.05 schema:affiliation grid-institutes:grid.410821.e
212 schema:familyName Matsuda
213 schema:givenName Noriko
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01001526627.05
215 rdf:type schema:Person
216 sg:person.010407250562.21 schema:affiliation grid-institutes:grid.410821.e
217 schema:familyName Yamada
218 schema:givenName Nobutaka
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010407250562.21
220 rdf:type schema:Person
221 sg:person.01303445622.71 schema:affiliation grid-institutes:grid.410821.e
222 schema:familyName Naito
223 schema:givenName Zenya
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01303445622.71
225 rdf:type schema:Person
226 sg:person.013557374312.17 schema:affiliation grid-institutes:grid.410821.e
227 schema:familyName Kato
228 schema:givenName Shunji
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013557374312.17
230 rdf:type schema:Person
231 sg:person.01357202667.08 schema:affiliation grid-institutes:grid.410821.e
232 schema:familyName Tajiri
233 schema:givenName Takashi
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357202667.08
235 rdf:type schema:Person
236 sg:person.01362562045.19 schema:affiliation grid-institutes:grid.412636.4
237 schema:familyName Xu
238 schema:givenName Huimian
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362562045.19
240 rdf:type schema:Person
241 sg:person.0603665234.14 schema:affiliation grid-institutes:grid.412636.4
242 schema:familyName Xing
243 schema:givenName Chengzhong
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0603665234.14
245 rdf:type schema:Person
246 sg:person.0624354200.40 schema:affiliation grid-institutes:grid.410821.e
247 schema:familyName Takashi
248 schema:givenName En
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624354200.40
250 rdf:type schema:Person
251 sg:person.0756125372.33 schema:affiliation grid-institutes:grid.410821.e
252 schema:familyName Matsukura
253 schema:givenName Norio
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756125372.33
255 rdf:type schema:Person
256 sg:pub.10.1007/s00535-003-1337-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1036045475
257 https://doi.org/10.1007/s00535-003-1337-y
258 rdf:type schema:CreativeWork
259 sg:pub.10.1007/s005350050146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010257475
260 https://doi.org/10.1007/s005350050146
261 rdf:type schema:CreativeWork
262 sg:pub.10.1007/s10120-003-0234-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075315784
263 https://doi.org/10.1007/s10120-003-0234-7
264 rdf:type schema:CreativeWork
265 sg:pub.10.1038/35094017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002632915
266 https://doi.org/10.1038/35094017
267 rdf:type schema:CreativeWork
268 sg:pub.10.1097/01.lab.0000029205.76632.a8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049326123
269 https://doi.org/10.1097/01.lab.0000029205.76632.a8
270 rdf:type schema:CreativeWork
271 grid-institutes:grid.410821.e schema:alternateName Department of Integrative Pathology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, Japan
272 Department of Surgery for Organ Function and Biological Regulation, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, Japan
273 schema:name Department of Integrative Pathology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, Japan
274 Department of Surgery for Organ Function and Biological Regulation, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, Japan
275 rdf:type schema:Organization
276 grid-institutes:grid.412636.4 schema:alternateName Department of Oncology, First Hospital of China Medical University, Shengyang, China
277 schema:name Department of Oncology, First Hospital of China Medical University, Shengyang, China
278 Department of Surgery for Organ Function and Biological Regulation, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, 113-8603, Tokyo, Japan
279 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...