NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-09

AUTHORS

Yoichi Kakuta, Yosuke Kawai, Daisuke Okamoto, Tetsuya Takagawa, Kentaro Ikeya, Hirotake Sakuraba, Atsushi Nishida, Shoko Nakagawa, Miki Miura, Takahiko Toyonaga, Kei Onodera, Masaru Shinozaki, Yoh Ishiguro, Shinta Mizuno, Masahiro Takahara, Shunichi Yanai, Ryota Hokari, Tomoo Nakagawa, Hiroshi Araki, Satoshi Motoya, Takeo Naito, Rintaro Moroi, Hisashi Shiga, Katsuya Endo, Taku Kobayashi, Makoto Naganuma, Sakiko Hiraoka, Takayuki Matsumoto, Shiro Nakamura, Hiroshi Nakase, Tadakazu Hisamatsu, Makoto Sasaki, Hiroyuki Hanai, Akira Andoh, Masao Nagasaki, Yoshitaka Kinouchi, Tooru Shimosegawa, Atsushi Masamune, Yasuo Suzuki, for the MENDEL study group

ABSTRACT

BACKGROUND: Despite NUDT15 variants showing significant association with thiopurine-induced adverse events (AEs) in Asians, it remains unclear which variants of NUDT15 or whether additional genetic variants should be tested to predict AEs. To clarify the best pharmacogenetic test to be used clinically, we performed association studies of NUDT15 variants and haplotypes with AEs, genome-wide association study (GWAS) to discover additional variants, and ROC analysis to select the model to predict severe AEs. METHODS: Overall, 2630 patients with inflammatory bowel disease (IBD) were enrolled and genotyped for NUDT15 codon 139; 1291 patients were treated with thiopurines. diplotypes were analyzed in 970 patients, and GWASs of AEs were performed with 1221 patients using population-optimized genotyping array and imputation. RESULTS: We confirmed the association of NUDT15 p.Arg139Cys with leukopenia and alopecia (p = 2.20E-63, 1.32E-69, OR = 6.59, 12.1, respectively), and found a novel association with digestive symptoms (p = 6.39E-04, OR = 1.89). Time to leukopenia was significantly shorter, and when leukopenia was diagnosed, thiopurine doses were significantly lower in Arg/Cys and Cys/Cys than in Arg/Arg. In GWASs, no additional variants were found to be associated with thiopurine-induced AEs. Despite strong correlation of leukopenia frequency with estimated enzyme activities based on the diplotypes (r2 = 0.926, p = 0.0087), there were no significant differences in the AUCs of diplotypes from those of codon 139 to predict severe AEs (AUC = 0.916, 0.921, for acute severe leukopenia, AUC = 0.990, 0.991, for severe alopecia, respectively). CONCLUSIONS: Genotyping of NUDT15 codon 139 was sufficient to predict acute severe leukopenia and alopecia in Japanese patients with IBD. More... »

PAGES

1065-1078

References to SciGraph publications

  • 2003-08. Low-dose azathioprine is effective and safe for maintenance of remission in patients with ulcerative colitis in JOURNAL OF GASTROENTEROLOGY
  • 2016-06. NUDT15 R139C causes thiopurine-induced early severe hair loss and leukopenia in Japanese patients with IBD in THE PHARMACOGENOMICS JOURNAL
  • 2015-10. Japonica array: improved genotype imputation by designing a population-specific SNP array with 1070 Japanese individuals in JOURNAL OF HUMAN GENETICS
  • 2014-10. HLA-DQA1-HLA-DRB1 variants confer susceptibility to pancreatitis induced by thiopurine immunosuppressants in NATURE GENETICS
  • 2015-12. Second-generation PLINK: rising to the challenge of larger and richer datasets in GIGASCIENCE
  • 2009-03. Thiopurine S-methyltransferase and inosine triphosphate pyrophosphohydrolase genes in Japanese patients with inflammatory bowel disease in whom adverse drug reactions were induced by azathioprine/6-mercaptopurine treatment in JOURNAL OF GASTROENTEROLOGY
  • 2014-09. A common missense variant in NUDT15 confers susceptibility to thiopurine-induced leukopenia in NATURE GENETICS
  • 2010-10. The multidrug-resistance protein 4 polymorphism is a new factor accounting for thiopurine sensitivity in Japanese patients with inflammatory bowel disease in JOURNAL OF GASTROENTEROLOGY
  • 2018-03. Evidence-based clinical practice guidelines for inflammatory bowel disease in JOURNAL OF GASTROENTEROLOGY
  • 2011-04. Efficacy of Immunosuppressive Therapy for Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2018-03. Interaction between NUDT15 and ABCC4 variants enhances intolerability of 6-mercaptopurine in Japanese patients with childhood acute lymphoblastic leukemia in THE PHARMACOGENOMICS JOURNAL
  • 2015-12. Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals in NATURE COMMUNICATIONS
  • 2016-04. NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity in NATURE GENETICS
  • 2016-11. Reference-based phasing using the Haplotype Reference Consortium panel in NATURE GENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00535-018-1486-7

    DOI

    http://dx.doi.org/10.1007/s00535-018-1486-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1104986865

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/29923122


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Clinical Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Tohoku University", 
              "id": "https://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, 980-8574, Sendai, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kakuta", 
            "givenName": "Yoichi", 
            "id": "sg:person.01262023114.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262023114.94"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Tokyo", 
              "id": "https://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan", 
                "Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kawai", 
            "givenName": "Yosuke", 
            "id": "sg:person.01247410770.79", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247410770.79"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tohoku University", 
