Evidence-based clinical practice guidelines for functional dyspepsia 2021 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2022-01-21

AUTHORS

Hiroto Miwa, Akihito Nagahara, Akihiro Asakawa, Makoto Arai, Tadayuki Oshima, Kunio Kasugai, Kazuhiro Kamada, Hidekazu Suzuki, Fumio Tanaka, Kazunari Tominaga, Seiji Futagami, Mariko Hojo, Hiroshi Mihara, Kazuhide Higuchi, Motoyasu Kusano, Tomiyasu Arisawa, Mototsugu Kato, Takashi Joh, Satoshi Mochida, Nobuyuki Enomoto, Tooru Shimosegawa, Kazuhiko Koike

ABSTRACT

BackgroundFunctional dyspepsia (FD) is a disorder that presents with chronic dyspepsia, which is not only very common but also highly affects quality of life of the patients. In Japan, FD became a disease name for national insurance in 2013, and has been gradually recognized, though still not satisfactory. Following the revision policy of Japanese Society of Gastroenterology (JSGE), the first version of FD guideline was revised this time. MethodLike previously, the guideline was created by the GRADE (grading of recommendations assessment, development and evaluation) system, but this time, the questions were classified to background questions (BQs, 24 already clarified issues), future research questions (FRQs, 9 issues cannot be addressed with insufficient evidence), and 7 clinical questions that are mainly associated with treatment.Results and ConclusionThese revised guidelines have two major features. The first is the new position of endoscopy in the flow of FD diagnosis. While endoscopy was required to all cases for diagnosis of FD, the revised guidelines specify the necessity of endoscopy only in cases where organic disease is suspected. The second feature is that the drug treatment options have been changed to reflect the latest evidence. The first-line treatment includes gastric acid-secretion inhibitors, acetylcholinesterase (AChE) inhibitors (acotiamide, a prokinetic agent), and Japanese herbal medicine (rikkunshito). The second-line treatment includes anxiolytics /antidepressant, prokinetics other than acotiamide (dopamine receptor antagonists, 5-HT4 receptor agonists), and Japanese herbal medicines other than rikkunshito. The patients not responding to these treatment regimens are regarded as refractory FD. More... »

PAGES

47-61

References to SciGraph publications

  • 2018-11-01. Gastroparesis in NATURE REVIEWS DISEASE PRIMERS
  • 2013-03-16. Kampo medicines for gastrointestinal tract disorders: a review of basic science and clinical evidence and their future application in JOURNAL OF GASTROENTEROLOGY
  • 2012-04-03. Effect of Dyspepsia on Survival: A Longitudinal 10-Year Follow-Up Study in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2010-02-16. Impact of Functional Gastrointestinal Disorders on Survival in the Community in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2012-05-23. Genetic polymorphisms of SCN10A are associated with functional dyspepsia in Japanese subjects in JOURNAL OF GASTROENTEROLOGY
  • 2017-06-20. ACG and CAG Clinical Guideline: Management of Dyspepsia in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2009-07-28. Efficacy of the 5-HT1A Agonist Tandospirone Citrate in Improving Symptoms of Patients With Functional Dyspepsia: A Randomized Controlled Trial in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2008-06. Tegaserod Treatment for Dysmotility-Like Functional Dyspepsia: Results of Two Randomized, Controlled Trials in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2016-12-13. Pathophysiological Abnormalities in Functional Dyspepsia Subgroups According to the Rome III Criteria in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2008-09-04. Functional Dyspepsia Is Associated With a Greater Symptomatic Response to Fat But Not Carbohydrate, Increased Fasting and Postprandial CCK, and Diminished PYY in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2010-05-11. Migration of Eosinophils and CCR2-/CD68-Double Positive Cells Into the Duodenal Mucosa of Patients With Postinfectious Functional Dyspepsia in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2014-11-22. Childhood abuse history is associated with the development of dyspepsia: a population-based survey in Japan in JOURNAL OF GASTROENTEROLOGY
  • 2008-02-01. Endoscopy in GERD: Boondoggle, Diagnostic Test, or Risk Management Tool? in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 1998-09. Disturbed Solid-Phase Gastric Emptying in Functional Dyspepsia (A Meta-Analysis) in DIGESTIVE DISEASES AND SCIENCES
  • 2019-02-14. Recent understanding of the pathophysiology of functional dyspepsia: role of the duodenum as the pathogenic center in JOURNAL OF GASTROENTEROLOGY
  • 2015-01-14. Evidence-based clinical practice guidelines for functional dyspepsia in JOURNAL OF GASTROENTEROLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00535-021-01843-7

    DOI

    http://dx.doi.org/10.1007/s00535-021-01843-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1144860420

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/35061057


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Acetylcholinesterase", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Dyspepsia", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Endoscopy, Gastrointestinal", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Gastroenterology", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Helicobacter Infections", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Quality of Life", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663-8501, Nishinomiya, Hyogo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.272264.7", 
