Real world data of liver injury induced by immune checkpoint inhibitors in Japanese patients with advanced malignancies View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2020-03-02

AUTHORS

Kazuyuki Mizuno, Takanori Ito, Masatoshi Ishigami, Yoji Ishizu, Teiji Kuzuya, Takashi Honda, Hiroki Kawashima, Yosuke Inukai, Hidenori Toyoda, Kenji Yokota, Tetsunari Hase, Osamu Maeda, Hitoshi Kiyoi, Masato Nagino, Hideharu Hibi, Yasuhiro Kodera, Yasushi Fujimoto, Michihiko Sone, Momokazu Gotoh, Yuichi Ando, Masashi Akiyama, Yoshinori Hasegawa, Mitsuhiro Fujishiro

ABSTRACT

BackgroundLiver injury induced by immune checkpoint inhibitors (ICIs) is an immune-related adverse event (irAE) whose incidence has increased with the broader use of ICIs in clinical practice. However, the incidental risk factors of immune-related liver injury are unknown. We investigated the clinical characteristics of immune-related liver injury.MethodsA total of 546 patients treated with ICIs for advanced malignancies between September 2014 and February 2019 were included retrospectively. Factors associated with immune-related liver injury were determined.ResultsImmune-related liver injury (≥ Grade 3) occurred in 29 (5.3%) patients (Grade 3, n = 20; Grade 4, n = 8; Grade 5, n = 1) during the follow-up period (median 153 days). The patterns of liver injuries were hepatocellular, n = 6 (20.7%); cholestatic, n = 17 (58.6%); and mixed, n = 6 (20.7%). The median period between the initial administration of ICIs and the incidence of irAEs was 52 days. Of 29 patients with immune-related liver injury (≥ Grade 3), four showed immune-related cholangitis with non-obstructive dilation of the bile ducts. Factors that were significantly associated with the incidence of immune-related liver injury in multivariate analysis were use of ipilimumab, anti-cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) agent [hazard ratio [HR] 4.22, 95% confidence interval (CI) 1.65–10.80, P = 0.003], and fever over 38 °C within 24 h of initial ICI administration (HR 6.21, 95% CI 2.68–14.40, P < 0.001).ConclusionsWe found that the use of ipilimumab and the presence of fever within 24 h of initial ICI administration were predictive factors for immune-related liver injury. More... »

PAGES

653-661

Journal

TITLE

Journal of Gastroenterology

ISSUE

6

VOLUME

55

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00535-020-01677-9

DOI

http://dx.doi.org/10.1007/s00535-020-01677-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1125320472

