A comparative study of the long-term effects of piroxicam and ketoprofen on the gastric mucosa, kidney, liver, and hematopoietic system ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-02

AUTHORS

Javad Khoshnegah, Alireza Kamrani, Mehrdad Mohri

ABSTRACT

The use of non-steroidal anti-inflammatory drugs (NSAIDs) can be associated with severe adverse effects. The aim of this experimental study was to investigate the effect of piroxicam and ketoprofen, two NSAIDs with different excretion pathways, on the gastric mucosa, kidney, liver, and hematopoietic system of dogs. Fifteen mixed-breed healthy dogs of both sexes aged between 1 to 8 years were randomly divided in three groups and treated with piroxicam (0.15 mg/kg intramuscularly (IM)), ketoprofen (1 mg/kg IM) or placebo daily for 21 days. Although not statistically significant (p > 0.05), the dogs receiving ketoprofen showed fewer and less severe lesions than the dogs in the piroxicam group. None of the dogs showed any clinical signs related to the gastric lesions. Serum biochemical and complete blood count parameters did not change significantly after NSAlD administration (p > 0.05). However, by day 14, a decreased number of platelets and prolonged bleeding time were detected in treatment groups compared with the control group (p < 0.05). The clinical significance of this prolongation is unclear. This study suggests that ketoprofen and piroxicam produce mild lesions when administered to healthy dogs for 21 days, and there is no difference between the two groups in the number and severity of lesions. There may be an indication that longer duration of drug administration may result in a greater number of gastric lesions. However, after long-term NSAID exposure (21 days in our study), gastric tolerance to the damage caused by NSAIDs will be developed. More... »

