Pancreatic β-cell dysfunction in normoglycemic patients and risk factors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-08-29

AUTHORS

Luis H. Vilchis-Flores, Georgina A. Barajas-Medina, Ana Karen Villa-Martínez, Sara S. Salazar López, Gabriela A. Luna-Patiño, María Elena Quiroz-Hernández, María Alejandra Guzmán-Vanegas, Rafael Rodríguez-Cortes, Fabiola Angulo-Romero, Ma. De Lourdes Reyes-Escogido, Alberto Aguilar-García, Lilia M. Jiménez-Ceja, Franco Folli, Rodolfo Guardado-Mendoza

ABSTRACT

AimsTo evaluate pancreatic β-cell function (βf) in patients with normoglycemia (NG) and normal glucose tolerance (NGT) and related risk factors.MethodsAn observational and comparative study in 527 patients with NG and NGT that were divided by quartiles of βf according to the disposition index derived from OGTT. Anthropometrical, clinical, nutritional, and biochemical variables were measured and associated with βf.ResultsQuartiles of βf were Q1 = DI < 1.93 n = 131, Q2 = DI 1.93–2.45 n = 134, Q3 = DI 2.46–3.1 n = 133, and Q4 = DI > 3.1 n = 129. There was a progressive reduction in pancreatic β-cell function and it is negatively correlated with age, weight, BMI, total body fat and visceral fat, waist circumference, total cholesterol, LDL, and triglycerides (p < 0.01). Glucose levels during OGTT had a negative correlation with βf; the product of fasting glucose by 1-h glucose had the best correlation with βf (r = 0.611, p < 0.001) and was the best predictor of βdf (AUC 0.816, CI 95% 0.774–0.857), even better than 1-h glucose (r = 0.581, p < 0.001). Energy, fat, and carbohydrate intake were negatively correlated with βf (p < 0.05). Glucose levels at 1-h OGTT > 110 mg/dl were positively associated with pancreatic βdf (OR 6.85, CI 95% 3.86–12.4). In the multivariate analysis, glucose levels during OGTT, fasting insulin, and BMI were the main factors associated with βf.ConclusionsA subgroup of patients with NG and NGT may have a loss of 40% of their βf. Factors related to this βdf were age, adiposity, glucose during OGTT, and the product of fasting and 1-h glucose, as well as food intake. More... »

PAGES

1305-1314

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00592-019-01411-9

DOI

http://dx.doi.org/10.1007/s00592-019-01411-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1120687656

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31468201


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31 schema:description AimsTo evaluate pancreatic β-cell function (βf) in patients with normoglycemia (NG) and normal glucose tolerance (NGT) and related risk factors.MethodsAn observational and comparative study in 527 patients with NG and NGT that were divided by quartiles of βf according to the disposition index derived from OGTT. Anthropometrical, clinical, nutritional, and biochemical variables were measured and associated with βf.ResultsQuartiles of βf were Q1 = DI < 1.93 n = 131, Q2 = DI 1.93–2.45 n = 134, Q3 = DI 2.46–3.1 n = 133, and Q4 = DI > 3.1 n = 129. There was a progressive reduction in pancreatic β-cell function and it is negatively correlated with age, weight, BMI, total body fat and visceral fat, waist circumference, total cholesterol, LDL, and triglycerides (p < 0.01). Glucose levels during OGTT had a negative correlation with βf; the product of fasting glucose by 1-h glucose had the best correlation with βf (r = 0.611, p < 0.001) and was the best predictor of βdf (AUC 0.816, CI 95% 0.774–0.857), even better than 1-h glucose (r = 0.581, p < 0.001). Energy, fat, and carbohydrate intake were negatively correlated with βf (p < 0.05). Glucose levels at 1-h OGTT > 110 mg/dl were positively associated with pancreatic βdf (OR 6.85, CI 95% 3.86–12.4). In the multivariate analysis, glucose levels during OGTT, fasting insulin, and BMI were the main factors associated with βf.ConclusionsA subgroup of patients with NG and NGT may have a loss of 40% of their βf. Factors related to this βdf were age, adiposity, glucose during OGTT, and the product of fasting and 1-h glucose, as well as food intake.
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38 BMI
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40 MethodsAn
41 OGTT
42 Q1
43 Q2
44 Q3
45 Q4
46 adiposity
47 age
48 analysis
49 best predictor
50 biochemical variables
51 body fat
52 carbohydrate intake
53 cholesterol
54 circumference
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57 di
58 disposition index
59 dl
60 dysfunction
61 energy
62 factors
63 fat
64 food intake
65 function
66 glucose
67 glucose levels
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69 good correlation
70 index
71 insulin
72 intake
73 levels
74 loss
75 main factors
76 multivariate analysis
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79 normoglycemia
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81 pancreatic β-cell dysfunction
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85 products
86 progressive reduction
87 quartile
88 reduction
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93 total body fat
94 total cholesterol
95 triglycerides
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