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/32124082


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemical and Drug Induced Liver Injury", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fever", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Follow-Up Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immune Checkpoint Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Incidence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ipilimumab", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Japan", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Retrospective Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mizuno", 
        "givenName": "Kazuyuki", 
        "id": "sg:person.07374462067.98", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07374462067.98"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ito", 
        "givenName": "Takanori", 
        "id": "sg:person.0641441563.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641441563.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishigami", 
        "givenName": "Masatoshi", 
        "id": "sg:person.01062370120.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062370120.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishizu", 
        "givenName": "Yoji", 
        "id": "sg:person.0774403755.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774403755.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuzuya", 
        "givenName": "Teiji", 
        "id": "sg:person.0617426112.12", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617426112.12"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Honda", 
        "givenName": "Takashi", 
        "id": "sg:person.0732632701.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732632701.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Endoscopy, Nagoya University Hospital, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.437848.4", 
          "name": [
            "Department of Endoscopy, Nagoya University Hospital, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kawashima", 
        "givenName": "Hiroki", 
        "id": "sg:person.01273031773.59", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273031773.59"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology and Hepatology, Ogaki Municipal Hospital, Ogaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416762.0", 
          "name": [
            "Department of Gastroenterology and Hepatology, Ogaki Municipal Hospital, Ogaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Inukai", 
        "givenName": "Yosuke", 
        "id": "sg:person.010767423067.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010767423067.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology and Hepatology, Ogaki Municipal Hospital, Ogaki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.416762.0", 
          "name": [
            "Department of Gastroenterology and Hepatology, Ogaki Municipal Hospital, Ogaki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Toyoda", 
        "givenName": "Hidenori", 
        "id": "sg:person.01212503247.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212503247.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yokota", 
        "givenName": "Kenji", 
        "id": "sg:person.01255644630.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255644630.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hase", 
        "givenName": "Tetsunari", 
        "id": "sg:person.01166316575.80", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166316575.80"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.437848.4", 
          "name": [
            "Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maeda", 
        "givenName": "Osamu", 
        "id": "sg:person.01035104457.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035104457.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kiyoi", 
        "givenName": "Hitoshi", 
        "id": "sg:person.0577356402.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577356402.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nagino", 
        "givenName": "Masato", 
        "id": "sg:person.01211606464.55", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211606464.55"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hibi", 
        "givenName": "Hideharu", 
        "id": "sg:person.013004313704.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013004313704.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kodera", 
        "givenName": "Yasuhiro", 
        "id": "sg:person.01343614333.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343614333.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fujimoto", 
        "givenName": "Yasushi", 
        "id": "sg:person.0675666250.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675666250.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sone", 
        "givenName": "Michihiko", 
        "id": "sg:person.01147235443.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147235443.61"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gotoh", 
        "givenName": "Momokazu", 
        "id": "sg:person.012312611762.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012312611762.94"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.437848.4", 
          "name": [
            "Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ando", 
        "givenName": "Yuichi", 
        "id": "sg:person.013237674417.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013237674417.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Akiyama", 
        "givenName": "Masashi", 
        "id": "sg:person.013324706103.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013324706103.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Hospital Organization, Nagoya Medical Center, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.410840.9", 
          "name": [
            "Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan", 
            "National Hospital Organization, Nagoya Medical Center, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hasegawa", 