PAGES

65-68

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00580-009-0934-4

DOI

http://dx.doi.org/10.1007/s00580-009-0934-4

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1027442892


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Ferdowsi University of Mashhad", 
          "id": "https://www.grid.ac/institutes/grid.411301.6", 
          "name": [
            "Department of Clinical Sciences, School of Veterinary Medicine, Ferdowsi University of Mashhad, P.O. Box\u00a091775-1793, Mashhad, Iran"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Khoshnegah", 
        "givenName": "Javad", 
        "id": "sg:person.01234311547.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234311547.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ferdowsi University of Mashhad", 
          "id": "https://www.grid.ac/institutes/grid.411301.6", 
          "name": [
            "Department of Clinical Sciences, School of Veterinary Medicine, Ferdowsi University of Mashhad, P.O. Box\u00a091775-1793, Mashhad, Iran"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kamrani", 
        "givenName": "Alireza", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ferdowsi University of Mashhad", 
          "id": "https://www.grid.ac/institutes/grid.411301.6", 
          "name": [
            "Department of Clinical Sciences, School of Veterinary Medicine, Ferdowsi University of Mashhad, P.O. Box\u00a091775-1793, Mashhad, Iran"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mohri", 
        "givenName": "Mehrdad", 
        "id": "sg:person.0777565175.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777565175.04"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1080/00480169.1996.35968", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012222830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf03220020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014831169", 
          "https://doi.org/10.1007/bf03220020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf01073339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015083606", 
          "https://doi.org/10.1007/bf01073339"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0195-5616(90)50036-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015533055"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1089-3261(05)70026-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019226364"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1748-5827.1998.tb03748.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021033289"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1552-4604.1988.tb05971.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028343662"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/newbio231232a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034018058", 
          "https://doi.org/10.1038/newbio231232a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/newbio231232a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034018058", 
          "https://doi.org/10.1038/newbio231232a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/newbio231232a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034018058", 
          "https://doi.org/10.1038/newbio231232a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archinte.1987.00370010087021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042822502"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0016-5085(88)90487-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047797065"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00544088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049763813", 
          "https://doi.org/10.1007/bf00544088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00544088", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049763813", 
          "https://doi.org/10.1007/bf00544088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199106133242407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051989414"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/archinte.147.1.85", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054111411"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpgi.2000.278.6.g839", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074655636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076266312", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078763678", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079785748", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079926594", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082803035", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2011-02", 
    "datePublishedReg": "2011-02-01", 
    "description": "The use of non-steroidal anti-inflammatory drugs (NSAIDs) can be associated with severe adverse effects. The aim of this experimental study was to investigate the effect of piroxicam and ketoprofen, two NSAIDs with different excretion pathways, on the gastric mucosa, kidney, liver, and hematopoietic system of dogs. Fifteen mixed-breed healthy dogs of both sexes aged between 1 to 8 years were randomly divided in three groups and treated with piroxicam (0.15 mg/kg intramuscularly (IM)), ketoprofen (1 mg/kg IM) or placebo daily for 21 days. Although not statistically significant (p > 0.05), the dogs receiving ketoprofen showed fewer and less severe lesions than the dogs in the piroxicam group. None of the dogs showed any clinical signs related to the gastric lesions. Serum biochemical and complete blood count parameters did not change significantly after NSAlD administration (p > 0.05). However, by day 14, a decreased number of platelets and prolonged bleeding time were detected in treatment groups compared with the control group (p < 0.05). The clinical significance of this prolongation is unclear. This study suggests that ketoprofen and piroxicam produce mild lesions when administered to healthy dogs for 21 days, and there is no difference between the two groups in the number and severity of lesions. There may be an indication that longer duration of drug administration may result in a greater number of gastric lesions. However, after long-term NSAID exposure (21 days in our study), gastric tolerance to the damage caused by NSAIDs will be developed.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s00580-009-0934-4", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1297472", 
        "issn": [
          "0938-7714", 
          "1433-2973"
        ], 
        "name": "Comparative Clinical Pathology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "20"
      }
    ], 
    "name": "A comparative study of the long-term effects of piroxicam and ketoprofen on the gastric mucosa, kidney, liver, and hematopoietic system of dogs", 
    "pagination": "65-68", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "82ba6a651f8816f3f990be8a64a4cdc62adc9557e1b1533cb169eec9362661fb"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00580-009-0934-4"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1027442892"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00580-009-0934-4", 
      "https://app.dimensions.ai/details/publication/pub.1027442892"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13068_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s00580-009-0934-4"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00580-009-0934-4'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00580-009-0934-4'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00580-009-0934-4'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00580-009-0934-4'


 

This table displays all metadata directly associated to this object as RDF triples.

