Single-center, consecutive series study of the use of a novel platelet-rich fibrin matrix (PRFM) and beta-tricalcium phosphate in posterolateral lumbar ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-12-03

AUTHORS

Tucker C. Callanan, Antonio T. Brecevich, Craig D. Steiner, Fred Xavier, Justin A. Iorio, Celeste Abjornson, Frank P. Cammisa

ABSTRACT

PurposeTo evaluate the radiographic and clinical outcomes of the combination of platelet-rich fibrin matrix (PRFM) with beta-tricalcium phosphate (β-TCP) and bone marrow aspirate (BMA) as a graft alternative in posterolateral lumbar fusion procedures.MethodsResearchers evaluated 50 consecutive patients undergoing one-level to three-level posterolateral lumbar fusion procedures, resulting in a total of 66 operated levels. The primary outcome was evidence of radiographic fusion at 1-year follow-up, assessed by three independent evaluators using the Lenke scoring system. Secondary outcomes included back and leg VAS scores, incidence of reoperations and complications, return-to-work status, and opioid use.ResultsAt 1-year follow-up, radiographic fusion was observed in 92.4% (61/66) of operated levels. There was significant improvement in VAS scores for both back and leg pain (p < 0.05). Compared to baseline figures, the number of patients using opioid analgesics at 12-months decreased by 38%. The majority (31/50) of patients were retired, yet 68% of employed patients (n = 19) were able to return to work. No surgical site infections were noted, and no revision surgery at the operated level was required.ConclusionsThis is the first report to analyze the combination of PRFM with β-TCP and BMA for PLF procedures. Our results indicate a rate of fusion similar to those reported using iliac crest bone graft (ICBG), while avoiding donor site morbidity related to ICBG harvesting such as hematoma, pain, and infection.Graphical abstractThese slides can be retrieved under Electronic Supplementary Material. More... »

PAGES

719-726

References to SciGraph publications

  • 2015-03-21. A Systematic Assessment of the Use of Platelet-Rich Plasma in Spinal Fusion in ANNALS OF BIOMEDICAL ENGINEERING
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    http://scigraph.springernature.com/pub.10.1007/s00586-018-5832-5

    DOI

    http://dx.doi.org/10.1007/s00586-018-5832-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1110344430

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30511243


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