        "givenName": "Yoshinori", 
        "id": "sg:person.01064452705.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064452705.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan", 
          "id": "http://www.grid.ac/institutes/grid.27476.30", 
          "name": [
            "Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fujishiro", 
        "givenName": "Mitsuhiro", 
        "id": "sg:person.01215720446.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215720446.19"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/bmt.2012.244", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028358194", 
          "https://doi.org/10.1038/bmt.2012.244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/clpt.2011.58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048980159", 
          "https://doi.org/10.1038/clpt.2011.58"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrclinonc.2016.58", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052809547", 
          "https://doi.org/10.1038/nrclinonc.2016.58"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41379-018-0013-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100827894", 
          "https://doi.org/10.1038/s41379-018-0013-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10637-017-0453-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084504012", 
          "https://doi.org/10.1007/s10637-017-0453-0"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2020-03-02", 
    "datePublishedReg": "2020-03-02", 
    "description": "BackgroundLiver injury induced by immune checkpoint inhibitors (ICIs) is an immune-related adverse event (irAE) whose incidence has increased with the broader use of ICIs in clinical practice. However, the incidental risk factors of immune-related liver injury are unknown. We investigated the clinical characteristics of immune-related liver injury.MethodsA total of 546 patients treated with ICIs for advanced malignancies between September 2014 and February 2019 were included retrospectively. Factors associated with immune-related liver injury were determined.ResultsImmune-related liver injury (\u2265\u2009Grade 3) occurred in 29 (5.3%) patients (Grade 3, n\u2009=\u200920; Grade 4, n\u2009=\u20098; Grade 5, n\u2009=\u20091) during the follow-up period (median 153\u00a0days). The patterns of liver injuries were hepatocellular, n\u2009=\u20096 (20.7%); cholestatic, n\u2009=\u200917 (58.6%); and mixed, n\u2009=\u20096 (20.7%). The median period between the initial administration of ICIs and the incidence of irAEs was 52\u00a0days. Of 29 patients with immune-related liver injury (\u2265\u2009Grade 3), four showed immune-related cholangitis with non-obstructive dilation of the bile ducts. Factors that were significantly associated with the incidence of immune-related liver injury in multivariate analysis were use of ipilimumab, anti-cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) agent [hazard ratio [HR] 4.22, 95% confidence interval (CI) 1.65\u201310.80, P\u2009=\u20090.003], and fever over 38\u00a0\u00b0C within 24\u00a0h of initial ICI administration (HR 6.21, 95% CI 2.68\u201314.40, P\u2009<\u20090.001).ConclusionsWe found that the use of ipilimumab and the presence of fever within 24\u00a0h of initial ICI administration were predictive factors for immune-related liver injury.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s00535-020-01677-9", 
    "inLanguage": "en", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1009747", 
        "issn": [
          "0944-1174", 
          "1435-5922"
        ], 
        "name": "Journal of Gastroenterology", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "55"
      }
    ], 
    "keywords": [
      "immune-related adverse events", 
      "immune checkpoint inhibitors", 
      "liver injury", 
      "use of ipilimumab", 
      "ICI administration", 
      "checkpoint inhibitors", 
      "advanced malignancies", 
      "incidence of irAEs", 
      "non-obstructive dilation", 
      "presence of fever", 
      "BackgroundLiver injury", 
      "clinical characteristics", 
      "adverse events", 
      "median period", 
      "bile duct", 
      "predictive factors", 
      "risk factors", 
      "Japanese patients", 
      "initial administration", 
      "clinical practice", 
      "patients", 
      "multivariate analysis", 
      "injury", 
      "incidence", 
      "administration", 
      "ipilimumab", 
      "malignancy", 
      "inhibitors", 
      "cholangitis", 
      "factors", 
      "fever", 
      "dilation", 
      "period", 
      "total", 
      "broad use", 
      "duct", 
      "ResultsImmune", 
      "days", 
      "use", 
      "ConclusionsWe", 
      "agents", 
      "events", 
      "presence", 
      "real-world data", 
      "practice", 
      "patterns", 
      "data", 
      "analysis", 
      "characteristics", 
      "world data", 
      "incidental risk factors", 
      "immune-related liver injury", 
      "lymphocyte-associated antigen 4 (CTLA-4) agent", 
      "antigen 4 (CTLA-4) agent", 
      "initial ICI administration"
    ], 
    "name": "Real world data of liver injury induced by immune checkpoint inhibitors in Japanese patients with advanced malignancies", 
    "pagination": "653-661", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1125320472"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s00535-020-01677-9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "32124082"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s00535-020-01677-9", 
      "https://app.dimensions.ai/details/publication/pub.1125320472"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-01-01T18:58", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_852.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s00535-020-01677-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00535-020-01677-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00535-020-01677-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00535-020-01677-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00535-020-01677-9'


