Effect of lifestyle improvement program on the biomarkers of adiposity, inflammation and gut hormones in overweight/obese Asian Indians with prediabetes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-06-15

AUTHORS

Kuppan Gokulakrishnan, Harish Ranjani, Mary Beth Weber, Gautam Kumar Pandey, Ranjit Mohan Anjana, Muthuswamy Balasubramanyam, Dorairaj Prabhakaran, Nikhil Tandon, K. M. Narayan, Viswanathan Mohan

ABSTRACT

AimsWhile lifestyle modification is known to offer several metabolic benefits, there is paucity of comprehensive data on changes in biomarkers of adiposity, inflammation as well as gut hormones. We investigated these biomarkers in overweight/obese individuals with prediabetes randomized to either 4 months of a lifestyle improvement program or standard care and followed them up for a year.MethodsParticipants [standard care and intervention arm (n = 75 each)] were randomly selected from the Diabetes Community Lifestyle Improvement Program trial. Glycemic and lipid control and anthropometric measurements were assessed by standard protocols. Adipokines, inflammatory markers and gut hormones were measured using multiplex and standard ELISA kits.Results Along with modest benefits in primary outcomes (glycemic and lipid control and weight reduction), participants in the intervention group showed significant reductions (p < 0.001) in plasma levels of leptin (17.6%), TNF-α (35%), IL-6 (33.3%), MCP-1 (22.3%) and PYY (28.3%) and increased levels of adiponectin (33.1%) and ghrelin (23.6%) at the end of 4 months of lifestyle intervention. The changes were independent of weight and persisted even at 1 year of follow-up. In contrast, participants from the standard care arm did not show any statistically significant improvements on the above parameters.ConclusionsParticipants who underwent an intensive lifestyle improvement program showed metabolic benefits as well as favorable beneficial changes in systemic levels of adipokines, cytokines and gut hormones, not only during the intervention period, but also during 12-month follow-up period. More... »

PAGES

843-852

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00592-017-1015-9

DOI

http://dx.doi.org/10.1007/s00592-017-1015-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1086041849

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28620678


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34 schema:description AimsWhile lifestyle modification is known to offer several metabolic benefits, there is paucity of comprehensive data on changes in biomarkers of adiposity, inflammation as well as gut hormones. We investigated these biomarkers in overweight/obese individuals with prediabetes randomized to either 4 months of a lifestyle improvement program or standard care and followed them up for a year.MethodsParticipants [standard care and intervention arm (n = 75 each)] were randomly selected from the Diabetes Community Lifestyle Improvement Program trial. Glycemic and lipid control and anthropometric measurements were assessed by standard protocols. Adipokines, inflammatory markers and gut hormones were measured using multiplex and standard ELISA kits.Results Along with modest benefits in primary outcomes (glycemic and lipid control and weight reduction), participants in the intervention group showed significant reductions (p < 0.001) in plasma levels of leptin (17.6%), TNF-α (35%), IL-6 (33.3%), MCP-1 (22.3%) and PYY (28.3%) and increased levels of adiponectin (33.1%) and ghrelin (23.6%) at the end of 4 months of lifestyle intervention. The changes were independent of weight and persisted even at 1 year of follow-up. In contrast, participants from the standard care arm did not show any statistically significant improvements on the above parameters.ConclusionsParticipants who underwent an intensive lifestyle improvement program showed metabolic benefits as well as favorable beneficial changes in systemic levels of adipokines, cytokines and gut hormones, not only during the intervention period, but also during 12-month follow-up period.
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40 schema:keywords Asian Indians
41 ConclusionsParticipants
42 ELISA kit
43 IL-6
44 Indians
45 Lifestyle Improvement Program
46 MCP-1
47 MethodsParticipants
48 PYY
49 Program trial
50 TNF
51 above parameters
52 adipokines
53 adiponectin
54 adiposity
55 anthropometric measurements
56 arm
57 beneficial changes
58 benefits
59 biomarkers
60 biomarkers of adiposity
61 care
62 care arm
63 changes
64 comprehensive data
65 contrast
66 control
67 cytokines
68 data
69 effect
70 end
71 follow
72 ghrelin
73 group
74 gut
75 gut hormones
76 hormone
77 improvement
78 improvement programs
79 individuals
80 inflammation
81 inflammatory markers
82 intervention
83 intervention group
84 intervention period
85 kit
86 leptin
87 levels
88 levels of adiponectin
89 lifestyle intervention
90 lifestyle modification
91 lipid control
92 markers
93 measurements
94 metabolic benefits
95 modest benefit
96 modification
97 months
98 multiplex
99 obese Asian Indians
100 obese individuals
101 outcomes
102 overweight/obese individuals
103 parameters
104 participants
105 paucity
106 period
107 plasma levels
108 prediabetes
109 primary outcome
110 program
111 protocol
112 reduction
113 results
114 significant improvement
115 significant reduction
116 standard ELISA kits
117 standard care
118 standard care arm
119 standard protocol
120 systemic levels
121 trials
122 weight
123 years
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