Trichostatin A (TSA) levels in response to treatment of rainbow trout with gamma-irradiated trophonts against Ichthyophthirius multifiliis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-04

AUTHORS

Saeed Moodi, Sakineh Yeganeh, Marzieh Heidarieh, Omid Safari

ABSTRACT

Ichthyophthirius multifiliis is a large ciliated protozoan parasite that is widely distributed in freshwater fish. Histone deacetylase inhibitors (HDACi), e.g., trichostatin A (TSA), are recognized as new agents for the treatment of a wide range of parasitic diseases. In this study, TSA levels induced by gamma-irradiated trophonts and alginate/calcium phosphate nanoparticles were measured after 30 days following treatment against I. multifiliis in spleen, kidney, and liver tissues of rainbow trout. This sounds like TSA is an anti-parasitic enzyme that can increase in spleen, kidney, and liver tissues following treatment of rainbow trout against I. multifiliis (P < 0.05). Moreover, the results obtained from this study showed that the TSA activity level is tissue-dependent. The highest significance levels for TSA activity were found in spleen tissue of treated and healthy groups compared with the levels of the both liver and kidney tissues (P < 0.05). More... »

PAGES

571-574

References to SciGraph publications

  • 1990. Channel Catfish Farming Handbook in NONE
  • 2012-01. HDAC inhibitors in parasitic diseases in IMMUNOLOGY AND CELL BIOLOGY
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    http://scigraph.springernature.com/pub.10.1007/s00580-019-02903-4

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    http://dx.doi.org/10.1007/s00580-019-02903-4

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