 

This table displays all metadata directly associated to this object as RDF triples.

383 TRIPLES      22 PREDICATES      102 URIs      89 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s00535-020-01677-9 schema:about N1dbc7e07134c4c1098eaf196f04d24f5
2 N400a0dd8db1140f0912c8929cb55da6d
3 N4e960e27446a4bc2b163282fa7e5db5b
4 N62d030c052534b31afee02efa464d2f1
5 N75dd12dfd07c47a2b4024ec9a28d49b7
6 N7e66d5f7ef2042eaa71d5f0d2d23f873
7 N8446896034cc4bd08a560356a93b3e60
8 N87cd5c3e7ca14656bef93cf63cef4486
9 N97f3a47624d341cabd0e06fc05bca99b
10 N9fe0b3babbe0452cb5101739f3626d5e
11 Na37986337e594f9e8121ba3e826d2fc7
12 Nc7fb39e570b64409afbfd56f12ee9d3f
13 Ncb63a4b9e30847d18d9793adfd0324c1
14 Ncfcfcb2d8b83466c91d2b69fc8ea708b
15 Ne8cf611d8e03457abfc720e67c908da0
16 Ne8dc15cf91c442559d05383869d31971
17 anzsrc-for:11
18 anzsrc-for:1107
19 schema:author N6443dbd385744ed88fcf5e468bb26587
20 schema:citation sg:pub.10.1007/s10637-017-0453-0
21 sg:pub.10.1038/bmt.2012.244
22 sg:pub.10.1038/clpt.2011.58
23 sg:pub.10.1038/nrclinonc.2016.58
24 sg:pub.10.1038/s41379-018-0013-y
25 schema:datePublished 2020-03-02
26 schema:datePublishedReg 2020-03-02
27 schema:description BackgroundLiver injury induced by immune checkpoint inhibitors (ICIs) is an immune-related adverse event (irAE) whose incidence has increased with the broader use of ICIs in clinical practice. However, the incidental risk factors of immune-related liver injury are unknown. We investigated the clinical characteristics of immune-related liver injury.MethodsA total of 546 patients treated with ICIs for advanced malignancies between September 2014 and February 2019 were included retrospectively. Factors associated with immune-related liver injury were determined.ResultsImmune-related liver injury (≥ Grade 3) occurred in 29 (5.3%) patients (Grade 3, n = 20; Grade 4, n = 8; Grade 5, n = 1) during the follow-up period (median 153 days). The patterns of liver injuries were hepatocellular, n = 6 (20.7%); cholestatic, n = 17 (58.6%); and mixed, n = 6 (20.7%). The median period between the initial administration of ICIs and the incidence of irAEs was 52 days. Of 29 patients with immune-related liver injury (≥ Grade 3), four showed immune-related cholangitis with non-obstructive dilation of the bile ducts. Factors that were significantly associated with the incidence of immune-related liver injury in multivariate analysis were use of ipilimumab, anti-cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) agent [hazard ratio [HR] 4.22, 95% confidence interval (CI) 1.65–10.80, P = 0.003], and fever over 38 °C within 24 h of initial ICI administration (HR 6.21, 95% CI 2.68–14.40, P < 0.001).ConclusionsWe found that the use of ipilimumab and the presence of fever within 24 h of initial ICI administration were predictive factors for immune-related liver injury.
28 schema:genre article
29 schema:inLanguage en
30 schema:isAccessibleForFree false
31 schema:isPartOf N693999a20cf843868fe0dedade47df7d
32 Nd441ce7ec494482b8c1acdacebe908f7
33 sg:journal.1009747
34 schema:keywords BackgroundLiver injury
35 ConclusionsWe
36 ICI administration
37 Japanese patients
38 ResultsImmune
39 administration
40 advanced malignancies
41 adverse events
42 agents
43 analysis
44 antigen 4 (CTLA-4) agent
45 bile duct
46 broad use
47 characteristics
48 checkpoint inhibitors
49 cholangitis
50 clinical characteristics
51 clinical practice
52 data
53 days
54 dilation
55 duct
56 events
57 factors
58 fever
59 immune checkpoint inhibitors
60 immune-related adverse events
61 immune-related liver injury
62 incidence
63 incidence of irAEs
64 incidental risk factors
65 inhibitors
66 initial ICI administration
67 initial administration
68 injury
69 ipilimumab
70 liver injury
71 lymphocyte-associated antigen 4 (CTLA-4) agent
72 malignancy
73 median period
74 multivariate analysis
75 non-obstructive dilation
76 patients
