Hepatic FATP5 expression is associated with histological progression and loss of hepatic fat in NAFLD patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-10-10

AUTHORS

Kenichiro Enooku, Takeya Tsutsumi, Mayuko Kondo, Naoto Fujiwara, Takayoshi Sasako, Junji Shibahara, Akira Kado, Kazuya Okushin, Hidetaka Fujinaga, Ryo Nakagomi, Tatsuya Minami, Masaya Sato, Koji Uchino, Hayato Nakagawa, Yuji Kondo, Yoshinari Asaoka, Ryosuke Tateishi, Kohjiro Ueki, Hitoshi Ikeda, Haruhiko Yoshida, Kyoji Moriya, Hiroshi Yotsuyanagi, Takashi Kadowaki, Kazuhiko Koike

ABSTRACT

BackgroundNonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) are characterized by the accumulation of excess hepatic fat. However, in the progression from NASH to cirrhosis, hepatic fat is often lost. Our aim was to elucidate the mechanism underlying hepatic fat loss during NASH progression.MethodsLiver biopsies were performed at The University of Tokyo Hospital between November 2011 and March 2016 on 146 patients with NAFLD and 14 patients with cryptogenic cirrhosis who were not being treated with any diabetes or dyslipidemia drugs. Among them, 70 patients underwent liver biopsy after an overnight fast, and 90 patients were biopsied 5 h after an oral glucose tolerance test. Expression differences in genes encoding several fatty acid metabolism-related factors were examined and correlated with hepatic histological changes based on NAFLD activity scores. Prospective patient follow-up continued until June 2018.ResultsThe level of fatty acid transport protein 5 (FATP5), which is associated with free fatty acid intake, was significantly and inversely correlated with features of histological progression, including ballooning and fibrosis. This was confirmed by immunohistochemical analysis. Transcript levels of genes encoding fatty acid metabolism-related proteins were comparable between NASH with severe fibrosis and cryptogenic cirrhosis. Furthermore, a prospective cohort study demonstrated that low FATP5 expression was the most significant risk factor for hepatic fat loss.ConclusionsDecreased hepatic FATP5 expression in NAFLD is linked to histological progression, and may be associated with hepatic fat loss during NASH progression to cirrhosis. More... »

PAGES

227-243

Journal

TITLE

Journal of Gastroenterology

ISSUE

2

VOLUME

55

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00535-019-01633-2

DOI

http://dx.doi.org/10.1007/s00535-019-01633-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1121652706

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/31602526


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