              "name": [
                "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan", 
                "Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663-8501, Nishinomiya, Hyogo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Miwa", 
            "givenName": "Hiroto", 
            "id": "sg:person.0611747536.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611747536.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nagahara", 
            "givenName": "Akihito", 
            "id": "sg:person.01205010513.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205010513.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Asakawa", 
            "givenName": "Akihiro", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Arai", 
            "givenName": "Makoto", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Oshima", 
            "givenName": "Tadayuki", 
            "id": "sg:person.0723101126.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723101126.27"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kasugai", 
            "givenName": "Kunio", 
            "id": "sg:person.0620576202.05", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620576202.05"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kamada", 
            "givenName": "Kazuhiro", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Suzuki", 
            "givenName": "Hidekazu", 
            "id": "sg:person.016300210764.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016300210764.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tanaka", 
            "givenName": "Fumio", 
            "id": "sg:person.01051425642.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051425642.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tominaga", 
            "givenName": "Kazunari", 
            "id": "sg:person.011011100722.83", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011011100722.83"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Futagami", 
            "givenName": "Seiji", 
            "id": "sg:person.0636322323.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636322323.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hojo", 
            "givenName": "Mariko", 
            "id": "sg:person.01163062712.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163062712.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mihara", 
            "givenName": "Hiroshi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Higuchi", 
            "givenName": "Kazuhide", 
            "id": "sg:person.01075057036.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075057036.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kusano", 
            "givenName": "Motoyasu", 
            "id": "sg:person.0756476660.86", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756476660.86"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Arisawa", 
            "givenName": "Tomiyasu", 
            "id": "sg:person.01103357131.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103357131.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kato", 
            "givenName": "Mototsugu", 
            "id": "sg:person.013105652032.69", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013105652032.69"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Joh", 
            "givenName": "Takashi", 
            "id": "sg:person.01124072460.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124072460.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mochida", 
            "givenName": "Satoshi", 
            "id": "sg:person.01224266362.61", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224266362.61"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Enomoto", 
            "givenName": "Nobuyuki", 
            "id": "sg:person.01353463070.60", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353463070.60"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shimosegawa", 
            "givenName": "Tooru", 
            "id": "sg:person.01255535707.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255535707.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Guidelines Committee for Creating and Evaluating the \u201cEvidence-Based Clinical Practice Guidelines for Functional Dyspepsia\u201d, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Koike", 
            "givenName": "Kazuhiko", 
            "id": "sg:person.01231713652.67", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231713652.67"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1111/j.1572-0241.2008.02041.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049594304", 
              "https://doi.org/10.1111/j.1572-0241.2008.02041.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2012.69", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004992746", 
              "https://doi.org/10.1038/ajg.2012.69"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00535-012-0602-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012084621", 