              "id": "https://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, 980-8574, Sendai, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Okamoto", 
            "givenName": "Daisuke", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hyogo College of Medicine", 
              "id": "https://www.grid.ac/institutes/grid.272264.7", 
              "name": [
                "Division of Internal Medicine, Department of Inflammatory Bowel Disease, Hyogo College of Medicine, Nishinomiya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takagawa", 
            "givenName": "Tetsuya", 
            "id": "sg:person.012740104303.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012740104303.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Centre for Gastroenterology and Inflammatory Bowel Disease Research, Hamamatsu South Hospital, Hamamatsu, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ikeya", 
            "givenName": "Kentaro", 
            "id": "sg:person.01307150160.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307150160.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hirosaki University", 
              "id": "https://www.grid.ac/institutes/grid.257016.7", 
              "name": [
                "Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sakuraba", 
            "givenName": "Hirotake", 
            "id": "sg:person.015750664004.19", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015750664004.19"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Shiga University of Medical Science", 
              "id": "https://www.grid.ac/institutes/grid.410827.8", 
              "name": [
                "Department of Gastroenterology, Shiga University of Medical Science, Otsu, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nishida", 
            "givenName": "Atsushi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Aichi Medical University", 
              "id": "https://www.grid.ac/institutes/grid.411234.1", 
              "name": [
                "Division of Gastroenterology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakagawa", 
            "givenName": "Shoko", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kyorin University", 
              "id": "https://www.grid.ac/institutes/grid.411205.3", 
              "name": [
                "The Third Department of Internal Medicine, Kyorin University School of Medicine, Mitaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Miura", 
            "givenName": "Miki", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kitasato Institute Hospital", 
              "id": "https://www.grid.ac/institutes/grid.415395.f", 
              "name": [
                "Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Toyonaga", 
            "givenName": "Takahiko", 
            "id": "sg:person.01341025641.73", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341025641.73"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sapporo Medical University", 
              "id": "https://www.grid.ac/institutes/grid.263171.0", 
              "name": [
                "Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Onodera", 
            "givenName": "Kei", 
            "id": "sg:person.01066421356.35", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066421356.35"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Tokyo", 
              "id": "https://www.grid.ac/institutes/grid.26999.3d", 
              "name": [
                "Department of Surgery, IMSUT Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shinozaki", 
            "givenName": "Masaru", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hirosaki National Hospital", 
              "id": "https://www.grid.ac/institutes/grid.414152.7", 
              "name": [
                "Department of Gastroenterology and Hematology, Hirosaki National Hospital, Hirosaki, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ishiguro", 
            "givenName": "Yoh", 
            "id": "sg:person.0676175406.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676175406.17"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Keio University", 
              "id": "https://www.grid.ac/institutes/grid.26091.3c", 
              "name": [
                "Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mizuno", 
            "givenName": "Shinta", 
            "id": "sg:person.0645310701.39", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645310701.39"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Okayama University", 
              "id": "https://www.grid.ac/institutes/grid.261356.5", 
              "name": [
                "Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Takahara", 
            "givenName": "Masahiro", 
            "id": "sg:person.0667231735.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667231735.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Iwate Medical University", 
              "id": "https://www.grid.ac/institutes/grid.411790.a", 
              "name": [
                "Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yanai", 
            "givenName": "Shunichi", 
            "id": "sg:person.0720776344.29", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720776344.29"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "National Defense Medical College", 
              "id": "https://www.grid.ac/institutes/grid.416614.0", 
              "name": [
                "Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hokari", 
