The personality traits activity, self-reproach, and negative affect jointly predict clinical recurrence, depressive symptoms, and low quality of life in ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-07-28

AUTHORS

Sebastian Bruno Ulrich Jordi, Brian Matthew Lang, Jacqueline Wyss, Bianca Auschra, Bahtiyar Yilmaz, Niklas Krupka, Thomas Greuter, Philipp Schreiner, Luc Biedermann, Martin Preisig, Roland von Känel, Gerhard Rogler, Stefan Begré, Benjamin Misselwitz

ABSTRACT

BackgroundThe bidirectional “gut-brain axis” has been implicated in the pathogenesis of inflammatory bowel diseases (IBD). While the influence of stress and depressive symptoms on IBD is well-characterized, the role of personality remains insufficiently investigated.MethodsPersonality was assessed in 1154 Swiss IBD cohort study (SIBDCS) patients via the NEO-Five-Factor Inventory (NEO-FFI) as well as in 2600 participants of the population-based CoLaus¦PsyCoLaus cohort study (NEO-FFI-revised). The NEO-FFI subcomponents activity, self-reproach and negative affect were associated with higher IBD disease activity and were combined to a NEO-FFI risk score. This risk score was validated and its effect on clinical IBD course and psychological endpoints was analysed in time-to-event and cumulative incidence analyses.ResultsIn time-to-event analyses, a high NEO-FFI risk score was predictive for the clinical endpoints of new extraintestinal manifestation [EIM, adjusted hazard ratio (aHR) = 1.64, corrected p value (q) = 0.036] and two established composite flare endpoints (aHR = 1.53–1.63, q = 0.003–0.006) as well as for the psychological endpoints depressive symptoms (aHR = 7.06, q < 0.001) and low quality of life (aHR = 3.06, q < 0.001). Furthermore, cumulative incidence analyses showed that patients at high NEO-FFI risk experienced significantly more episodes of active disease, new EIMs, one of the flare endpoints, depressive episodes and low disease-related quality of life. Personalities of IBD patients showed only minor differences from the general population sample (Pearson’s r = 0.03–0.14).ConclusionsPersonality assessed by the NEO-FFI contained considerable predictive power for disease recurrence, depressive symptoms and low quality of life in IBD patients. Nevertheless, the personalities of IBD patients did not substantially differ from the general population. More... »

PAGES

848-866

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00535-022-01902-7

DOI

http://dx.doi.org/10.1007/s00535-022-01902-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1149820319

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/35900592


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18 schema:description BackgroundThe bidirectional “gut-brain axis” has been implicated in the pathogenesis of inflammatory bowel diseases (IBD). While the influence of stress and depressive symptoms on IBD is well-characterized, the role of personality remains insufficiently investigated.MethodsPersonality was assessed in 1154 Swiss IBD cohort study (SIBDCS) patients via the NEO-Five-Factor Inventory (NEO-FFI) as well as in 2600 participants of the population-based CoLaus¦PsyCoLaus cohort study (NEO-FFI-revised). The NEO-FFI subcomponents activity, self-reproach and negative affect were associated with higher IBD disease activity and were combined to a NEO-FFI risk score. This risk score was validated and its effect on clinical IBD course and psychological endpoints was analysed in time-to-event and cumulative incidence analyses.ResultsIn time-to-event analyses, a high NEO-FFI risk score was predictive for the clinical endpoints of new extraintestinal manifestation [EIM, adjusted hazard ratio (aHR) = 1.64, corrected p value (q) = 0.036] and two established composite flare endpoints (aHR = 1.53–1.63, q = 0.003–0.006) as well as for the psychological endpoints depressive symptoms (aHR = 7.06, q < 0.001) and low quality of life (aHR = 3.06, q < 0.001). Furthermore, cumulative incidence analyses showed that patients at high NEO-FFI risk experienced significantly more episodes of active disease, new EIMs, one of the flare endpoints, depressive episodes and low disease-related quality of life. Personalities of IBD patients showed only minor differences from the general population sample (Pearson’s r = 0.03–0.14).ConclusionsPersonality assessed by the NEO-FFI contained considerable predictive power for disease recurrence, depressive symptoms and low quality of life in IBD patients. Nevertheless, the personalities of IBD patients did not substantially differ from the general population.
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24 schema:keywords CoLaus
25 EIM
26 IBD course
27 IBD disease activity
28 IBD patients
29 Inventory
30 NEO-Five Factor Inventory
31 active disease
32 activity
33 affect
34 analysis
35 axis
36 bowel disease
37 bowel disease patients
38 clinical endpoints
39 clinical recurrence
40 cohort study
41 considerable predictive power
42 course
43 cumulative incidence analysis
44 depressive episode
45 depressive symptoms
46 differences
47 disease
48 disease activity
49 disease patients
50 disease recurrence
51 disease-related quality
52 effect
53 endpoint
54 episodes
55 event analysis
56 events
57 extraintestinal manifestations
58 general population
59 general population sample
60 gut-brain axis
61 incidence analysis
62 inflammatory bowel disease
63 inflammatory bowel disease patients
64 influence
65 influence of stress
66 life
67 low quality
68 manifestations
69 minor differences
70 more episodes
71 negative affect
72 participants
73 pathogenesis
74 patients
75 personality
76 population
77 population sample
78 power
79 predictive power
80 psychological endpoints
81 quality
82 recurrence
83 risk
84 risk score
85 role
86 role of personality
87 samples
88 scores
89 stress
90 study
91 study patients
92 symptoms
93 time
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