Do local anesthetics interact preferentially with membrane lipid rafts? Comparative interactivities with raft-like membranes View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-08

AUTHORS

Hironori Tsuchiya, Takahiro Ueno, Maki Mizogami, Ko Takakura

ABSTRACT

Membranous lipid bilayers have been reconsidered as the site of action of local anesthetics (LAs). Recent understanding of biomembranes indicates the existence of lipid raft microdomains enriched in cholesterol and sphingolipids as potential platforms for channels and receptors. Based on the hypothesis that LAs may interact preferentially with lipid rafts over non-raft membranes, we compared their effects on raft model membranes and cardiolipin-containing biomimetic membranes. Liposomes were prepared with phospholipids, sphingomyelin, cerebroside, and cholesterol to have compositions corresponding to lipid rafts and cardiomyocyte mitochondrial membranes. After reacting LAs (50-200 microM) with the membrane preparations, their interactivities were determined by measuring fluorescence polarization with 1,6-diphenyl-1,3,5-hexatriene. Although bupivacaine and lidocaine acted on different raft-like liquid-ordered membranes to reduce polarization values, their effects on biomimetic less ordered membranes were much greater. LAs interacted with biomimetic membranes with the potency being R(+)-bupivacaine > racemic bupivacaine > S(-)-bupivacaine > ropivacaine > lidocaine > prilocaine, which is consistent with the rank order of pharmacotoxicological potency. However, raft model membranes showed neither structure-dependence nor stereoselectivity. The relevance of membrane lipid rafts to LAs is questionable at least in their effects on raft-like liquid-ordered membranes. More... »

PAGES

639-642

References to SciGraph publications

  • 2000-10. Lipid rafts and signal transduction in NATURE REVIEWS MOLECULAR CELL BIOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00540-010-0943-0

    DOI

    http://dx.doi.org/10.1007/s00540-010-0943-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1027734638

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20414686


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biochemistry and Cell Biology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Biological Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Anesthetics, Local", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cardiolipins", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Membrane Lipids", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Membrane Microdomains", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Asahi University", 
              "id": "https://www.grid.ac/institutes/grid.411456.3", 
              "name": [
                "Department of Dental Basic Education, Building 3, Asahi University School of Dentistry, 1851-1 Hozumi, 501-0296, Mizuho, Gifu, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tsuchiya", 
            "givenName": "Hironori", 
            "id": "sg:person.0700223345.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700223345.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Asahi University", 
              "id": "https://www.grid.ac/institutes/grid.411456.3", 
              "name": [
                "Department of Anesthesiology, Asahi University School of Dentistry, 1851-1 Hozumi, 501-0296, Mizuho, Gifu, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ueno", 
            "givenName": "Takahiro", 
            "id": "sg:person.01061167215.91", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061167215.91"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Asahi University", 
              "id": "https://www.grid.ac/institutes/grid.411456.3", 
              "name": [
                "Department of Anesthesiology, Asahi University School of Dentistry, 1851-1 Hozumi, 501-0296, Mizuho, Gifu, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mizogami", 
            "givenName": "Maki", 
            "id": "sg:person.01014451745.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014451745.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Asahi University", 
              "id": "https://www.grid.ac/institutes/grid.411456.3", 
              "name": [
                "Department of Anesthesiology, Asahi University School of Dentistry, 1851-1 Hozumi, 501-0296, Mizuho, Gifu, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takakura", 
            "givenName": "Ko", 
            "id": "sg:person.0713470710.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713470710.76"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "https://doi.org/10.1016/j.cbi.2009.10.006", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003012200"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35036052", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004200173", 
              "https://doi.org/10.1038/35036052"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35036052", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004200173", 
              "https://doi.org/10.1038/35036052"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/35036052", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004200173", 
              "https://doi.org/10.1038/35036052"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.91.25.12130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006516027"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000539-200101000-00008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010012473"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/00000539-200101000-00008", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010012473"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.tcm.2003.10.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010678013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.abb.2004.10.025", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016603078"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/ajh.21126", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018874505"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2147/lra.s3876", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018977800"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.ics.2005.06.077", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019802158"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj2710269", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023046487"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj2710269", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023046487"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-3495(95)79920-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023618496"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1074/jbc.m201644200", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025496652"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bja/ael079", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033127298"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-3495(01)76114-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033613402"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.cbi.2007.06.002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039340259"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1213/ane.0b013e3181706c7e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046435719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1213/ane.0b013e3181706c7e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046435719"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0006-3495(02)75501-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051783940"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/rapm.2002.36458", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052915755"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2010-08", 
        "datePublishedReg": "2010-08-01", 
        "description": "Membranous lipid bilayers have been reconsidered as the site of action of local anesthetics (LAs). Recent understanding of biomembranes indicates the existence of lipid raft microdomains enriched in cholesterol and sphingolipids as potential platforms for channels and receptors. Based on the hypothesis that LAs may interact preferentially with lipid rafts over non-raft membranes, we compared their effects on raft model membranes and cardiolipin-containing biomimetic membranes. Liposomes were prepared with phospholipids, sphingomyelin, cerebroside, and cholesterol to have compositions corresponding to lipid rafts and cardiomyocyte mitochondrial membranes. After reacting LAs (50-200 microM) with the membrane preparations, their interactivities were determined by measuring fluorescence polarization with 1,6-diphenyl-1,3,5-hexatriene. Although bupivacaine and lidocaine acted on different raft-like liquid-ordered membranes to reduce polarization values, their effects on biomimetic less ordered membranes were much greater. LAs interacted with biomimetic membranes with the potency being R(+)-bupivacaine > racemic bupivacaine > S(-)-bupivacaine > ropivacaine > lidocaine > prilocaine, which is consistent with the rank order of pharmacotoxicological potency. However, raft model membranes showed neither structure-dependence nor stereoselectivity. The relevance of membrane lipid rafts to LAs is questionable at least in their effects on raft-like liquid-ordered membranes.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00540-010-0943-0", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.6001824", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1099224", 
            "issn": [
              "0913-8668", 
              "1438-8359"
            ], 
            "name": "Journal of Anesthesia", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "24"
          }
        ], 
        "name": "Do local anesthetics interact preferentially with membrane lipid rafts? Comparative interactivities with raft-like membranes", 
        "pagination": "639-642", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "841efd199383925d8fb966b20a4a3cf45a783de5feeeac3d1f03793aeda69f4b"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "20414686"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8905667"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00540-010-0943-0"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1027734638"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00540-010-0943-0", 
          "https://app.dimensions.ai/details/publication/pub.1027734638"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T10:28", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113640_00000001.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs00540-010-0943-0"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00540-010-0943-0'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00540-010-0943-0'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00540-010-0943-0'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00540-010-0943-0'


