Peptic ulcer recurrence during maintenance therapy with H2-receptor antagonist following first-line therapy with proton pump inhibitor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2000-11

AUTHORS

Eizo Kaneko, Yoshio Hoshihara, Nobuhiro Sakaki, Shigeru Harasawa, Kiyoshi Ashida, Masahiro Asaka, Shigeru Asaki, Takashi Nakamura, Kenzo Kobayashi, Goro Kajiyama, Nobuya Ogawa, Tsuneyoshi Yao, Yasutoshi Muto, Saburo Nakazawa, Tadayoshi Takemoto

ABSTRACT

: We investigated the peptic ulcer recurrence rates during maintenance therapy with H2-receptor antagonists (H2RAs) following first-line therapy with a proton pump inhibitor (PPI). Patients with gastric ulcer (GU) or duodenal ulcer (DU) were enrolled in this study; 583 eligible patients (GU, 325; DU, 258) were administered lansoprazole (30 mg/day for 8 weeks for GU, and the same dosage for 6 weeks for DU) as first-line therapy, and a half dose of H2RA as maintenance therapy for 12 months. Endoscopic photographs were taken before administration and after 8 (GU) and 6 (DU) weeks of lansoprazole administration. Ulcer stage was evaluated using the classification of Sakita and Miwa. Endoscopic examinations were performed 6 months or 12 months after the start of maintenance therapy or when a recurrence was suspected because of the appearance of subjective symptoms. The healing rates for GU and DU patients after completion of lansoprazole therapy were 79% in both groups, while the S2-stage healing rates were 18% and 31%, respectively. At 1 year after the start of maintenance therapy, the recurrence rates were 25% for GU and 39% for DU patients. In DU patients, the recurrence rates from S1-stage and S2-stage were 49% and 20%, respectively (P = 0.004), but no significant difference was found between these rates in GU patients. The recurrence rates in H. pylori-positive patients before lansoprazole administration were 27% for GU and 43% for DU patients. We concluded that the maintenance therapy with a half-dose of H2RA following PPI therapy was insufficient to prevent recurrences of GU and DU. More... »

PAGES

824-831

Journal

TITLE

Journal of Gastroenterology

ISSUE

11

VOLUME

35

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s005350070019

DOI

http://dx.doi.org/10.1007/s005350070019

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014275477

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/11085491


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