Mortality and cancer in eosinophilic gastrointestinal disorders distal to the esophagus: nationwide cohort study 1990–2017 View Full Text


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Article Info

DATE

2022-07-19

AUTHORS

Adam C. Bledsoe, John J. Garber, Weimin Ye, Bjorn Roelstraete, Joseph A. Murray, Jonas F. Ludvigsson

ABSTRACT

BackgroundEosinophilic gastrointestinal disorders (EGIDs) include inflammatory conditions with enteric infiltration of eosinophils and resulting symptoms. This study aims to examine a population-based sample of patients for prevalence, mortality, and cancer risk in EGIDs distal to the esophagus.MethodsNationwide, population-based cohort study. EGID was identified through relevant biopsy codes from Sweden’s all 28 pathology departments through the ESPRESSO cohort. Individuals with EGID were then matched to general population reference individuals with similar age and sex. Study participants were linked to Swedish healthcare registers. Through Cox regression, we calculated adjusted hazard ratios (aHRs) adjusting for sex, age, county, calendar period, and education.ResultsIn total, 2429 patients (56% female) were found to have EGID distal to the esophagus, representing a prevalence of about 1/4800 in the Swedish population. Mean age was 44 years with 11% children at the time of diagnosis. Mortality was increased 17% in patients with EGIDs compared to reference individuals (aHR = 1.17; 95%CI = 1.04–1.33). Excess mortality was seen in gastric and small bowel eosinophilic disease, but not colonic disease (aHR = 1.81; 95%CI = 1.32–2.48, aHR = 1.50; 95%CI = 1.18–1.89, and aHR = 0.99; 95%CI = 0.85–1.16, respectively). Cause specific mortality was driven by cancer-related death (aHR = 1.33; 95%CI = 1.05–1.69). However, this study failed to show an increase in incident cancers (aHR = 1.14; 95%CI = 0.96–1.35). Comparison of EGID individuals with their siblings yielded similar aHRs.ConclusionsThis study found an increased risk of death in patients with EGIDs distal to the esophagus, with cancer death driving the increase. Proximal gut disease seems to confer the greatest risk. There was no increase in incident cancers. More... »

PAGES

735-747

References to SciGraph publications

  • 2017-09. The Swedish cause of death register in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 2016-01-14. Registers of the Swedish total population and their use in medical research in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 2019-03-30. The longitudinal integrated database for health insurance and labour market studies (LISA) and its use in medical research in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 2015-08-02. Eosinophilic Esophagitis and Gastroenteritis in CURRENT ALLERGY AND ASTHMA REPORTS
  • 2019-03-22. Eosinophilic Gastrointestinal Disorders in CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00535-022-01904-5

    DOI

    http://dx.doi.org/10.1007/s00535-022-01904-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1149590638

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35852631


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