130 TRIPLES      21 PREDICATES      46 URIs      19 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00580-009-0934-4 schema:about anzsrc-for:11
2 anzsrc-for:1103
3 schema:author N5d9ec86366c647f7ab95b49892ce6b2e
4 schema:citation sg:pub.10.1007/bf00544088
5 sg:pub.10.1007/bf01073339
6 sg:pub.10.1007/bf03220020
7 sg:pub.10.1038/newbio231232a0
8 https://app.dimensions.ai/details/publication/pub.1076266312
9 https://app.dimensions.ai/details/publication/pub.1078763678
10 https://app.dimensions.ai/details/publication/pub.1079785748
11 https://app.dimensions.ai/details/publication/pub.1079926594
12 https://app.dimensions.ai/details/publication/pub.1082803035
13 https://doi.org/10.1001/archinte.147.1.85
14 https://doi.org/10.1001/archinte.1987.00370010087021
15 https://doi.org/10.1002/j.1552-4604.1988.tb05971.x
16 https://doi.org/10.1016/0016-5085(88)90487-8
17 https://doi.org/10.1016/s0195-5616(90)50036-4
18 https://doi.org/10.1016/s1089-3261(05)70026-x
19 https://doi.org/10.1056/nejm199106133242407
20 https://doi.org/10.1080/00480169.1996.35968
21 https://doi.org/10.1111/j.1748-5827.1998.tb03748.x
22 https://doi.org/10.1152/ajpgi.2000.278.6.g839
23 schema:datePublished 2011-02
24 schema:datePublishedReg 2011-02-01
25 schema:description The use of non-steroidal anti-inflammatory drugs (NSAIDs) can be associated with severe adverse effects. The aim of this experimental study was to investigate the effect of piroxicam and ketoprofen, two NSAIDs with different excretion pathways, on the gastric mucosa, kidney, liver, and hematopoietic system of dogs. Fifteen mixed-breed healthy dogs of both sexes aged between 1 to 8 years were randomly divided in three groups and treated with piroxicam (0.15 mg/kg intramuscularly (IM)), ketoprofen (1 mg/kg IM) or placebo daily for 21 days. Although not statistically significant (p > 0.05), the dogs receiving ketoprofen showed fewer and less severe lesions than the dogs in the piroxicam group. None of the dogs showed any clinical signs related to the gastric lesions. Serum biochemical and complete blood count parameters did not change significantly after NSAlD administration (p > 0.05). However, by day 14, a decreased number of platelets and prolonged bleeding time were detected in treatment groups compared with the control group (p < 0.05). The clinical significance of this prolongation is unclear. This study suggests that ketoprofen and piroxicam produce mild lesions when administered to healthy dogs for 21 days, and there is no difference between the two groups in the number and severity of lesions. There may be an indication that longer duration of drug administration may result in a greater number of gastric lesions. However, after long-term NSAID exposure (21 days in our study), gastric tolerance to the damage caused by NSAIDs will be developed.
26 schema:genre research_article
27 schema:inLanguage en
28 schema:isAccessibleForFree false
29 schema:isPartOf N6376005eb8644b93b58a21d37531f64a
30 Nf70ba4c90e8544048ad2ff6da2a6ad94
31 sg:journal.1297472
32 schema:name A comparative study of the long-term effects of piroxicam and ketoprofen on the gastric mucosa, kidney, liver, and hematopoietic system of dogs
33 schema:pagination 65-68
34 schema:productId N490b874510bf4a2eb3047fbcd68643ed
35 N51fd8da8936c457291ce0dcdf6382fcc
36 N688d5bb37fc14dce84a3581e329d8aee
37 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027442892
38 https://doi.org/10.1007/s00580-009-0934-4
39 schema:sdDatePublished 2019-04-11T14:25
40 schema:sdLicense https://scigraph.springernature.com/explorer/license/
41 schema:sdPublisher N62d98acdf5a04f0c93ea8762e648413a
42 schema:url http://link.springer.com/10.1007/s00580-009-0934-4
43 sgo:license sg:explorer/license/
44 sgo:sdDataset articles
45 rdf:type schema:ScholarlyArticle
46 N3ea9804ca37142e79179b427a7ad31fb rdf:first N6a833a1da20d49fd87c0de1d9d5e9819
47 rdf:rest Nc6b8ec8ec2bd4e7088b692fe6bd03719
48 N490b874510bf4a2eb3047fbcd68643ed schema:name doi
49 schema:value 10.1007/s00580-009-0934-4
50 rdf:type schema:PropertyValue
51 N51fd8da8936c457291ce0dcdf6382fcc schema:name readcube_id
52 schema:value 82ba6a651f8816f3f990be8a64a4cdc62adc9557e1b1533cb169eec9362661fb
53 rdf:type schema:PropertyValue
54 N5d9ec86366c647f7ab95b49892ce6b2e rdf:first sg:person.01234311547.39
55 rdf:rest N3ea9804ca37142e79179b427a7ad31fb
