Prospective study of early chronic pancreatitis diagnosed based on the Japanese diagnostic criteria View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-07-03

AUTHORS

Atsushi Masamune, Tatsuhide Nabeshima, Kazuhiro Kikuta, Shin Hamada, Eriko Nakano, Kiyoshi Kume, Atsushi Kanno, Ai Sato, Yuichi Tachibana, Osamu Inatomi, Satoshi Yamamoto, Tsukasa Ikeura, Seiji Futagami, Masashi Taguchi, Keiji Hanada, Kyoko Shimizu, Masanobu Kageoka, Tomotaka Saito, Takaaki Eguchi, Kensuke Kubota, Mamoru Takenaka, Atsushi Mima, Atsushi Irisawa, Tetsuhide Ito, Akira Andoh, Kazuo Inui, Yoshifumi Takeyama, Hiroki Yamaue, Kazuichi Okazaki, Tooru Shimosegawa

ABSTRACT

BackgroundChronic pancreatitis (CP) is a fibro-inflammatory disease of the pancreas. Early diagnosis and intervention, before CP becomes established and irreversible, are essential to improve the long-term outcomes. The world’s first diagnostic criteria for early CP were proposed in Japan in 2009, but their clinical utility remains elusive. This study aimed to clarify whether patients with early CP progress to definite CP.MethodsThis is a multicenter, prospective study. Patients diagnosed as having early CP according to the Japanese diagnostic criteria were prospectively followed for 2 years. Clinical profiles including symptoms, drinking and smoking status, laboratory data, imaging findings and treatments were analyzed.ResultsAmong the 83 patients who completed the 2-year follow-up period, four (4.8%) patients progressed to definite CP. The diagnosis of 48 (57.8%) patients was unchanged, and that of 31 (37.3%) patients was downgraded. All the four progressive patients were male, alcohol-related, smokers (3 current and 1 ever), and continued drinking. Comparison of the clinical profiles between the progression group (n = 4) and non-progression group (n = 79) revealed that etiology (alcohol-related), smoking status and presence of acute pancreatitis episodes were associated with the progression to definite CP.ConclusionsThe Japanese diagnostic criteria could identify some patients before the progression to definite CP, while the majority of the patients did not progress. Trial registration number: UMIN000015992. More... »

PAGES

928-935

References to SciGraph publications

  • 2017-09-07. Chronic pancreatitis in NATURE REVIEWS DISEASE PRIMERS
  • 2017-01-27. Nationwide epidemiological survey of early chronic pancreatitis in Japan in JOURNAL OF GASTROENTEROLOGY
  • 2017-08-01. Chronic Pancreatitis and Pancreatic Cancer Risk: A Systematic Review and Meta-analysis in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2010-04-28. The revised Japanese clinical diagnostic criteria for chronic pancreatitis in JOURNAL OF GASTROENTEROLOGY
  • 2012-05-22. Natural History Following the First Attack of Acute Pancreatitis in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • Journal

    TITLE

    Journal of Gastroenterology

    ISSUE

    10

    VOLUME

    54

    Author Affiliations

  • Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Japan
  • Department of Gastroenterology, Dokkyo Medical University School of Medicine, Mibu, Japan
  • Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
  • Department of Medicine, Shiga University of Medical Science, Otsu, Japan
  • Department of Gastroenterology, Bantane Hospital, Fujita Health University, Nagoya, Japan
  • Department of Gastroenterology and Hepatology, Kansai Medical University, Osaka, Japan
  • Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School, Tokyo, Japan
  • Third Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
  • Department of Gastroenterology, JA Onomichi General Hospital, Onomichi, Japan
  • Department of Gastroenterology, Tokyo Women’s Medical University, Tokyo, Japan
  • Department of Gastroenterology, Fujieda Municipal Hospital, Fujieda, Japan
  • Department of Gastroenterology, University of Tokyo, Tokyo, Japan
  • Department of Gastroenterology and Hepatology, Osaka Saiseikai Nakatsu Hospital, Osaka, Japan
  • Department of Endoscopy, Yokohama City University Hospital, Yokohama, Japan
  • Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan
  • Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
  • Department of Surgery, Kindai University Faculty of Medicine, Osaka, Japan
  • Second Department of Surgery, Wakayama Medical University, Wakayama, Japan
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00535-019-01602-9

    DOI

    http://dx.doi.org/10.1007/s00535-019-01602-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1117731322

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31270692


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