              "https://doi.org/10.1007/s00535-012-0602-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1572-0241.2008.01953.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010241202", 
              "https://doi.org/10.1111/j.1572-0241.2008.01953.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2016.499", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041343093", 
              "https://doi.org/10.1038/ajg.2016.499"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2017.154", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086078080", 
              "https://doi.org/10.1038/ajg.2017.154"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1111/j.1572-0241.2007.01654.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051108808", 
              "https://doi.org/10.1111/j.1572-0241.2007.01654.x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2009.427", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002339417", 
              "https://doi.org/10.1038/ajg.2009.427"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00535-019-01550-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1112140060", 
              "https://doi.org/10.1007/s00535-019-01550-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/s41572-018-0038-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1107948164", 
              "https://doi.org/10.1038/s41572-018-0038-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00535-014-1022-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010859527", 
              "https://doi.org/10.1007/s00535-014-1022-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1018803129779", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036356763", 
              "https://doi.org/10.1023/a:1018803129779"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00535-013-0788-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1006344830", 
              "https://doi.org/10.1007/s00535-013-0788-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2010.151", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005787538", 
              "https://doi.org/10.1038/ajg.2010.151"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2010.40", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040917921", 
              "https://doi.org/10.1038/ajg.2010.40"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00535-014-1014-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052324804", 
              "https://doi.org/10.1007/s00535-014-1014-3"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2022-01-21", 
        "datePublishedReg": "2022-01-21", 
        "description": "BackgroundFunctional dyspepsia (FD) is a disorder that presents with chronic dyspepsia, which is not only very common but also highly affects quality of life of the patients. In Japan, FD became a disease name for national insurance in 2013, and has been gradually recognized, though still not satisfactory. Following the revision policy of Japanese Society of Gastroenterology (JSGE), the first version of FD guideline was revised this time. MethodLike previously, the guideline was created by the GRADE (grading of recommendations assessment, development and evaluation) system, but this time, the questions were classified to background questions (BQs, 24 already clarified issues), future research questions (FRQs, 9 issues cannot be addressed with insufficient evidence), and 7 clinical questions that are mainly associated with treatment.Results and ConclusionThese revised guidelines have two major features. The first is the new position of endoscopy in the flow of FD diagnosis. While endoscopy was required to all cases for diagnosis of FD, the revised guidelines specify the necessity of endoscopy only in cases where organic disease is suspected. The second feature is that the drug treatment options have been changed to reflect the latest evidence. The first-line treatment includes gastric acid-secretion inhibitors, acetylcholinesterase (AChE) inhibitors (acotiamide, a prokinetic agent), and Japanese herbal medicine (rikkunshito). The second-line treatment includes anxiolytics /antidepressant, prokinetics other than acotiamide (dopamine receptor antagonists, 5-HT4 receptor agonists), and Japanese herbal medicines other than rikkunshito. The patients not responding to these treatment regimens are regarded as refractory FD.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00535-021-01843-7", 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1009747", 
            "issn": [
              "0944-1174", 
              "1435-5922"
            ], 
            "name": "Journal of Gastroenterology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "57"
          }
        ], 
        "keywords": [
          "Japanese herbal medicine", 
          "evidence-based clinical practice guidelines", 
          "herbal medicine", 
          "gastric acid secretion inhibitors", 
          "necessity of endoscopy", 
          "second-line treatment", 
          "first-line treatment", 
          "clinical practice guidelines", 
          "drug treatment options", 
          "diagnosis of FD", 
          "acid secretion inhibitors", 
          "quality of life", 
          "refractory FD", 
          "chronic dyspepsia", 
          "treatment regimens", 
          "FD diagnosis", 
          "treatment options", 
          "organic disease", 