            "givenName": "Ryota", 
            "id": "sg:person.01216365616.30", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216365616.30"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Chiba University", 
              "id": "https://www.grid.ac/institutes/grid.136304.3", 
              "name": [
                "Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakagawa", 
            "givenName": "Tomoo", 
            "id": "sg:person.0625053007.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625053007.94"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Gifu University Hospital", 
              "id": "https://www.grid.ac/institutes/grid.411704.7", 
              "name": [
                "Division of Endscopy, Gifu University Hospital, Gifu, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Araki", 
            "givenName": "Hiroshi", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sapporo Kosei General Hospital", 
              "id": "https://www.grid.ac/institutes/grid.415268.c", 
              "name": [
                "IBD Center, Sapporo-Kosei General Hospital, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Motoya", 
            "givenName": "Satoshi", 
            "id": "sg:person.01233507634.87", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233507634.87"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tohoku University", 
              "id": "https://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, 980-8574, Sendai, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Naito", 
            "givenName": "Takeo", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tohoku University", 
              "id": "https://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, 980-8574, Sendai, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Moroi", 
            "givenName": "Rintaro", 
            "id": "sg:person.01031346114.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031346114.94"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tohoku University", 
              "id": "https://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, 980-8574, Sendai, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shiga", 
            "givenName": "Hisashi", 
            "id": "sg:person.01213707714.59", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213707714.59"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tohoku University", 
              "id": "https://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, 980-8574, Sendai, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Endo", 
            "givenName": "Katsuya", 
            "id": "sg:person.013547252522.01", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013547252522.01"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kitasato Institute Hospital", 
              "id": "https://www.grid.ac/institutes/grid.415395.f", 
              "name": [
                "Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kobayashi", 
            "givenName": "Taku", 
            "id": "sg:person.01061076747.06", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061076747.06"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Keio University", 
              "id": "https://www.grid.ac/institutes/grid.26091.3c", 
              "name": [
                "Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Naganuma", 
            "givenName": "Makoto", 
            "id": "sg:person.0745517601.66", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745517601.66"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Okayama University", 
              "id": "https://www.grid.ac/institutes/grid.261356.5", 
              "name": [
                "Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hiraoka", 
            "givenName": "Sakiko", 
            "id": "sg:person.01142210671.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142210671.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Iwate Medical University", 
              "id": "https://www.grid.ac/institutes/grid.411790.a", 
              "name": [
                "Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matsumoto", 
            "givenName": "Takayuki", 
            "id": "sg:person.012162205442.47", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012162205442.47"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Hyogo College of Medicine", 
              "id": "https://www.grid.ac/institutes/grid.272264.7", 
              "name": [
                "Division of Internal Medicine, Department of Inflammatory Bowel Disease, Hyogo College of Medicine, Nishinomiya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakamura", 
            "givenName": "Shiro", 
            "id": "sg:person.010031712242.89", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010031712242.89"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Sapporo Medical University", 
              "id": "https://www.grid.ac/institutes/grid.263171.0", 
              "name": [
                "Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakase", 
            "givenName": "Hiroshi", 
            "id": "sg:person.01362225512.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362225512.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Kyorin University", 
              "id": "https://www.grid.ac/institutes/grid.411205.3", 
              "name": [
                "The Third Department of Internal Medicine, Kyorin University School of Medicine, Mitaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hisamatsu", 
            "givenName": "Tadakazu", 
