Clinicopathological and molecular characterization of early gastric adenocarcinoma in Helicobacter pylori-uninfected patients: emphasis on differentiated gastric adenocarcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2022-08-08

AUTHORS

Yoichi Akazawa, Hiroya Ueyama, Takuo Hayashi, Hisanori Utsunomiya, Ryota Uchida, Daiki Abe, Shotaro Oki, Nobuyuki Suzuki, Atsushi Ikeda, Noboru Yatagai, Hiroyuki Komori, Tsutomu Takeda, Kohei Matsumoto, Kumiko Ueda, Kenshi Matsumoto, Daisuke Asaoka, Mariko Hojo, Tsuyoshi Saito, Takashi Yao, Akihito Nagahara

ABSTRACT

BackgroundRecently, Helicobacter pylori (HP)-uninfected gastric mucosal cancer has been reported; however, the clinicopathological and molecular features of HP-uninfected gastric cancer have not been elucidated.MethodsWe evaluated the clinicopathological, immunohistochemical, and genetic alterations in HP-uninfected early gastric adenocarcinoma using next-generation sequencing (NGS).ResultsAmong 968 primary early gastric carcinomas, 64 (6.6%) were HP-uninfected gastric adenocarcinoma and were pathologically classified as gastric adenocarcinoma of fundic-gland type (GA-FG, n = 39), differentiated gastric adenocarcinoma (DGA, n = 16), and signet-ring cell carcinoma (SRCC, n = 9). Based on the expression profile of the mucin core protein, DGAs were classified into a gastrointestinal phenotype showing either MUC5AC or MUC6 expression and MUC2 or CD10 expression simultaneously (n = 5), and a gastric phenotype (n = 11) showing either MUC5AC or MUC6 expression. All DGAs with a gastrointestinal phenotype shared similar endoscopic characteristics, such as reddish depressed lesions in the antrum. In contrast, DGAs with a gastric phenotype exhibited several distinct endoscopic features, including a raspberry-shaped appearance and whitish flat-elevated appearance; the former expressed only MUC5AC and the latter exhibited co-expression of MUC5AC and MUC6. Among 16 HP-uninfected DGAs, seven were subjected to NGS. APC was recurrently mutated in DGA (42.9%) and was enriched in DGAs with a gastrointestinal phenotype (75%).ConclusionsOverall, HP-uninfected gastric adenocarcinomas showed distinct clinicopathologic and endoscopic characteristics. Furthermore, HP-uninfected DGAs, especially those with a gastrointestinal phenotype, may be characterized by recurrent APC mutations. More... »

PAGES

725-734

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00535-022-01906-3

    DOI

    http://dx.doi.org/10.1007/s00535-022-01906-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1150069955

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35939123


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