56 N62d98acdf5a04f0c93ea8762e648413a schema:name Springer Nature - SN SciGraph project
57 rdf:type schema:Organization
58 N6376005eb8644b93b58a21d37531f64a schema:volumeNumber 20
59 rdf:type schema:PublicationVolume
60 N688d5bb37fc14dce84a3581e329d8aee schema:name dimensions_id
61 schema:value pub.1027442892
62 rdf:type schema:PropertyValue
63 N6a833a1da20d49fd87c0de1d9d5e9819 schema:affiliation https://www.grid.ac/institutes/grid.411301.6
64 schema:familyName Kamrani
65 schema:givenName Alireza
66 rdf:type schema:Person
67 Nc6b8ec8ec2bd4e7088b692fe6bd03719 rdf:first sg:person.0777565175.04
68 rdf:rest rdf:nil
69 Nf70ba4c90e8544048ad2ff6da2a6ad94 schema:issueNumber 1
70 rdf:type schema:PublicationIssue
71 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
72 schema:name Medical and Health Sciences
73 rdf:type schema:DefinedTerm
74 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
75 schema:name Clinical Sciences
76 rdf:type schema:DefinedTerm
77 sg:journal.1297472 schema:issn 0938-7714
78 1433-2973
79 schema:name Comparative Clinical Pathology
80 rdf:type schema:Periodical
81 sg:person.01234311547.39 schema:affiliation https://www.grid.ac/institutes/grid.411301.6
82 schema:familyName Khoshnegah
83 schema:givenName Javad
84 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234311547.39
85 rdf:type schema:Person
86 sg:person.0777565175.04 schema:affiliation https://www.grid.ac/institutes/grid.411301.6
87 schema:familyName Mohri
88 schema:givenName Mehrdad
89 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0777565175.04
90 rdf:type schema:Person
91 sg:pub.10.1007/bf00544088 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049763813
92 https://doi.org/10.1007/bf00544088
93 rdf:type schema:CreativeWork
94 sg:pub.10.1007/bf01073339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015083606
95 https://doi.org/10.1007/bf01073339
96 rdf:type schema:CreativeWork
97 sg:pub.10.1007/bf03220020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014831169
98 https://doi.org/10.1007/bf03220020
99 rdf:type schema:CreativeWork
100 sg:pub.10.1038/newbio231232a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034018058
101 https://doi.org/10.1038/newbio231232a0
102 rdf:type schema:CreativeWork
103 https://app.dimensions.ai/details/publication/pub.1076266312 schema:CreativeWork
104 https://app.dimensions.ai/details/publication/pub.1078763678 schema:CreativeWork
105 https://app.dimensions.ai/details/publication/pub.1079785748 schema:CreativeWork
106 https://app.dimensions.ai/details/publication/pub.1079926594 schema:CreativeWork
107 https://app.dimensions.ai/details/publication/pub.1082803035 schema:CreativeWork
108 https://doi.org/10.1001/archinte.147.1.85 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054111411
109 rdf:type schema:CreativeWork
110 https://doi.org/10.1001/archinte.1987.00370010087021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042822502
111 rdf:type schema:CreativeWork
112 https://doi.org/10.1002/j.1552-4604.1988.tb05971.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028343662
113 rdf:type schema:CreativeWork
114 https://doi.org/10.1016/0016-5085(88)90487-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047797065
115 rdf:type schema:CreativeWork
116 https://doi.org/10.1016/s0195-5616(90)50036-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015533055
117 rdf:type schema:CreativeWork
118 https://doi.org/10.1016/s1089-3261(05)70026-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1019226364
119 rdf:type schema:CreativeWork
120 https://doi.org/10.1056/nejm199106133242407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051989414
121 rdf:type schema:CreativeWork
122 https://doi.org/10.1080/00480169.1996.35968 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012222830
123 rdf:type schema:CreativeWork
124 https://doi.org/10.1111/j.1748-5827.1998.tb03748.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021033289
125 rdf:type schema:CreativeWork
126 https://doi.org/10.1152/ajpgi.2000.278.6.g839 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074655636
127 rdf:type schema:CreativeWork
128 https://www.grid.ac/institutes/grid.411301.6 schema:alternateName Ferdowsi University of Mashhad
129 schema:name Department of Clinical Sciences, School of Veterinary Medicine, Ferdowsi University of Mashhad, P.O. Box 91775-1793, Mashhad, Iran
130 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...