            "id": "sg:person.01105530537.55", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105530537.55"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Aichi Medical University", 
              "id": "https://www.grid.ac/institutes/grid.411234.1", 
              "name": [
                "Division of Gastroenterology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sasaki", 
            "givenName": "Makoto", 
            "id": "sg:person.010600641127.08", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010600641127.08"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "name": [
                "Centre for Gastroenterology and Inflammatory Bowel Disease Research, Hamamatsu South Hospital, Hamamatsu, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hanai", 
            "givenName": "Hiroyuki", 
            "id": "sg:person.01160277320.14", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160277320.14"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Shiga University of Medical Science", 
              "id": "https://www.grid.ac/institutes/grid.410827.8", 
              "name": [
                "Department of Gastroenterology, Shiga University of Medical Science, Otsu, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Andoh", 
            "givenName": "Akira", 
            "id": "sg:person.01075512433.93", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075512433.93"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tohoku University", 
              "id": "https://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nagasaki", 
            "givenName": "Masao", 
            "id": "sg:person.01126167006.24", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126167006.24"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tohoku University", 
              "id": "https://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Health Administration Center, Center for the Advancement of Higher Education, Tohoku University, Sendai, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kinouchi", 
            "givenName": "Yoshitaka", 
            "id": "sg:person.01145574514.32", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145574514.32"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tohoku University", 
              "id": "https://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, 980-8574, Sendai, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shimosegawa", 
            "givenName": "Tooru", 
            "id": "sg:person.01255535707.76", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255535707.76"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Tohoku University", 
              "id": "https://www.grid.ac/institutes/grid.69566.3a", 
              "name": [
                "Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, 980-8574, Sendai, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Masamune", 
            "givenName": "Atsushi", 
            "id": "sg:person.01366123207.25", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366123207.25"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Toho University", 
              "id": "https://www.grid.ac/institutes/grid.265050.4", 
              "name": [
                "Department of Internal Medicine, Toho University Sakura Medical Center, Sakura, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Suzuki", 
            "givenName": "Yasuo", 
            "type": "Person"
          }, 
          {
            "familyName": "for the MENDEL study group", 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s00535-010-0248-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001357550", 
              "https://doi.org/10.1007/s00535-010-0248-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00535-010-0248-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001357550", 
              "https://doi.org/10.1007/s00535-010-0248-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00535-008-2307-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008836843", 
              "https://doi.org/10.1007/s00535-008-2307-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00535-008-2307-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008836843", 
              "https://doi.org/10.1007/s00535-008-2307-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2188/jea.je20150268", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009051532"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2011.64", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011946124", 
              "https://doi.org/10.1038/ajg.2011.64"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ajg.2011.64", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011946124", 
              "https://doi.org/10.1038/ajg.2011.64"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3508", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1013931386", 
              "https://doi.org/10.1038/ng.3508"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/jcp.21372", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016216030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1053/j.gastro.2013.10.052", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023441853"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1440-1746.2009.05917.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024668275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1111/j.1440-1746.2009.05917.x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024668275"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1159/000236023", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1027576410"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ncomms9018", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029523624", 
