The expression of matrix metalloproteinase matrilysin indicates the degree of inflammation in ulcerative colitis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2003-04

AUTHORS

Keiki Matsuno, Yasushi Adachi, Hiroyuki Yamamoto, Akira Goto, Yoshiaki Arimura, Takao Endo, Fumio Itoh, Kohzoh Imai

ABSTRACT

Background: Any alteration in the synthesis and breakdown of the extracellular matrix is important in tissue remodeling during inflammation and wound healing. The degradation of the extracellular matrix components is regulated by a cascade of matrix metalloproteinases (MMPs). The present study attempted to assess the relationship between MMPs and the degree of inflammation in ulcerative colitis. Methods: The expression of MMPs, including MMP-1, -2, -3, -7 (matrilysin), and -9, and that of their inhibitors (tissue inhibitor of metalloproteinases [TIMP]-1 and -2) were analyzed immunohistochemically by using 52 formalin-fixed and paraffin-embedded specimens from patients with ulcerative colitis who had undergone a biopsy or surgery. Results: It was observed that MMP-1, -2, and -9, and the TIMPs were expressed in stromal cells, MMP-3 was expressed in both the epithelial cells and stromal components, and matrilysin was expressed only in the epithelial cells on the edge of ulcers. The expression of the MMPs was increased compared with that of the TIMPs. The frequency of matrilysin expression was increased corresponding to the severity of the inflammation. Matrilysin was also expressed in epithelial cells with dysplasia and cancer. Conclusions: Matrilysin expression could be an important marker of activity and could be used for the prediction of subsequent transformation in patients with ulcerative colitis. More... »

PAGES

348-354

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s005350300062

DOI

http://dx.doi.org/10.1007/s005350300062

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018578241

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/12743774


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