     

    This table displays all metadata directly associated to this object as RDF triples.

    164 TRIPLES      21 PREDICATES      51 URIs      25 LITERALS      13 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00540-010-0943-0 schema:about N08b7abec223d4e68a4f58e7493d234d6
    2 N23f17a1635ce44febf13a3a635112b2c
    3 N323641335bf84cd2a8e8ad9f35a2b704
    4 N62fec6f2c52a4dcbb9b9c7b3b47f834f
    5 anzsrc-for:06
    6 anzsrc-for:0601
    7 schema:author Ne656b556ad0e4b5282b2260b59068180
    8 schema:citation sg:pub.10.1038/35036052
    9 https://doi.org/10.1002/ajh.21126
    10 https://doi.org/10.1016/j.abb.2004.10.025
    11 https://doi.org/10.1016/j.cbi.2007.06.002
    12 https://doi.org/10.1016/j.cbi.2009.10.006
    13 https://doi.org/10.1016/j.ics.2005.06.077
    14 https://doi.org/10.1016/j.tcm.2003.10.002
    15 https://doi.org/10.1016/s0006-3495(01)76114-0
    16 https://doi.org/10.1016/s0006-3495(02)75501-x
    17 https://doi.org/10.1016/s0006-3495(95)79920-9
    18 https://doi.org/10.1042/bj2710269
    19 https://doi.org/10.1053/rapm.2002.36458
    20 https://doi.org/10.1073/pnas.91.25.12130
    21 https://doi.org/10.1074/jbc.m201644200
    22 https://doi.org/10.1093/bja/ael079
    23 https://doi.org/10.1097/00000539-200101000-00008
    24 https://doi.org/10.1213/ane.0b013e3181706c7e
    25 https://doi.org/10.2147/lra.s3876
    26 schema:datePublished 2010-08
    27 schema:datePublishedReg 2010-08-01
    28 schema:description Membranous lipid bilayers have been reconsidered as the site of action of local anesthetics (LAs). Recent understanding of biomembranes indicates the existence of lipid raft microdomains enriched in cholesterol and sphingolipids as potential platforms for channels and receptors. Based on the hypothesis that LAs may interact preferentially with lipid rafts over non-raft membranes, we compared their effects on raft model membranes and cardiolipin-containing biomimetic membranes. Liposomes were prepared with phospholipids, sphingomyelin, cerebroside, and cholesterol to have compositions corresponding to lipid rafts and cardiomyocyte mitochondrial membranes. After reacting LAs (50-200 microM) with the membrane preparations, their interactivities were determined by measuring fluorescence polarization with 1,6-diphenyl-1,3,5-hexatriene. Although bupivacaine and lidocaine acted on different raft-like liquid-ordered membranes to reduce polarization values, their effects on biomimetic less ordered membranes were much greater. LAs interacted with biomimetic membranes with the potency being R(+)-bupivacaine > racemic bupivacaine > S(-)-bupivacaine > ropivacaine > lidocaine > prilocaine, which is consistent with the rank order of pharmacotoxicological potency. However, raft model membranes showed neither structure-dependence nor stereoselectivity. The relevance of membrane lipid rafts to LAs is questionable at least in their effects on raft-like liquid-ordered membranes.
    29 schema:genre research_article
    30 schema:inLanguage en
    31 schema:isAccessibleForFree false
    32 schema:isPartOf N6ec5391cdfd54b1eb69b85d015b1dd9a
    33 N7a6f98978726414393c16a4306d28e31
    34 sg:journal.1099224
    35 schema:name Do local anesthetics interact preferentially with membrane lipid rafts? Comparative interactivities with raft-like membranes
    36 schema:pagination 639-642
    37 schema:productId N331660aeb29d4e878911b95debfe6180
    38 N7219ca39c7604e1182f46e6d43148ecb
    39 N749e3bf116014dd4a712174a0642d22a
    40 N928f24fc4e4448dcb2ce71316e8f04a3
    41 Nced40c8563574c2c8c80ed95d9a5f1d1
    42 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027734638