77 patterns
78 period
79 practice
80 predictive factors
81 presence
82 presence of fever
83 real-world data
84 risk factors
85 total
86 use
87 use of ipilimumab
88 world data
89 schema:name Real world data of liver injury induced by immune checkpoint inhibitors in Japanese patients with advanced malignancies
90 schema:pagination 653-661
91 schema:productId N7baa003412ff4824a19121369e1547ed
92 N90d6b8355d0e47b9a906970a5d7734c9
93 Naf20718f4c03473e9335369a6763ee5d
94 schema:sameAs https://app.dimensions.ai/details/publication/pub.1125320472
95 https://doi.org/10.1007/s00535-020-01677-9
96 schema:sdDatePublished 2022-01-01T18:58
97 schema:sdLicense https://scigraph.springernature.com/explorer/license/
98 schema:sdPublisher Nca4ba530ef1d40fa96f741f18c5a6c07
99 schema:url https://doi.org/10.1007/s00535-020-01677-9
100 sgo:license sg:explorer/license/
101 sgo:sdDataset articles
102 rdf:type schema:ScholarlyArticle
103 N1dbc7e07134c4c1098eaf196f04d24f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Humans
105 rdf:type schema:DefinedTerm
106 N30a1d71f2ebd43cb89f793a4a83516fd rdf:first sg:person.012312611762.94
107 rdf:rest Ne354cec7c23e4b29ae7789c9226e231c
108 N319b9f08d36048f0991cf77841d9d519 rdf:first sg:person.013004313704.19
109 rdf:rest N4fb33ae262824ad38ba3e8a494b7b14a
110 N400a0dd8db1140f0912c8929cb55da6d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Male
112 rdf:type schema:DefinedTerm
113 N437c8529554744f0b14d44da5073da07 rdf:first sg:person.01212503247.23
114 rdf:rest N921d7acddb3342fcb90d848a6c0cb366
115 N492fa50eb44f463a838c7887828efacd rdf:first sg:person.0774403755.85
116 rdf:rest N5c3fa0216d014212a9582b3762cd85f3
117 N4e960e27446a4bc2b163282fa7e5db5b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Neoplasms
119 rdf:type schema:DefinedTerm
120 N4fb33ae262824ad38ba3e8a494b7b14a rdf:first sg:person.01343614333.92
121 rdf:rest N6f38c2e5aed3476494fa0f71497a70d9
122 N5c3fa0216d014212a9582b3762cd85f3 rdf:first sg:person.0617426112.12
123 rdf:rest N67dba73d57114b6c9ebb1c130c92823b
124 N5c45ffeb7d264607b56659a644799d69 rdf:first sg:person.01035104457.90
125 rdf:rest Nbbfbe61385de4c9ebd5b3012e351f47e
126 N62d030c052534b31afee02efa464d2f1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Middle Aged
128 rdf:type schema:DefinedTerm
129 N6387af55012944698e6211951987a5a2 rdf:first sg:person.01062370120.20
130 rdf:rest N492fa50eb44f463a838c7887828efacd
131 N639e54d0c5fd4db08d76a1d0615477be rdf:first sg:person.01147235443.61
132 rdf:rest N30a1d71f2ebd43cb89f793a4a83516fd
133 N6443dbd385744ed88fcf5e468bb26587 rdf:first sg:person.07374462067.98
134 rdf:rest Nd345718e101d4caeac155a19fc115a9d
135 N66c09d7ddf8a4fa69847d9bb2a591c8e rdf:first sg:person.01166316575.80
136 rdf:rest N5c45ffeb7d264607b56659a644799d69
137 N67dba73d57114b6c9ebb1c130c92823b rdf:first sg:person.0732632701.74
138 rdf:rest Ne1189005689c4c768e802e1930ac2909
139 N693999a20cf843868fe0dedade47df7d schema:issueNumber 6
140 rdf:type schema:PublicationIssue
141 N6f38c2e5aed3476494fa0f71497a70d9 rdf:first sg:person.0675666250.10
142 rdf:rest N639e54d0c5fd4db08d76a1d0615477be
143 N75dd12dfd07c47a2b4024ec9a28d49b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Aged
145 rdf:type schema:DefinedTerm
146 N7baa003412ff4824a19121369e1547ed schema:name doi
147 schema:value 10.1007/s00535-020-01677-9
148 rdf:type schema:PropertyValue
149 N7e66d5f7ef2042eaa71d5f0d2d23f873 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Immune Checkpoint Inhibitors
151 rdf:type schema:DefinedTerm
152 N8446896034cc4bd08a560356a93b3e60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Risk Factors
154 rdf:type schema:DefinedTerm
155 N87cd5c3e7ca14656bef93cf63cef4486 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Female
157 rdf:type schema:DefinedTerm
158 N90d6b8355d0e47b9a906970a5d7734c9 schema:name pubmed_id
159 schema:value 32124082
160 rdf:type schema:PropertyValue