              "https://doi.org/10.1038/ncomms9018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/md.0000000000001513", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031552648"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/md.0000000000001513", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1031552648"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/jhg.2015.68", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032184954", 
              "https://doi.org/10.1038/jhg.2015.68"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3679", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1034000276", 
              "https://doi.org/10.1038/ng.3679"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/bioinformatics/btq419", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036490983"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3093", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037861909", 
              "https://doi.org/10.1038/ng.3093"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3093", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037861909", 
              "https://doi.org/10.1038/ng.3093"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3093", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037861909", 
              "https://doi.org/10.1038/ng.3093"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/s13742-015-0047-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037894462", 
              "https://doi.org/10.1186/s13742-015-0047-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.2169/internalmedicine.47.1268", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038778895"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1371/journal.pgen.1000529", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043446290"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/tpj.2015.43", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047288958", 
              "https://doi.org/10.1038/tpj.2015.43"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ng.3060", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051527727", 
              "https://doi.org/10.1038/ng.3060"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00535-003-1139-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052421926", 
              "https://doi.org/10.1007/s00535-003-1139-2"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1056/nejmoa0904492", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053418450"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1136/gutjnl-2016-311921", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1062813734"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.can-16-0584", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063216184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.3748/wjg.v20.i16.4712", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1071370646"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077171150", 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/tpj.2017.12", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084904738", 
              "https://doi.org/10.1038/tpj.2017.12"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/tpj.2017.12", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1084904738", 
              "https://doi.org/10.1038/tpj.2017.12"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mib.0000000000001148", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085744987"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1097/mib.0000000000001148", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1085744987"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.5217/ir.2017.15.3.328", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1086143759"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1182/blood-2017-05-782383", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1090390263"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00535-018-1439-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1100940665", 
              "https://doi.org/10.1007/s00535-018-1439-1"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2018-09", 
        "datePublishedReg": "2018-09-01", 
        "description": "BACKGROUND: Despite NUDT15 variants showing significant association with thiopurine-induced adverse events (AEs) in Asians, it remains unclear which variants of NUDT15 or whether additional genetic variants should be tested to predict AEs. To clarify the best pharmacogenetic test to be used clinically, we performed association studies of NUDT15 variants and haplotypes with AEs, genome-wide association study (GWAS) to discover additional variants, and ROC analysis to select the model to predict severe AEs.\nMETHODS: Overall, 2630 patients with inflammatory bowel disease (IBD) were enrolled and genotyped for NUDT15 codon 139; 1291 patients were treated with thiopurines. diplotypes were analyzed in 970 patients, and GWASs of AEs were performed with 1221 patients using population-optimized genotyping array and imputation.\nRESULTS: We confirmed the association of NUDT15 p.Arg139Cys with leukopenia and alopecia (p\u2009=\u20092.20E-63, 1.32E-69, OR\u2009=\u20096.59, 12.1, respectively), and found a novel association with digestive symptoms (p\u2009=\u20096.39E-04, OR\u2009=\u20091.89). Time to leukopenia was significantly shorter, and when leukopenia was diagnosed, thiopurine doses were significantly lower in Arg/Cys and Cys/Cys than in Arg/Arg. In GWASs, no additional variants were found to be associated with thiopurine-induced AEs. Despite strong correlation of leukopenia frequency with estimated enzyme activities based on the diplotypes (r2\u2009=\u20090.926, p\u2009=\u20090.0087), there were no significant differences in the AUCs of diplotypes from those of codon 139 to predict severe AEs (AUC\u2009=\u20090.916, 0.921, for acute severe leukopenia, AUC\u2009=\u20090.990, 0.991, for severe alopecia, respectively).\nCONCLUSIONS: Genotyping of NUDT15 codon 139 was sufficient to predict acute severe leukopenia and alopecia in Japanese patients with IBD.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s00535-018-1486-7", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1009747", 