          "practice guidelines", 
          "clinical questions", 
          "BackgroundFunctional dyspepsia", 
          "latest evidence", 
          "GRADE system", 
          "endoscopy", 
          "dyspepsia", 
          "patients", 
          "treatment", 
          "diagnosis", 
          "guidelines", 
          "national insurance", 
          "inhibitors", 
          "Japanese Society", 
          "medicine", 
          "prokinetics", 
          "rikkunshito", 
          "regimens", 
          "acotiamide", 
          "anxiolytics", 
          "gastroenterology", 
          "disease names", 
          "disease", 
          "disorders", 
          "ConclusionThese", 
          "cases", 
          "options", 
          "future research questions", 
          "evidence", 
          "insurance", 
          "major features", 
          "life", 
          "time", 
          "features", 
          "questions", 
          "FD", 
          "quality", 
          "Japan", 
          "research questions", 
          "results", 
          "necessity", 
          "new position", 
          "society", 
          "version", 
          "flow", 
          "system", 
          "position", 
          "first version", 
          "policy", 
          "name", 
          "second feature", 
          "revision policy"
        ], 
        "name": "Evidence-based clinical practice guidelines for functional dyspepsia 2021", 
        "pagination": "47-61", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1144860420"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00535-021-01843-7"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "35061057"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00535-021-01843-7", 
          "https://app.dimensions.ai/details/publication/pub.1144860420"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-08-04T17:10", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_929.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00535-021-01843-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00535-021-01843-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00535-021-01843-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00535-021-01843-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00535-021-01843-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    370 TRIPLES      21 PREDICATES      118 URIs      94 LITERALS      14 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00535-021-01843-7 schema:about N11f13701ed834375ade970b663d6b0e6
    2 N53ba690a2d0144ac992c70d30e29bbb4
    3 Na6aea9f4482143eca204eda78fe0854b
    4 Nc104a5726150477a841f30120acfc191
    5 Ncfe12bb30c8943b1b6a6c4ebe9f07f7e
    6 Ndc86616b5eda43559391122644edbef7
    7 Nf0c2a7eedab540bd80be42595bf62364
    8 anzsrc-for:11
    9 anzsrc-for:1103
    10 schema:author N9bceb202b1924ad192fbd06eada9500a
    11 schema:citation sg:pub.10.1007/s00535-012-0602-3
    12 sg:pub.10.1007/s00535-013-0788-z
    13 sg:pub.10.1007/s00535-014-1014-3
    14 sg:pub.10.1007/s00535-014-1022-3
    15 sg:pub.10.1007/s00535-019-01550-4
    16 sg:pub.10.1023/a:1018803129779
    17 sg:pub.10.1038/ajg.2009.427
    18 sg:pub.10.1038/ajg.2010.151
    19 sg:pub.10.1038/ajg.2010.40
    20 sg:pub.10.1038/ajg.2012.69
    21 sg:pub.10.1038/ajg.2016.499
    22 sg:pub.10.1038/ajg.2017.154
    23 sg:pub.10.1038/s41572-018-0038-z
    24 sg:pub.10.1111/j.1572-0241.2007.01654.x
    25 sg:pub.10.1111/j.1572-0241.2008.01953.x
    26 sg:pub.10.1111/j.1572-0241.2008.02041.x
    27 schema:datePublished 2022-01-21
    28 schema:datePublishedReg 2022-01-21
    29 schema:description BackgroundFunctional dyspepsia (FD) is a disorder that presents with chronic dyspepsia, which is not only very common but also highly affects quality of life of the patients. In Japan, FD became a disease name for national insurance in 2013, and has been gradually recognized, though still not satisfactory. Following the revision policy of Japanese Society of Gastroenterology (JSGE), the first version of FD guideline was revised this time. MethodLike previously, the guideline was created by the GRADE (grading of recommendations assessment, development and evaluation) system, but this time, the questions were classified to background questions (BQs, 24 already clarified issues), future research questions (FRQs, 9 issues cannot be addressed with insufficient evidence), and 7 clinical questions that are mainly associated with treatment.Results and ConclusionThese revised guidelines have two major features. The first is the new position of endoscopy in the flow of FD diagnosis. While endoscopy was required to all cases for diagnosis of FD, the revised guidelines specify the necessity of endoscopy only in cases where organic disease is suspected. The second feature is that the drug treatment options have been changed to reflect the latest evidence. The first-line treatment includes gastric acid-secretion inhibitors, acetylcholinesterase (AChE) inhibitors (acotiamide, a prokinetic agent), and Japanese herbal medicine (rikkunshito). The second-line treatment includes anxiolytics /antidepressant, prokinetics other than acotiamide (dopamine receptor antagonists, 5-HT4 receptor agonists), and Japanese herbal medicines other than rikkunshito. The patients not responding to these treatment regimens are regarded as refractory FD.