    43 https://doi.org/10.1007/s00540-010-0943-0
    44 schema:sdDatePublished 2019-04-11T10:28
    45 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    46 schema:sdPublisher N750654f973ca45028afef01f1955b4cc
    47 schema:url http://link.springer.com/10.1007%2Fs00540-010-0943-0
    48 sgo:license sg:explorer/license/
    49 sgo:sdDataset articles
    50 rdf:type schema:ScholarlyArticle
    51 N08b7abec223d4e68a4f58e7493d234d6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    52 schema:name Membrane Microdomains
    53 rdf:type schema:DefinedTerm
    54 N23283efdd6fc448a982b3f28e9bcb6ea rdf:first sg:person.0713470710.76
    55 rdf:rest rdf:nil
    56 N23f17a1635ce44febf13a3a635112b2c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    57 schema:name Cardiolipins
    58 rdf:type schema:DefinedTerm
    59 N323641335bf84cd2a8e8ad9f35a2b704 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    60 schema:name Anesthetics, Local
    61 rdf:type schema:DefinedTerm
    62 N331660aeb29d4e878911b95debfe6180 schema:name doi
    63 schema:value 10.1007/s00540-010-0943-0
    64 rdf:type schema:PropertyValue
    65 N62fec6f2c52a4dcbb9b9c7b3b47f834f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    66 schema:name Membrane Lipids
    67 rdf:type schema:DefinedTerm
    68 N635f5eac7b76435997177675db6f9ff9 rdf:first sg:person.01014451745.01
    69 rdf:rest N23283efdd6fc448a982b3f28e9bcb6ea
    70 N65198559189f40ef8de5614eb8c6dbc7 rdf:first sg:person.01061167215.91
    71 rdf:rest N635f5eac7b76435997177675db6f9ff9
    72 N6ec5391cdfd54b1eb69b85d015b1dd9a schema:issueNumber 4
    73 rdf:type schema:PublicationIssue
    74 N7219ca39c7604e1182f46e6d43148ecb schema:name readcube_id
    75 schema:value 841efd199383925d8fb966b20a4a3cf45a783de5feeeac3d1f03793aeda69f4b
    76 rdf:type schema:PropertyValue
    77 N749e3bf116014dd4a712174a0642d22a schema:name pubmed_id
    78 schema:value 20414686
    79 rdf:type schema:PropertyValue
    80 N750654f973ca45028afef01f1955b4cc schema:name Springer Nature - SN SciGraph project
    81 rdf:type schema:Organization
    82 N7a6f98978726414393c16a4306d28e31 schema:volumeNumber 24
    83 rdf:type schema:PublicationVolume
    84 N928f24fc4e4448dcb2ce71316e8f04a3 schema:name dimensions_id
    85 schema:value pub.1027734638
    86 rdf:type schema:PropertyValue
    87 Nced40c8563574c2c8c80ed95d9a5f1d1 schema:name nlm_unique_id
    88 schema:value 8905667
    89 rdf:type schema:PropertyValue
    90 Ne656b556ad0e4b5282b2260b59068180 rdf:first sg:person.0700223345.59
    91 rdf:rest N65198559189f40ef8de5614eb8c6dbc7
    92 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
    93 schema:name Biological Sciences
    94 rdf:type schema:DefinedTerm
    95 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
    96 schema:name Biochemistry and Cell Biology
    97 rdf:type schema:DefinedTerm
    98 sg:grant.6001824 http://pending.schema.org/fundedItem sg:pub.10.1007/s00540-010-0943-0
    99 rdf:type schema:MonetaryGrant
    100 sg:journal.1099224 schema:issn 0913-8668
    101 1438-8359
    102 schema:name Journal of Anesthesia
    103 rdf:type schema:Periodical
    104 sg:person.01014451745.01 schema:affiliation https://www.grid.ac/institutes/grid.411456.3
    105 schema:familyName Mizogami
    106 schema:givenName Maki
    107 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01014451745.01
    108 rdf:type schema:Person
    109 sg:person.01061167215.91 schema:affiliation https://www.grid.ac/institutes/grid.411456.3
    110 schema:familyName Ueno
    111 schema:givenName Takahiro
    112 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061167215.91
    113 rdf:type schema:Person
