Ontology type: schema:ScholarlyArticle
2005-06
AUTHORSKouhei Fukushima, Shun Sato, Hiroo Naito, Yuji Funayama, Chikashi Shibata, Iwao Sasaki
ABSTRACTThe water and electrolyte balance is regulated by the renin-angiotensin-aldosterone system in the kidney. We previously reported that the levels of circulating aldosterone dramatically increased following a total proctocolectomy in rats. However, there is no direct evidence regarding whether renal adaptation is accelerated by the induction of aldosterone-associated molecules. To explore this question, Sprague-Dawley rats underwent total proctocolectomies and then were killed 8 weeks later. We investigated the renal expression of 11β-hydroxysteroid dehydrogenase type 2, the α-, β-, and γ-subunits of the epithelial sodium channel, and the α1- and β1-subunits of Na+,K+-ATPase mRNAs because those molecules are responsible for the aldosterone specificity for mineralocorticoid receptor, amiloride-sensitive sodium absorption, and sodium extrusion from distal tubules, respectively. A Northern blot analysis demonstrated the kidney to exhibit mRNA induction for all of these molecules, thus supporting the idea that renal adaptation following a total proctocolectomy depends, at least in part, upon the molecular induction which is principally regulated by circulating aldosterone. More... »
PAGES502-504
http://scigraph.springernature.com/pub.10.1007/s00595-004-2971-6
DOIhttp://dx.doi.org/10.1007/s00595-004-2971-6
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1010617919
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/15912302
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "11-beta-Hydroxysteroid Dehydrogenase Type 2",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adaptation, Physiological",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Blotting, Northern",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Epithelial Cells",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Epithelial Sodium Channels",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gene Expression",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunohistochemistry",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Kidney",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Postoperative Period",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Proctocolectomy, Restorative",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "RNA, Messenger",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rats",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rats, Sprague-Dawley",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Renin-Angiotensin System",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sodium Channels",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Surgery, Tohoku University, Graduate School of Medicine, 1-1 Seiryomachi, Aoba-ku, 980-8574, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Department of Surgery, Tohoku University, Graduate School of Medicine, 1-1 Seiryomachi, Aoba-ku, 980-8574, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Fukushima",
"givenName": "Kouhei",
"id": "sg:person.01334453724.73",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334453724.73"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Surgery, Tohoku University, Graduate School of Medicine, 1-1 Seiryomachi, Aoba-ku, 980-8574, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Department of Surgery, Tohoku University, Graduate School of Medicine, 1-1 Seiryomachi, Aoba-ku, 980-8574, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Sato",
"givenName": "Shun",
"id": "sg:person.014135112102.35",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014135112102.35"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Surgery, Tohoku University, Graduate School of Medicine, 1-1 Seiryomachi, Aoba-ku, 980-8574, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Department of Surgery, Tohoku University, Graduate School of Medicine, 1-1 Seiryomachi, Aoba-ku, 980-8574, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Naito",
"givenName": "Hiroo",
"id": "sg:person.0646146351.47",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646146351.47"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Surgery, Tohoku University, Graduate School of Medicine, 1-1 Seiryomachi, Aoba-ku, 980-8574, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Department of Surgery, Tohoku University, Graduate School of Medicine, 1-1 Seiryomachi, Aoba-ku, 980-8574, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Funayama",
"givenName": "Yuji",
"id": "sg:person.0607610424.09",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0607610424.09"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Surgery, Tohoku University, Graduate School of Medicine, 1-1 Seiryomachi, Aoba-ku, 980-8574, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Department of Surgery, Tohoku University, Graduate School of Medicine, 1-1 Seiryomachi, Aoba-ku, 980-8574, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Shibata",