161 N921d7acddb3342fcb90d848a6c0cb366 rdf:first sg:person.01255644630.09
162 rdf:rest N66c09d7ddf8a4fa69847d9bb2a591c8e
163 N97f3a47624d341cabd0e06fc05bca99b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
164 schema:name Time Factors
165 rdf:type schema:DefinedTerm
166 N9fe0b3babbe0452cb5101739f3626d5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Japan
168 rdf:type schema:DefinedTerm
169 Na37986337e594f9e8121ba3e826d2fc7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Follow-Up Studies
171 rdf:type schema:DefinedTerm
172 Naf20718f4c03473e9335369a6763ee5d schema:name dimensions_id
173 schema:value pub.1125320472
174 rdf:type schema:PropertyValue
175 Nb56376803b7f4f6f809ab41ca8f3e149 rdf:first sg:person.01215720446.19
176 rdf:rest rdf:nil
177 Nbbfbe61385de4c9ebd5b3012e351f47e rdf:first sg:person.0577356402.63
178 rdf:rest Ndc015dafcaee43ab8400e566200fb776
179 Nc436f62af9944dafbe40c5f92a7f6c74 rdf:first sg:person.013324706103.19
180 rdf:rest Nff777c8c93564b39996f67de11c37093
181 Nc7fb39e570b64409afbfd56f12ee9d3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Retrospective Studies
183 rdf:type schema:DefinedTerm
184 Nca4ba530ef1d40fa96f741f18c5a6c07 schema:name Springer Nature - SN SciGraph project
185 rdf:type schema:Organization
186 Ncb63a4b9e30847d18d9793adfd0324c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Incidence
188 rdf:type schema:DefinedTerm
189 Ncfcfcb2d8b83466c91d2b69fc8ea708b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Ipilimumab
191 rdf:type schema:DefinedTerm
192 Nd345718e101d4caeac155a19fc115a9d rdf:first sg:person.0641441563.04
193 rdf:rest N6387af55012944698e6211951987a5a2
194 Nd441ce7ec494482b8c1acdacebe908f7 schema:volumeNumber 55
195 rdf:type schema:PublicationVolume
196 Ndc015dafcaee43ab8400e566200fb776 rdf:first sg:person.01211606464.55
197 rdf:rest N319b9f08d36048f0991cf77841d9d519
198 Ne1189005689c4c768e802e1930ac2909 rdf:first sg:person.01273031773.59
199 rdf:rest Ne7e59832efe444efa6a55e20e2ae2a04
200 Ne354cec7c23e4b29ae7789c9226e231c rdf:first sg:person.013237674417.91
201 rdf:rest Nc436f62af9944dafbe40c5f92a7f6c74
202 Ne7e59832efe444efa6a55e20e2ae2a04 rdf:first sg:person.010767423067.71
203 rdf:rest N437c8529554744f0b14d44da5073da07
204 Ne8cf611d8e03457abfc720e67c908da0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name Chemical and Drug Induced Liver Injury
206 rdf:type schema:DefinedTerm
207 Ne8dc15cf91c442559d05383869d31971 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Fever
209 rdf:type schema:DefinedTerm
210 Nff777c8c93564b39996f67de11c37093 rdf:first sg:person.01064452705.07
211 rdf:rest Nb56376803b7f4f6f809ab41ca8f3e149
212 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
213 schema:name Medical and Health Sciences
214 rdf:type schema:DefinedTerm
215 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
216 schema:name Immunology
217 rdf:type schema:DefinedTerm
218 sg:journal.1009747 schema:issn 0944-1174
219 1435-5922
220 schema:name Journal of Gastroenterology
221 schema:publisher Springer Nature
222 rdf:type schema:Periodical
223 sg:person.01035104457.90 schema:affiliation grid-institutes:grid.437848.4
224 schema:familyName Maeda
225 schema:givenName Osamu
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01035104457.90
227 rdf:type schema:Person
228 sg:person.01062370120.20 schema:affiliation grid-institutes:grid.27476.30
229 schema:familyName Ishigami
230 schema:givenName Masatoshi
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01062370120.20
232 rdf:type schema:Person
233 sg:person.01064452705.07 schema:affiliation grid-institutes:grid.410840.9
234 schema:familyName Hasegawa
235 schema:givenName Yoshinori
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01064452705.07
237 rdf:type schema:Person
238 sg:person.010767423067.71 schema:affiliation grid-institutes:grid.416762.0
239 schema:familyName Inukai
