Ewing sarcoma of the thoracic epidural space in a young child View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-05

AUTHORS

Shinsuke Kobayashi, Jun Takahashi, Kazuo Sakashita, Mana Fukushima, Hiroyuki Kato

ABSTRACT

PURPOSE: To report on the clinical course and treatment of Ewing sarcoma of the thoracic epidural space in a 5-year-old girl. METHODS: We present the case of a 5-year-old girl who experienced back pain (day 1); on day 10, the pain had exacerbated and involuntary movements in the lower limbs occurred, and an MRI performed in her local hospital revealed a tumor lesion at the upper thoracic level. RESULTS: On day 13, emergency surgery was performed for partial resection of the tumor. Pathological examination of the resected tumor by immunostaining and gene testing revealed that it was MIC2 positive and an EWS-FLI 1 chimera, respectively, and Ewing sarcoma was diagnosed. The involuntary movements resolved immediately after the surgery. Three weeks after the operation, chemotherapy and radiation therapy were commenced. After 5 months, deep tendon reflexes recovered to normal. MRI showed that the tumor has not recurred at 29 months after surgery. CONCLUSIONS: The majority of epidural patients undergo emergency surgery only after symptom exacerbation, which includes the development of neurological deficits. Thus, preoperative diagnosis of Ewing sarcoma of the epidural space is difficult and diagnosis is frequently made by a post-operative gene test. The resection area is limited to the intralesional margin area because a larger resection is difficult due to the characteristics of the affected region; thus, there is a higher possibility of recurrence and careful follow-up of the case is necessary. More... »

PAGES

373-379

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00586-012-2481-y

DOI

http://dx.doi.org/10.1007/s00586-012-2481-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049348768

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22907727


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