    30 schema:genre article
    31 schema:isAccessibleForFree true
    32 schema:isPartOf Nc223be18f9d44a5eb73c4b6beebac9b6
    33 Nfc8b5814e2a84b26aa5f232b9bac772a
    34 sg:journal.1009747
    35 schema:keywords BackgroundFunctional dyspepsia
    36 ConclusionThese
    37 FD
    38 FD diagnosis
    39 GRADE system
    40 Japan
    41 Japanese Society
    42 Japanese herbal medicine
    43 acid secretion inhibitors
    44 acotiamide
    45 anxiolytics
    46 cases
    47 chronic dyspepsia
    48 clinical practice guidelines
    49 clinical questions
    50 diagnosis
    51 diagnosis of FD
    52 disease
    53 disease names
    54 disorders
    55 drug treatment options
    56 dyspepsia
    57 endoscopy
    58 evidence
    59 evidence-based clinical practice guidelines
    60 features
    61 first version
    62 first-line treatment
    63 flow
    64 future research questions
    65 gastric acid secretion inhibitors
    66 gastroenterology
    67 guidelines
    68 herbal medicine
    69 inhibitors
    70 insurance
    71 latest evidence
    72 life
    73 major features
    74 medicine
    75 name
    76 national insurance
    77 necessity
    78 necessity of endoscopy
    79 new position
    80 options
    81 organic disease
    82 patients
    83 policy
    84 position
    85 practice guidelines
    86 prokinetics
    87 quality
    88 quality of life
    89 questions
    90 refractory FD
    91 regimens
    92 research questions
    93 results
    94 revision policy
    95 rikkunshito
    96 second feature
    97 second-line treatment
    98 society
    99 system
    100 time
    101 treatment
    102 treatment options
    103 treatment regimens
    104 version
    105 schema:name Evidence-based clinical practice guidelines for functional dyspepsia 2021
    106 schema:pagination 47-61
    107 schema:productId N701f95ee379441ae80fc8ba4a519eb17
    108 Nae0a4c7ebf55420c9c240ccac126be2d
    109 Nda751c856cc84381b4492d867168392c
    110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1144860420
    111 https://doi.org/10.1007/s00535-021-01843-7
    112 schema:sdDatePublished 2022-08-04T17:10
    113 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    114 schema:sdPublisher Naa32506bb3a345b8a6c44c57e90df98a
    115 schema:url https://doi.org/10.1007/s00535-021-01843-7
    116 sgo:license sg:explorer/license/
    117 sgo:sdDataset articles
    118 rdf:type schema:ScholarlyArticle
    119 N0cca81872f794f7ab45e3a4284935113 rdf:first sg:person.013105652032.69
    120 rdf:rest Ncfe00013a527473b851ddca4dc43ee56
    121 N11f13701ed834375ade970b663d6b0e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    122 schema:name Quality of Life
    123 rdf:type schema:DefinedTerm
    124 N125a96708d6440df87cb8ffb4c849b5d rdf:first sg:person.0723101126.27
    125 rdf:rest Ncbc7ee51ef5c4cfab73744d52de566ce
    126 N3204088ab00e46ff997ed869a59813c1 rdf:first sg:person.0636322323.29
    127 rdf:rest N72dc5b8c9c77469eae44df8acdf99b2b
    128 N3e8f4d002c164bff8eae6041c1ea14e8 rdf:first sg:person.01353463070.60
    129 rdf:rest N5fb5615cbe4840ef9222408f5bb91f74
    130 N4ed2c4c936824452b39a5aaf21f64417 rdf:first Nb23a1c86e08941db87b5a5da1901caab
    131 rdf:rest Ndcaa8e06468c4a52b0ea1bf66a9a2197
    132 N53ba690a2d0144ac992c70d30e29bbb4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    133 schema:name Helicobacter Infections
    134 rdf:type schema:DefinedTerm
    135 N5b6fb4f8a30341afab17947eb9ac1e09 schema:affiliation grid-institutes:None
    136 schema:familyName Arai
    137 schema:givenName Makoto
    138 rdf:type schema:Person
    139 N5fb5615cbe4840ef9222408f5bb91f74 rdf:first sg:person.01255535707.76
    140 rdf:rest Nd425cd16c0354c0f90cbb5f20cbaca0e
    141 N648f0ce8a982400d8b97e91c08c5d448 rdf:first sg:person.016300210764.14
    142 rdf:rest Nf12d061889ba47139f9af1ae429a6d29
    143 N701f95ee379441ae80fc8ba4a519eb17 schema:name pubmed_id
    144 schema:value 35061057
    145 rdf:type schema:PropertyValue
    146 N72dc5b8c9c77469eae44df8acdf99b2b rdf:first sg:person.01163062712.31
    147 rdf:rest Na41eb5e7905a4c6e881af74167571e3f
    148 N7641a61690054ea49d62ce2fd83458be rdf:first Nd67044018ea94975b9e78fccf39fd201