240 schema:givenName Yosuke
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010767423067.71
242 rdf:type schema:Person
243 sg:person.01147235443.61 schema:affiliation grid-institutes:grid.27476.30
244 schema:familyName Sone
245 schema:givenName Michihiko
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01147235443.61
247 rdf:type schema:Person
248 sg:person.01166316575.80 schema:affiliation grid-institutes:grid.27476.30
249 schema:familyName Hase
250 schema:givenName Tetsunari
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01166316575.80
252 rdf:type schema:Person
253 sg:person.01211606464.55 schema:affiliation grid-institutes:grid.27476.30
254 schema:familyName Nagino
255 schema:givenName Masato
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211606464.55
257 rdf:type schema:Person
258 sg:person.01212503247.23 schema:affiliation grid-institutes:grid.416762.0
259 schema:familyName Toyoda
260 schema:givenName Hidenori
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01212503247.23
262 rdf:type schema:Person
263 sg:person.01215720446.19 schema:affiliation grid-institutes:grid.27476.30
264 schema:familyName Fujishiro
265 schema:givenName Mitsuhiro
266 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215720446.19
267 rdf:type schema:Person
268 sg:person.012312611762.94 schema:affiliation grid-institutes:grid.27476.30
269 schema:familyName Gotoh
270 schema:givenName Momokazu
271 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012312611762.94
272 rdf:type schema:Person
273 sg:person.01255644630.09 schema:affiliation grid-institutes:grid.27476.30
274 schema:familyName Yokota
275 schema:givenName Kenji
276 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255644630.09
277 rdf:type schema:Person
278 sg:person.01273031773.59 schema:affiliation grid-institutes:grid.437848.4
279 schema:familyName Kawashima
280 schema:givenName Hiroki
281 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01273031773.59
282 rdf:type schema:Person
283 sg:person.013004313704.19 schema:affiliation grid-institutes:grid.27476.30
284 schema:familyName Hibi
285 schema:givenName Hideharu
286 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013004313704.19
287 rdf:type schema:Person
288 sg:person.013237674417.91 schema:affiliation grid-institutes:grid.437848.4
289 schema:familyName Ando
290 schema:givenName Yuichi
291 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013237674417.91
292 rdf:type schema:Person
293 sg:person.013324706103.19 schema:affiliation grid-institutes:grid.27476.30
294 schema:familyName Akiyama
295 schema:givenName Masashi
296 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013324706103.19
297 rdf:type schema:Person
298 sg:person.01343614333.92 schema:affiliation grid-institutes:grid.27476.30
299 schema:familyName Kodera
300 schema:givenName Yasuhiro
301 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01343614333.92
302 rdf:type schema:Person
303 sg:person.0577356402.63 schema:affiliation grid-institutes:grid.27476.30
304 schema:familyName Kiyoi
305 schema:givenName Hitoshi
306 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577356402.63
307 rdf:type schema:Person
308 sg:person.0617426112.12 schema:affiliation grid-institutes:grid.27476.30
309 schema:familyName Kuzuya
310 schema:givenName Teiji
311 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0617426112.12
312 rdf:type schema:Person
313 sg:person.0641441563.04 schema:affiliation grid-institutes:grid.27476.30
314 schema:familyName Ito
315 schema:givenName Takanori
316 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641441563.04
317 rdf:type schema:Person
318 sg:person.0675666250.10 schema:affiliation grid-institutes:grid.27476.30
319 schema:familyName Fujimoto
320 schema:givenName Yasushi
321 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0675666250.10
322 rdf:type schema:Person