"givenName": "Chikashi",
"id": "sg:person.0623155434.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0623155434.08"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Surgery, Tohoku University, Graduate School of Medicine, 1-1 Seiryomachi, Aoba-ku, 980-8574, Sendai, Japan",
"id": "http://www.grid.ac/institutes/grid.69566.3a",
"name": [
"Department of Surgery, Tohoku University, Graduate School of Medicine, 1-1 Seiryomachi, Aoba-ku, 980-8574, Sendai, Japan"
],
"type": "Organization"
},
"familyName": "Sasaki",
"givenName": "Iwao",
"id": "sg:person.0637241324.72",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637241324.72"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/bf02987076",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037936283",
"https://doi.org/10.1007/bf02987076"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1018807524075",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011626093",
"https://doi.org/10.1023/a:1018807524075"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf00337584",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030575298",
"https://doi.org/10.1007/bf00337584"
],
"type": "CreativeWork"
}
],
"datePublished": "2005-06",
"datePublishedReg": "2005-06-01",
"description": "The water and electrolyte balance is regulated by the renin-angiotensin-aldosterone system in the kidney. We previously reported that the levels of circulating aldosterone dramatically increased following a total proctocolectomy in rats. However, there is no direct evidence regarding whether renal adaptation is accelerated by the induction of aldosterone-associated molecules. To explore this question, Sprague-Dawley rats underwent total proctocolectomies and then were killed 8 weeks later. We investigated the renal expression of 11\u03b2-hydroxysteroid dehydrogenase type 2, the \u03b1-, \u03b2-, and \u03b3-subunits of the epithelial sodium channel, and the \u03b11- and \u03b21-subunits of Na+,K+-ATPase mRNAs because those molecules are responsible for the aldosterone specificity for mineralocorticoid receptor, amiloride-sensitive sodium absorption, and sodium extrusion from distal tubules, respectively. A Northern blot analysis demonstrated the kidney to exhibit mRNA induction for all of these molecules, thus supporting the idea that renal adaptation following a total proctocolectomy depends, at least in part, upon the molecular induction which is principally regulated by circulating aldosterone.",
"genre": "article",
"id": "sg:pub.10.1007/s00595-004-2971-6",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1102161",
"issn": [
"0941-1291",
"1436-2813"
],
"name": "Surgery Today",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "6",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "35"
}
],
"keywords": [
"total proctocolectomy",
"renal expression",
"renal adaptation",
"amiloride-sensitive sodium absorption",
"Sprague-Dawley rats",
"dehydrogenase type 2",
"aldosterone system",
"epithelial sodium channel",
"aldosterone specificity",
"mineralocorticoid receptor",
"distal tubules",
"electrolyte balance",
"proctocolectomy",
"type 2",
"sodium absorption",
"sodium transport",
"sodium channels",
"rats",
"aldosterone",
"ATPase mRNA",
"mRNA induction",
"\u03b21 subunit",
"Northern blot analysis",
"blot analysis",
"kidney",
"induction",
"sodium extrusion",
"expression",
"direct evidence",
"molecular induction",
"weeks",
"receptors",
"tubules",
"mRNA",
"\u03b11",
"specificity",
"evidence",
"levels",
"genes",
"molecules",
"adaptation",
"subunits",
"balance",
"analysis",
"part",
"questions",
"absorption",
"essential genes",
"extrusion",
"channels",
"transport",
"system",
"water",
"idea"
],
"name": "Renal Expression of the Essential Genes Associated with Sodium Transport Following a Total Proctocolectomy in Rats",
"pagination": "502-504",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1010617919"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00595-004-2971-6"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"15912302"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00595-004-2971-6",
"https://app.dimensions.ai/details/publication/pub.1010617919"
],
"sdDataset": "articles",
"sdDatePublished": "2022-06-01T22:04",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220601/entities/gbq_results/article/article_408.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s00595-004-2971-6"
}
]
Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00595-004-2971-6'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00595-004-2971-6'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00595-004-2971-6'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00595-004-2971-6'
This table displays all metadata directly associated to this object as RDF triples.
231 TRIPLES
22 PREDICATES
101 URIs
90 LITERALS
24 BLANK NODES