            "issn": [
              "0944-1174", 
              "1435-5922"
            ], 
            "name": "Journal of Gastroenterology", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "9", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "53"
          }
        ], 
        "name": "NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study", 
        "pagination": "1065-1078", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "2ca026022586b4db029862f2ef2ae2476324d9665a91fa57591148364ee53cdb"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "29923122"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "9430794"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00535-018-1486-7"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1104986865"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00535-018-1486-7", 
          "https://app.dimensions.ai/details/publication/pub.1104986865"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T12:40", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000363_0000000363/records_70049_00000002.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://link.springer.com/10.1007%2Fs00535-018-1486-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00535-018-1486-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00535-018-1486-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00535-018-1486-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00535-018-1486-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    496 TRIPLES      21 PREDICATES      60 URIs      21 LITERALS      9 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00535-018-1486-7 schema:about anzsrc-for:11
    2 anzsrc-for:1103
    3 schema:author N2af615aa897a42ea9427f141791dbde7
    4 schema:citation sg:pub.10.1007/s00535-003-1139-2
    5 sg:pub.10.1007/s00535-008-2307-1
    6 sg:pub.10.1007/s00535-010-0248-y
    7 sg:pub.10.1007/s00535-018-1439-1
    8 sg:pub.10.1038/ajg.2011.64
    9 sg:pub.10.1038/jhg.2015.68
    10 sg:pub.10.1038/ncomms9018
    11 sg:pub.10.1038/ng.3060
    12 sg:pub.10.1038/ng.3093
    13 sg:pub.10.1038/ng.3508
    14 sg:pub.10.1038/ng.3679
    15 sg:pub.10.1038/tpj.2015.43
    16 sg:pub.10.1038/tpj.2017.12
    17 sg:pub.10.1186/s13742-015-0047-8
    18 https://app.dimensions.ai/details/publication/pub.1077171150
    19 https://doi.org/10.1002/jcp.21372
    20 https://doi.org/10.1053/j.gastro.2013.10.052
    21 https://doi.org/10.1056/nejmoa0904492
    22 https://doi.org/10.1093/bioinformatics/btq419
    23 https://doi.org/10.1097/md.0000000000001513
    24 https://doi.org/10.1097/mib.0000000000001148
    25 https://doi.org/10.1111/j.1440-1746.2009.05917.x
    26 https://doi.org/10.1136/gutjnl-2016-311921
    27 https://doi.org/10.1158/0008-5472.can-16-0584
    28 https://doi.org/10.1159/000236023
    29 https://doi.org/10.1182/blood-2017-05-782383
    30 https://doi.org/10.1371/journal.pgen.1000529
    31 https://doi.org/10.2169/internalmedicine.47.1268
    32 https://doi.org/10.2188/jea.je20150268
    33 https://doi.org/10.3748/wjg.v20.i16.4712
    34 https://doi.org/10.5217/ir.2017.15.3.328
    35 schema:datePublished 2018-09
    36 schema:datePublishedReg 2018-09-01
    37 schema:description BACKGROUND: Despite NUDT15 variants showing significant association with thiopurine-induced adverse events (AEs) in Asians, it remains unclear which variants of NUDT15 or whether additional genetic variants should be tested to predict AEs. To clarify the best pharmacogenetic test to be used clinically, we performed association studies of NUDT15 variants and haplotypes with AEs, genome-wide association study (GWAS) to discover additional variants, and ROC analysis to select the model to predict severe AEs. METHODS: Overall, 2630 patients with inflammatory bowel disease (IBD) were enrolled and genotyped for NUDT15 codon 139; 1291 patients were treated with thiopurines. diplotypes were analyzed in 970 patients, and GWASs of AEs were performed with 1221 patients using population-optimized genotyping array and imputation. RESULTS: We confirmed the association of NUDT15 p.Arg139Cys with leukopenia and alopecia (p = 2.20E-63, 1.32E-69, OR = 6.59, 12.1, respectively), and found a novel association with digestive symptoms (p = 6.39E-04, OR = 1.89). Time to leukopenia was significantly shorter, and when leukopenia was diagnosed, thiopurine doses were significantly lower in Arg/Cys and Cys/Cys than in Arg/Arg. In GWASs, no additional variants were found to be associated with thiopurine-induced AEs. Despite strong correlation of leukopenia frequency with estimated enzyme activities based on the diplotypes (r2 = 0.926, p = 0.0087), there were no significant differences in the AUCs of diplotypes from those of codon 139 to predict severe AEs (AUC = 0.916, 0.921, for acute severe leukopenia, AUC = 0.990, 0.991, for severe alopecia, respectively). CONCLUSIONS: Genotyping of NUDT15 codon 139 was sufficient to predict acute severe leukopenia and alopecia in Japanese patients with IBD.