323 sg:person.0732632701.74 schema:affiliation grid-institutes:grid.27476.30
324 schema:familyName Honda
325 schema:givenName Takashi
326 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0732632701.74
327 rdf:type schema:Person
328 sg:person.07374462067.98 schema:affiliation grid-institutes:grid.27476.30
329 schema:familyName Mizuno
330 schema:givenName Kazuyuki
331 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07374462067.98
332 rdf:type schema:Person
333 sg:person.0774403755.85 schema:affiliation grid-institutes:grid.27476.30
334 schema:familyName Ishizu
335 schema:givenName Yoji
336 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0774403755.85
337 rdf:type schema:Person
338 sg:pub.10.1007/s10637-017-0453-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084504012
339 https://doi.org/10.1007/s10637-017-0453-0
340 rdf:type schema:CreativeWork
341 sg:pub.10.1038/bmt.2012.244 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028358194
342 https://doi.org/10.1038/bmt.2012.244
343 rdf:type schema:CreativeWork
344 sg:pub.10.1038/clpt.2011.58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048980159
345 https://doi.org/10.1038/clpt.2011.58
346 rdf:type schema:CreativeWork
347 sg:pub.10.1038/nrclinonc.2016.58 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052809547
348 https://doi.org/10.1038/nrclinonc.2016.58
349 rdf:type schema:CreativeWork
350 sg:pub.10.1038/s41379-018-0013-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1100827894
351 https://doi.org/10.1038/s41379-018-0013-y
352 rdf:type schema:CreativeWork
353 grid-institutes:grid.27476.30 schema:alternateName Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
354 Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Japan
355 Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan
356 Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
357 Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
358 Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
359 Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
360 Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan
361 Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
362 schema:name Department of Dermatology, Nagoya University Graduate School of Medicine, Nagoya, Japan
363 Department of Gastroenterological Surgery (Surgery II), Nagoya University Graduate School of Medicine, Nagoya, Japan
364 Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan
365 Department of Hematology and Oncology, Nagoya University Graduate School of Medicine, Nagoya, Japan
366 Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
367 Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
368 Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
369 Department of Urology, Nagoya University Graduate School of Medicine, Nagoya, Japan
370 Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
371 rdf:type schema:Organization
372 grid-institutes:grid.410840.9 schema:alternateName National Hospital Organization, Nagoya Medical Center, Nagoya, Japan
373 schema:name Department of Respiratory Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan
374 National Hospital Organization, Nagoya Medical Center, Nagoya, Japan
375 rdf:type schema:Organization
376 grid-institutes:grid.416762.0 schema:alternateName Department of Gastroenterology and Hepatology, Ogaki Municipal Hospital, Ogaki, Japan
377 schema:name Department of Gastroenterology and Hepatology, Ogaki Municipal Hospital, Ogaki, Japan
378 rdf:type schema:Organization
379 grid-institutes:grid.437848.4 schema:alternateName Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya, Japan
380 Department of Endoscopy, Nagoya University Hospital, Nagoya, Japan
381 schema:name Department of Clinical Oncology and Chemotherapy, Nagoya University Hospital, Nagoya, Japan
382 Department of Endoscopy, Nagoya University Hospital, Nagoya, Japan
383 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...