    114 sg:person.0700223345.59 schema:affiliation https://www.grid.ac/institutes/grid.411456.3
    115 schema:familyName Tsuchiya
    116 schema:givenName Hironori
    117 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0700223345.59
    118 rdf:type schema:Person
    119 sg:person.0713470710.76 schema:affiliation https://www.grid.ac/institutes/grid.411456.3
    120 schema:familyName Takakura
    121 schema:givenName Ko
    122 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713470710.76
    123 rdf:type schema:Person
    124 sg:pub.10.1038/35036052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004200173
    125 https://doi.org/10.1038/35036052
    126 rdf:type schema:CreativeWork
    127 https://doi.org/10.1002/ajh.21126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018874505
    128 rdf:type schema:CreativeWork
    129 https://doi.org/10.1016/j.abb.2004.10.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016603078
    130 rdf:type schema:CreativeWork
    131 https://doi.org/10.1016/j.cbi.2007.06.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039340259
    132 rdf:type schema:CreativeWork
    133 https://doi.org/10.1016/j.cbi.2009.10.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003012200
    134 rdf:type schema:CreativeWork
    135 https://doi.org/10.1016/j.ics.2005.06.077 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019802158
    136 rdf:type schema:CreativeWork
    137 https://doi.org/10.1016/j.tcm.2003.10.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010678013
    138 rdf:type schema:CreativeWork
    139 https://doi.org/10.1016/s0006-3495(01)76114-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033613402
    140 rdf:type schema:CreativeWork
    141 https://doi.org/10.1016/s0006-3495(02)75501-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051783940
    142 rdf:type schema:CreativeWork
    143 https://doi.org/10.1016/s0006-3495(95)79920-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023618496
    144 rdf:type schema:CreativeWork
    145 https://doi.org/10.1042/bj2710269 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023046487
    146 rdf:type schema:CreativeWork
    147 https://doi.org/10.1053/rapm.2002.36458 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052915755
    148 rdf:type schema:CreativeWork
    149 https://doi.org/10.1073/pnas.91.25.12130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006516027
    150 rdf:type schema:CreativeWork
    151 https://doi.org/10.1074/jbc.m201644200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025496652
    152 rdf:type schema:CreativeWork
    153 https://doi.org/10.1093/bja/ael079 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033127298
    154 rdf:type schema:CreativeWork
    155 https://doi.org/10.1097/00000539-200101000-00008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010012473
    156 rdf:type schema:CreativeWork
    157 https://doi.org/10.1213/ane.0b013e3181706c7e schema:sameAs https://app.dimensions.ai/details/publication/pub.1046435719
    158 rdf:type schema:CreativeWork
    159 https://doi.org/10.2147/lra.s3876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018977800
    160 rdf:type schema:CreativeWork
    161 https://www.grid.ac/institutes/grid.411456.3 schema:alternateName Asahi University
    162 schema:name Department of Anesthesiology, Asahi University School of Dentistry, 1851-1 Hozumi, 501-0296, Mizuho, Gifu, Japan
    163 Department of Dental Basic Education, Building 3, Asahi University School of Dentistry, 1851-1 Hozumi, 501-0296, Mizuho, Gifu, Japan
    164 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...