    38 schema:genre research_article
    39 schema:inLanguage en
    40 schema:isAccessibleForFree true
    41 schema:isPartOf N2ffdc1d4151d4f6caf6d0aa01fc80333
    42 Nfe206c904f7a4f2591bf078f5475898a
    43 sg:journal.1009747
    44 schema:name NUDT15 codon 139 is the best pharmacogenetic marker for predicting thiopurine-induced severe adverse events in Japanese patients with inflammatory bowel disease: a multicenter study
    45 schema:pagination 1065-1078
    46 schema:productId N06c828ead3304e3db759c7f467e1de9f
    47 N951f98cfd94f482289562ad8a4c6a964
    48 Nba1e6145918d42ab9bb0388ff4d20a94
    49 Nc8be4bc862054008a5ba7494fb06fb97
    50 Ncf3557d254f94dde85af21cbab15dcd7
    51 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104986865
    52 https://doi.org/10.1007/s00535-018-1486-7
    53 schema:sdDatePublished 2019-04-11T12:40
    54 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    55 schema:sdPublisher N0df775b1a56c47df863d480195428b73
    56 schema:url http://link.springer.com/10.1007%2Fs00535-018-1486-7
    57 sgo:license sg:explorer/license/
    58 sgo:sdDataset articles
    59 rdf:type schema:ScholarlyArticle
    60 N06c828ead3304e3db759c7f467e1de9f schema:name doi
    61 schema:value 10.1007/s00535-018-1486-7
    62 rdf:type schema:PropertyValue
    63 N0798f155d93645a39a2bea5ea69ac7f7 rdf:first N9c5b4a945bf94bcda7c1cbe06cb14189
    64 rdf:rest Nad8302aa4b5346049009b08a7f30abbe
    65 N0c6fdef0267d4bda9aa7a94bd6035602 rdf:first sg:person.0745517601.66
    66 rdf:rest Ne19da27712ef4ad585d00c91c1dcf7f9
    67 N0d83845339864474ac3ba8651d186ce5 rdf:first sg:person.012740104303.26
    68 rdf:rest N5829077fb4a745a9a908dc4e1a793b5c
    69 N0df775b1a56c47df863d480195428b73 schema:name Springer Nature - SN SciGraph project
    70 rdf:type schema:Organization
    71 N164e70db362048119f0cc02a07ba9033 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
    72 schema:familyName Shinozaki
    73 schema:givenName Masaru
    74 rdf:type schema:Person
    75 N1871bbbaec8149ceb75a7ec9e5a02184 rdf:first sg:person.010600641127.08
    76 rdf:rest N310ba502fbfb4033b4ddcf55e54d3e07
    77 N1f11c6527f07411c913767f5a565eeda rdf:first Nd712ca694b7b4b44b3e2aefd26ece366
    78 rdf:rest N0798f155d93645a39a2bea5ea69ac7f7
    79 N2403a862260e4d76b6743a9f5c21b5ae rdf:first sg:person.012162205442.47
    80 rdf:rest Nfaae9773e8624be7aafd687a7af03ebc
    81 N2af615aa897a42ea9427f141791dbde7 rdf:first sg:person.01262023114.94
    82 rdf:rest N2d132a97908c4344b62f267d61faed26
    83 N2cbb9dd83589497cb725bdb2341f5726 rdf:first sg:person.013547252522.01
    84 rdf:rest Ne7570cb250c54b76a9b33f70db1b48d0
    85 N2d132a97908c4344b62f267d61faed26 rdf:first sg:person.01247410770.79
    86 rdf:rest N57ada8f549ca47d2a57fef8b0bc1d39f
    87 N2ffdc1d4151d4f6caf6d0aa01fc80333 schema:issueNumber 9
    88 rdf:type schema:PublicationIssue
    89 N310ba502fbfb4033b4ddcf55e54d3e07 rdf:first sg:person.01160277320.14
