Prothrombin time-international normalized ratio is a useful marker for edoxaban efficacy in preventing venous thromboembolism after total knee arthroplasty View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-08-01

AUTHORS

Kazuki Kodato, Kazunari Ishida, Nao Shibanuma, Akihiko Toda, Koji Takayama, Shinya Oka, Shinya Hayashi, Shingo Hashimoto, Masahiro Kurosaka, Ryosuke Kuroda, Tomoyuki Matsumoto

ABSTRACT

BackgroundDeep vein thrombosis (DVT) is one of the main complications following total knee arthroplasty (TKA). In this study, oral administration of 15 mg edoxaban (a factor Xa inhibitor) once daily for 14 days efficiently prevented the incidence of DVT. Our hypothesis was that prothrombin time-international normalized ratio (PT-INR) on the third postoperative day could predict the incidence of DVT following TKA.MethodsIn this study, 286 subjects were enrolled and divided into two groups according to the presence or absence of DVT. Several variables [age, body mass index, postoperative D-dimer level, PT-INR, and functional recovery findings (standing)] were analysed to determine the predictors of DVT, and for DVT diagnosis, ultrasonography was performed for seven days after surgery.ResultsThe PT-INR levels were significantly higher in the group that did not develop DVT (p = 0.01). Further analysis with logistic regression analysis and receiver operating characteristic curve was performed. The PT-INR on the third postoperative day was an independent factor of the incidence of DVT (odds ratio 0.210; p = 0.035). The cut-off PT-INR was calculated to be 1.425.ConclusionPT-INR level is a useful marker in determining whether 15 mg edoxaban administration can prevent DVT after TKA. It is suggested that increment of edoxaban to control PT-INR over the cut-off point might prevent the incidence of DVT. More... »

PAGES

103-108

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00590-017-2018-5

DOI

http://dx.doi.org/10.1007/s00590-017-2018-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1090937061

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28766070


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31 schema:description BackgroundDeep vein thrombosis (DVT) is one of the main complications following total knee arthroplasty (TKA). In this study, oral administration of 15 mg edoxaban (a factor Xa inhibitor) once daily for 14 days efficiently prevented the incidence of DVT. Our hypothesis was that prothrombin time-international normalized ratio (PT-INR) on the third postoperative day could predict the incidence of DVT following TKA.MethodsIn this study, 286 subjects were enrolled and divided into two groups according to the presence or absence of DVT. Several variables [age, body mass index, postoperative D-dimer level, PT-INR, and functional recovery findings (standing)] were analysed to determine the predictors of DVT, and for DVT diagnosis, ultrasonography was performed for seven days after surgery.ResultsThe PT-INR levels were significantly higher in the group that did not develop DVT (p = 0.01). Further analysis with logistic regression analysis and receiver operating characteristic curve was performed. The PT-INR on the third postoperative day was an independent factor of the incidence of DVT (odds ratio 0.210; p = 0.035). The cut-off PT-INR was calculated to be 1.425.ConclusionPT-INR level is a useful marker in determining whether 15 mg edoxaban administration can prevent DVT after TKA. It is suggested that increment of edoxaban to control PT-INR over the cut-off point might prevent the incidence of DVT.
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38 schema:keywords BackgroundDeep vein thrombosis
39 DVT
40 DVT diagnosis
41 Further analysis
42 MethodsIn
43 PT-INR levels
44 ResultsThe PT-INR levels
45 absence
46 absence of DVT
47 administration
48 analysis
49 arthroplasty
50 characteristic curve
51 complications
52 curves
53 days
54 diagnosis
55 edoxaban
56 edoxaban administration
57 edoxaban efficacy
58 efficacy
59 factors
60 group
61 hypothesis
62 incidence
63 incidence of DVT
64 increment
65 increment of edoxaban
66 independent factors
67 knee arthroplasty
68 levels
69 logistic regression analysis
70 main complications
71 markers
72 normalized ratio
73 oral administration
74 point
75 postoperative day
76 predictors
77 predictors of DVT
78 presence
79 prothrombin time-international normalized ratio
80 ratio
81 receiver
82 regression analysis
83 study
84 subjects
85 surgery
86 third postoperative day
87 thromboembolism
88 thrombosis
89 time-international normalized ratio
90 total knee arthroplasty
91 ultrasonography
92 useful marker
93 variables
94 vein thrombosis
95 venous thromboembolism
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