Esophageal carcinoma with high serum parathyroid hormone-related protein (PTHrP) level View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

1999-07

AUTHORS

Hiroyuki A. Watanabe, Hiroshi Matsushita, Hideo Matsui, Tsutomu Komatsu, Susumu Taguchi, Hiroshi Sata, Nagahisa Amano

ABSTRACT

We report two patients with esophageal carcinoma with high levels of serum parathyroid hormone-related protein (PTHrP). Patient 1 was a 66-year-old man in whom the serum calcium level was also high, and patient 2 was an 81-year-old woman. The serum PTHrP level was 411 pM (normal range, 13.8-55.3pM) in patient 1 and 94.5 pM in patient 2 (in whom the serum granulocyte colony-stimulating factor level was also high). We demonstrated PTHrP immunohistologically in esophageal carcinoma cells in both patients. After admission, patient 1 died of pneumonia on the 17th day of hospitalization (the 48th day after he had had an episode of frequent hiccuping) and patient 2 died of acute circulatory failure on the 12th day of hospitalization (the 25th day after she had vomited after a meal). Neither of these patients died of cancer. Pneumonia in patient 1 was believed to be due to weakened body defenses, while the acute circulatory failure in patient 2 was due to emaciation. Since esophageal carcinoma with humoral hypercalcemia of malignancy and leukocytosis is characterized by rapid progression and metastasis, early diagnosis and treatment are mandatory. More... »

PAGES

510-515

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s005350050305

DOI

http://dx.doi.org/10.1007/s005350050305

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047071744

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/10452686


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