Ontology type: schema:ScholarlyArticle
2005-06
AUTHORSKouhei Fukushima, Shun Sato, Hiroo Naito, Yuji Funayama, Chikashi Shibata, Iwao Sasaki
ABSTRACTThe water and electrolyte balance is regulated by the renin-angiotensin-aldosterone system in the kidney. We previously reported that the levels of circulating aldosterone dramatically increased following a total proctocolectomy in rats. However, there is no direct evidence regarding whether renal adaptation is accelerated by the induction of aldosterone-associated molecules. To explore this question, Sprague-Dawley rats underwent total proctocolectomies and then were killed 8 weeks later. We investigated the renal expression of 11β-hydroxysteroid dehydrogenase type 2, the α-, β-, and γ-subunits of the epithelial sodium channel, and the α1- and β1-subunits of Na+,K+-ATPase mRNAs because those molecules are responsible for the aldosterone specificity for mineralocorticoid receptor, amiloride-sensitive sodium absorption, and sodium extrusion from distal tubules, respectively. A Northern blot analysis demonstrated the kidney to exhibit mRNA induction for all of these molecules, thus supporting the idea that renal adaptation following a total proctocolectomy depends, at least in part, upon the molecular induction which is principally regulated by circulating aldosterone. More... »
PAGES502-504
http://scigraph.springernature.com/pub.10.1007/s00595-004-2971-6
DOIhttp://dx.doi.org/10.1007/s00595-004-2971-6
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/15912302
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