    149 rdf:rest N648f0ce8a982400d8b97e91c08c5d448
    150 N9b409b3ed3184de0abb689ae771ace6e rdf:first sg:person.01224266362.61
    151 rdf:rest N3e8f4d002c164bff8eae6041c1ea14e8
    152 N9bceb202b1924ad192fbd06eada9500a rdf:first sg:person.0611747536.16
    153 rdf:rest Nb6bd97c36fd14c9da2a3c6288e662c69
    154 Na41eb5e7905a4c6e881af74167571e3f rdf:first Ne4125bb436bf49919a794cdce605ddad
    155 rdf:rest Na7181c1281894e4c97794ea45a926185
    156 Na6aea9f4482143eca204eda78fe0854b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Gastroenterology
    158 rdf:type schema:DefinedTerm
    159 Na7181c1281894e4c97794ea45a926185 rdf:first sg:person.01075057036.16
    160 rdf:rest Nb6fe3dee550141d5ba9423e0eb8a0f4c
    161 Naa32506bb3a345b8a6c44c57e90df98a schema:name Springer Nature - SN SciGraph project
    162 rdf:type schema:Organization
    163 Nae0a4c7ebf55420c9c240ccac126be2d schema:name doi
    164 schema:value 10.1007/s00535-021-01843-7
    165 rdf:type schema:PropertyValue
    166 Nb23a1c86e08941db87b5a5da1901caab schema:affiliation grid-institutes:None
    167 schema:familyName Asakawa
    168 schema:givenName Akihiro
    169 rdf:type schema:Person
    170 Nb55e231502574178b709bc742fd89aa4 rdf:first sg:person.01103357131.16
    171 rdf:rest N0cca81872f794f7ab45e3a4284935113
    172 Nb6bd97c36fd14c9da2a3c6288e662c69 rdf:first sg:person.01205010513.10
    173 rdf:rest N4ed2c4c936824452b39a5aaf21f64417
    174 Nb6fe3dee550141d5ba9423e0eb8a0f4c rdf:first sg:person.0756476660.86
    175 rdf:rest Nb55e231502574178b709bc742fd89aa4
    176 Nc104a5726150477a841f30120acfc191 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    177 schema:name Acetylcholinesterase
    178 rdf:type schema:DefinedTerm
    179 Nc223be18f9d44a5eb73c4b6beebac9b6 schema:issueNumber 2
    180 rdf:type schema:PublicationIssue
    181 Ncbc7ee51ef5c4cfab73744d52de566ce rdf:first sg:person.0620576202.05
    182 rdf:rest N7641a61690054ea49d62ce2fd83458be
    183 Ncfe00013a527473b851ddca4dc43ee56 rdf:first sg:person.01124072460.75
    184 rdf:rest N9b409b3ed3184de0abb689ae771ace6e
    185 Ncfe12bb30c8943b1b6a6c4ebe9f07f7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    186 schema:name Humans
    187 rdf:type schema:DefinedTerm
    188 Nd425cd16c0354c0f90cbb5f20cbaca0e rdf:first sg:person.01231713652.67
    189 rdf:rest rdf:nil
    190 Nd67044018ea94975b9e78fccf39fd201 schema:affiliation grid-institutes:None
    191 schema:familyName Kamada
    192 schema:givenName Kazuhiro
    193 rdf:type schema:Person
    194 Nda751c856cc84381b4492d867168392c schema:name dimensions_id
    195 schema:value pub.1144860420
    196 rdf:type schema:PropertyValue
    197 Ndc86616b5eda43559391122644edbef7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    198 schema:name Dyspepsia
    199 rdf:type schema:DefinedTerm
    200 Ndcaa8e06468c4a52b0ea1bf66a9a2197 rdf:first N5b6fb4f8a30341afab17947eb9ac1e09
    201 rdf:rest N125a96708d6440df87cb8ffb4c849b5d
    202 Ne4125bb436bf49919a794cdce605ddad schema:affiliation grid-institutes:None
    203 schema:familyName Mihara
    204 schema:givenName Hiroshi
    205 rdf:type schema:Person
    206 Nf0c2a7eedab540bd80be42595bf62364 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    207 schema:name Endoscopy, Gastrointestinal
    208 rdf:type schema:DefinedTerm
    209 Nf12d061889ba47139f9af1ae429a6d29 rdf:first sg:person.01051425642.79
    210 rdf:rest Nf5661b25b2c1484784bf3a734c7791fd
    211 Nf5661b25b2c1484784bf3a734c7791fd rdf:first sg:person.011011100722.83
    212 rdf:rest N3204088ab00e46ff997ed869a59813c1
    213 Nfc8b5814e2a84b26aa5f232b9bac772a schema:volumeNumber 57
    214 rdf:type schema:PublicationVolume
    215 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    216 schema:name Medical and Health Sciences
    217 rdf:type schema:DefinedTerm
    218 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    219 schema:name Clinical Sciences
    220 rdf:type schema:DefinedTerm
    221 sg:journal.1009747 schema:issn 0944-1174
    222 1435-5922
    223 schema:name Journal of Gastroenterology
    224 schema:publisher Springer Nature
    225 rdf:type schema:Periodical
