Molecular subtype switching in early-stage gastric cancers with multiple occurrences View Full Text


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Article Info

DATE

2019-01-21

AUTHORS

Shinya Takaoka, Yosuke Hirotsu, Hiroshi Ohyama, Hitoshi Mochizuki, Kenji Amemiya, Toshio Oyama, Hiroshi Ashizawa, Dai Yoshimura, Keiko Nakagomi, Kenji Hosoda, Yoji Suzuki, Yuichiro Kojima, Masao Omata

ABSTRACT

BackgroundMultiple gastric cancers at the same time (synchronous) or recurrence after 1 year (metachronous) are frequently encountered. Since their genetic profiles were not well elucidated, we molecularly subtyped the genetic events of synchronous and metachronous early-stage gastric cancers.MethodsWe studied mismatch repair (MMR) genes in 84 tumors from 31 patients (15 synchronous and 16 metachronous) by immunohistochemistry. We performed microsatellite instability analysis and targeted sequencing of 58 significantly mutated genes (SMGs) in 35 tumors from thirteen patients. Genomic data from TCGA were used for comparisons with advanced-stage cancers.ResultsAmong the 31 patients, at least one deficient-MMR (dMMR) tumor was observed in eight (26%). Of eight patients, seven showed a mixture of proficient-MMR (pMMR) and dMMR tumors. The one case with only dMMR had six recurrent tumors within 2 years. To further subtype, we sequenced 58 SMGs in 35 samples (25 pMMR and 10 dMMR) from thirteen patients. In 35 samples, 163 mutations were identified, but none matched in almost cases, strongly indicating different clonal origins, whether synchronous or metachronous occurrences. Of the 25 pMMR cases, 1 belonged to Epstein–Barr virus (EBV), 24 belonged to chromosomal instability (CIN) subtypes. Of the thirteen cases, repetitive CIN, a mixture of CIN and MSI, a mixture of CIN and EBV, and repetitive MSI were observed in nine (70%), two (15%), one (8%) and one (8%), respectively. ConclusionsDespite multiple tumors occurring in the same patient simultaneously or several years apart, clonal origin was totally different. ‘Switching’ or ‘mixing’ of dMMR and pMMR, EBV or CIN occurred, which had clinical relevance with regard to immunotherapy. More... »

PAGES

674-686

References to SciGraph publications

  • 2010-06-18. Mutations in TGFbeta-RII and BAXmediate tumor progression in the later stages of colorectal cancer with microsatellite instability in BMC CANCER
  • 2014-10-18. Risk factors for synchronous or metachronous tumor development after endoscopic resection of gastric neoplasms in GASTRIC CANCER
  • 2007-06-04. Assessment of MLH1 promoter methylation in relation to gene expression requires specific analysis in ONCOGENE
  • 2015-09-29. Incidence of and risk factors for metachronous gastric cancer after endoscopic resection and successful Helicobacter pylori eradication: results of a large-scale, multicenter cohort study in Japan in GASTRIC CANCER
  • 2014-05-11. Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer in NATURE GENETICS
  • 2016-10-26. Comparison between two amplicon-based sequencing panels of different scales in the detection of somatic mutations associated with gastric cancer in BMC GENOMICS
  • 2014-07-23. Comprehensive molecular characterization of gastric adenocarcinoma in NATURE
  • 2014-05-11. Recurrent gain-of-function mutations of RHOA in diffuse-type gastric carcinoma in NATURE GENETICS
  • 2006-12-19. Assessment of microsatellite instability status for the prediction of metachronous recurrence after initial endoscopic submucosal dissection for early gastric cancer in BRITISH JOURNAL OF CANCER
  • 2011-10-30. Exome sequencing identifies frequent mutation of ARID1A in molecular subtypes of gastric cancer in NATURE GENETICS
  • 2014-11-19. Genomic landscape and genetic heterogeneity in gastric adenocarcinoma revealed by whole-genome sequencing in NATURE COMMUNICATIONS
  • 2012-04-08. Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes in NATURE GENETICS
  • 2018-07-16. Comprehensive molecular characterization of clinical responses to PD-1 inhibition in metastatic gastric cancer in NATURE MEDICINE
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    https://app.dimensions.ai/details/publication/pub.1111577150

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/30666417


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        "description": "BackgroundMultiple gastric cancers at the same time (synchronous) or recurrence after 1\u00a0year (metachronous) are frequently encountered. Since their genetic profiles were not well elucidated, we molecularly subtyped the genetic events of synchronous and metachronous early-stage gastric cancers.MethodsWe studied mismatch repair (MMR) genes in 84 tumors from 31 patients (15 synchronous and 16 metachronous) by immunohistochemistry.\n We performed microsatellite instability analysis and targeted sequencing of 58 significantly mutated genes (SMGs) in 35 tumors from thirteen patients. Genomic data from TCGA were used for comparisons with advanced-stage cancers.ResultsAmong the 31 patients, at least one deficient-MMR (dMMR) tumor was observed in eight (26%). Of eight patients, seven showed a mixture of proficient-MMR (pMMR) and dMMR tumors. The one case with only dMMR had six recurrent tumors within 2\u00a0years. To further subtype, we sequenced 58 SMGs in 35 samples (25 pMMR and 10 dMMR) from thirteen patients. In 35 samples, 163 mutations were identified, but none matched in almost cases, strongly indicating different clonal origins, whether synchronous or metachronous occurrences. Of the 25 pMMR cases, 1 belonged to Epstein\u2013Barr virus (EBV), 24 belonged to chromosomal instability (CIN) subtypes. Of the thirteen cases, repetitive CIN, a mixture of CIN and MSI, a mixture of CIN and EBV, and repetitive MSI were observed in nine (70%), two (15%), one (8%) and one (8%), respectively.\nConclusionsDespite multiple tumors occurring in the same patient simultaneously or several years apart, clonal origin was totally different. \u2018Switching\u2019 or \u2018mixing\u2019 of dMMR and pMMR, EBV or CIN occurred, which had clinical relevance with regard to immunotherapy.", 
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