Association between insulin secretion, insulin sensitivity and type 2 diabetes susceptibility variants identified in genome-wide association studies View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-09

AUTHORS

Stephanie-May Ruchat, Cathy E. Elks, Ruth J. F. Loos, Marie-Claude Vohl, S. John Weisnagel, Tuomo Rankinen, Claude Bouchard, Louis Pérusse

ABSTRACT

Several single nucleotide polymorphisms (SNPs) for type 2 diabetes mellitus (T2DM) risk have been identified by genome wide association studies (GWAS). The objective of the present study was to investigate the impact of these SNPs on T2DM intermediate phenotypes in order to clarify the physiological mechanisms through which they exert their effects on disease etiology. We analysed 23 SNPs in 9 T2DM genes (CDKAL1, CDKN2B, HHEX/IDE, IGF2BP2, KCNJ11, SLC30A8, TCF2, TCF7L2 and WFS1) in a maximum of 712 men and women from the Quebec Family Study. The participants underwent a 75 g oral glucose tolerance test (OGTT) and were measured for glucose, insulin and C-peptide levels. Indices of insulin sensitivity and insulin secretion were derived from fasting and OGTT measurements. We confirmed the significant associations of variants in CDKAL1, CDKN2B, HHEX/IDE, KCNJ11 and TCF7L2 with insulin secretion and also found associations of some of these variants with insulin sensitivity and glucose tolerance. IGF2BP2 and SLC30A8 SNPs were not associated with insulin secretion but were with insulin sensitivity and glucose tolerance (0.002 More... »

PAGES

217

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00592-008-0080-5

    DOI

    http://dx.doi.org/10.1007/s00592-008-0080-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1016418845

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19082521


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