    226 sg:person.01051425642.79 schema:affiliation grid-institutes:None
    227 schema:familyName Tanaka
    228 schema:givenName Fumio
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01051425642.79
    230 rdf:type schema:Person
    231 sg:person.01075057036.16 schema:affiliation grid-institutes:None
    232 schema:familyName Higuchi
    233 schema:givenName Kazuhide
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075057036.16
    235 rdf:type schema:Person
    236 sg:person.011011100722.83 schema:affiliation grid-institutes:None
    237 schema:familyName Tominaga
    238 schema:givenName Kazunari
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011011100722.83
    240 rdf:type schema:Person
    241 sg:person.01103357131.16 schema:affiliation grid-institutes:None
    242 schema:familyName Arisawa
    243 schema:givenName Tomiyasu
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103357131.16
    245 rdf:type schema:Person
    246 sg:person.01124072460.75 schema:affiliation grid-institutes:None
    247 schema:familyName Joh
    248 schema:givenName Takashi
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124072460.75
    250 rdf:type schema:Person
    251 sg:person.01163062712.31 schema:affiliation grid-institutes:None
    252 schema:familyName Hojo
    253 schema:givenName Mariko
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01163062712.31
    255 rdf:type schema:Person
    256 sg:person.01205010513.10 schema:affiliation grid-institutes:None
    257 schema:familyName Nagahara
    258 schema:givenName Akihito
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01205010513.10
    260 rdf:type schema:Person
    261 sg:person.01224266362.61 schema:affiliation grid-institutes:None
    262 schema:familyName Mochida
    263 schema:givenName Satoshi
    264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01224266362.61
    265 rdf:type schema:Person
    266 sg:person.01231713652.67 schema:affiliation grid-institutes:None
    267 schema:familyName Koike
    268 schema:givenName Kazuhiko
    269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231713652.67
    270 rdf:type schema:Person
    271 sg:person.01255535707.76 schema:affiliation grid-institutes:None
    272 schema:familyName Shimosegawa
    273 schema:givenName Tooru
    274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255535707.76
    275 rdf:type schema:Person
    276 sg:person.013105652032.69 schema:affiliation grid-institutes:None
    277 schema:familyName Kato
    278 schema:givenName Mototsugu
    279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013105652032.69
    280 rdf:type schema:Person
    281 sg:person.01353463070.60 schema:affiliation grid-institutes:None
    282 schema:familyName Enomoto
    283 schema:givenName Nobuyuki
    284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01353463070.60
    285 rdf:type schema:Person
    286 sg:person.016300210764.14 schema:affiliation grid-institutes:None
    287 schema:familyName Suzuki
    288 schema:givenName Hidekazu
    289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016300210764.14
    290 rdf:type schema:Person
    291 sg:person.0611747536.16 schema:affiliation grid-institutes:grid.272264.7
    292 schema:familyName Miwa
    293 schema:givenName Hiroto
    294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0611747536.16
    295 rdf:type schema:Person
    296 sg:person.0620576202.05 schema:affiliation grid-institutes:None
    297 schema:familyName Kasugai
    298 schema:givenName Kunio
    299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620576202.05
    300 rdf:type schema:Person
    301 sg:person.0636322323.29 schema:affiliation grid-institutes:None
    302 schema:familyName Futagami
    303 schema:givenName Seiji
    304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636322323.29
    305 rdf:type schema:Person
    306 sg:person.0723101126.27 schema:affiliation grid-institutes:None
    307 schema:familyName Oshima
    308 schema:givenName Tadayuki
    309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723101126.27
    310 rdf:type schema:Person
    311 sg:person.0756476660.86 schema:affiliation grid-institutes:None
    312 schema:familyName Kusano
    313 schema:givenName Motoyasu
    314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0756476660.86
    315 rdf:type schema:Person
    316 sg:pub.10.1007/s00535-012-0602-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012084621
    317 https://doi.org/10.1007/s00535-012-0602-3
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1007/s00535-013-0788-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1006344830
    320 https://doi.org/10.1007/s00535-013-0788-z
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1007/s00535-014-1014-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052324804
    323 https://doi.org/10.1007/s00535-014-1014-3
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1007/s00535-014-1022-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010859527
    326 https://doi.org/10.1007/s00535-014-1022-3
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1007/s00535-019-01550-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112140060
    329 https://doi.org/10.1007/s00535-019-01550-4
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1023/a:1018803129779 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036356763
    332 https://doi.org/10.1023/a:1018803129779
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1038/ajg.2009.427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002339417
    335 https://doi.org/10.1038/ajg.2009.427
    336 rdf:type schema:CreativeWork
    337 sg:pub.10.1038/ajg.2010.151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005787538
    338 https://doi.org/10.1038/ajg.2010.151
    339 rdf:type schema:CreativeWork
    340 sg:pub.10.1038/ajg.2010.40 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040917921
    341 https://doi.org/10.1038/ajg.2010.40
    342 rdf:type schema:CreativeWork
    343 sg:pub.10.1038/ajg.2012.69 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004992746
    344 https://doi.org/10.1038/ajg.2012.69
    345 rdf:type schema:CreativeWork
    346 sg:pub.10.1038/ajg.2016.499 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041343093
    347 https://doi.org/10.1038/ajg.2016.499
    348 rdf:type schema:CreativeWork
    349 sg:pub.10.1038/ajg.2017.154 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086078080
    350 https://doi.org/10.1038/ajg.2017.154
    351 rdf:type schema:CreativeWork
    352 sg:pub.10.1038/s41572-018-0038-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1107948164
    353 https://doi.org/10.1038/s41572-018-0038-z
    354 rdf:type schema:CreativeWork
    355 sg:pub.10.1111/j.1572-0241.2007.01654.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1051108808
    356 https://doi.org/10.1111/j.1572-0241.2007.01654.x
    357 rdf:type schema:CreativeWork
    358 sg:pub.10.1111/j.1572-0241.2008.01953.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1010241202
    359 https://doi.org/10.1111/j.1572-0241.2008.01953.x
    360 rdf:type schema:CreativeWork
    361 sg:pub.10.1111/j.1572-0241.2008.02041.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1049594304
    362 https://doi.org/10.1111/j.1572-0241.2008.02041.x
    363 rdf:type schema:CreativeWork
    364 grid-institutes:None schema:alternateName Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Functional Dyspepsia”, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan
    365 schema:name Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Functional Dyspepsia”, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan
    366 rdf:type schema:Organization
    367 grid-institutes:grid.272264.7 schema:alternateName Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663-8501, Nishinomiya, Hyogo, Japan
    368 schema:name Division of Gastroenterology and Hepatology, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, 663-8501, Nishinomiya, Hyogo, Japan
    369 Guidelines Committee for Creating and Evaluating the “Evidence-Based Clinical Practice Guidelines for Functional Dyspepsia”, The Japanese Society of Gastroenterology, 6F Shimbashi i-MARK Building, 2-6-2 Shimbashi, Minato-ku, 105-0004, Tokyo, Japan
    370 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...