    90 rdf:rest Ne796083762a147ce965f26d7c37ad620
    91 N338064c305954a6e9fee8ea71afc3183 rdf:first sg:person.01213707714.59
    92 rdf:rest N2cbb9dd83589497cb725bdb2341f5726
    93 N33b41419b141403a9367d5e83164ed29 schema:affiliation https://www.grid.ac/institutes/grid.265050.4
    94 schema:familyName Suzuki
    95 schema:givenName Yasuo
    96 rdf:type schema:Person
    97 N3a87204a162d43b4ab1a22242036ea87 rdf:first sg:person.01362225512.44
    98 rdf:rest N9d7947eb74284b5e887ccc7f9adea514
    99 N41877da6f74d4d61b06911b908e925ba rdf:first sg:person.01216365616.30
    100 rdf:rest N964cf4ee9f124f1ab3f2680a4fb78307
    101 N57ada8f549ca47d2a57fef8b0bc1d39f rdf:first N5e7bcdf2f6ea48d48d81aa5ff66e38f3
    102 rdf:rest N0d83845339864474ac3ba8651d186ce5
    103 N5829077fb4a745a9a908dc4e1a793b5c rdf:first sg:person.01307150160.38
    104 rdf:rest N88f8d4c8d5ae483bbc92553aeaff9670
    105 N5e7bcdf2f6ea48d48d81aa5ff66e38f3 schema:affiliation https://www.grid.ac/institutes/grid.69566.3a
    106 schema:familyName Okamoto
    107 schema:givenName Daisuke
    108 rdf:type schema:Person
    109 N5ec3c6da193e4a83883fe0b21cd5e202 rdf:first Nebdf85317ec74b53a423aa3d07f95cb4
    110 rdf:rest N1f11c6527f07411c913767f5a565eeda
    111 N601121481dae434ea8fc7e19683f9ccd schema:familyName for the MENDEL study group
    112 rdf:type schema:Person
    113 N61619f9256304076a707f9218d5ac70b rdf:first sg:person.0667231735.66
    114 rdf:rest N99339163adbf491dbdf26d803e7789d4
    115 N64626c1af50d474690e8767a92752707 schema:affiliation https://www.grid.ac/institutes/grid.69566.3a
    116 schema:familyName Naito
    117 schema:givenName Takeo
    118 rdf:type schema:Person
    119 N6ec30c9487514c50985973846de1060f rdf:first sg:person.01366123207.25
    120 rdf:rest N9491a9ef264043e2b2d391a880b7aaac
    121 N7ce83aa73e3342b28cc511fb46be21f2 schema:name Centre for Gastroenterology and Inflammatory Bowel Disease Research, Hamamatsu South Hospital, Hamamatsu, Japan
    122 rdf:type schema:Organization
    123 N88f8d4c8d5ae483bbc92553aeaff9670 rdf:first sg:person.015750664004.19
    124 rdf:rest N5ec3c6da193e4a83883fe0b21cd5e202
    125 N8f4c00e492184d8d975380a3ea0f006e rdf:first sg:person.01255535707.76
    126 rdf:rest N6ec30c9487514c50985973846de1060f
    127 N9491a9ef264043e2b2d391a880b7aaac rdf:first N33b41419b141403a9367d5e83164ed29
    128 rdf:rest Nb64172e360a1452e9e7b33a4a8fb24cf
    129 N951f98cfd94f482289562ad8a4c6a964 schema:name dimensions_id
    130 schema:value pub.1104986865
    131 rdf:type schema:PropertyValue
    132 N964cf4ee9f124f1ab3f2680a4fb78307 rdf:first sg:person.0625053007.94
    133 rdf:rest Nc4395ca612264d8eb76de89ac7a2892c
    134 N99339163adbf491dbdf26d803e7789d4 rdf:first sg:person.0720776344.29
    135 rdf:rest N41877da6f74d4d61b06911b908e925ba
    136 N9c5b4a945bf94bcda7c1cbe06cb14189 schema:affiliation https://www.grid.ac/institutes/grid.411205.3
    137 schema:familyName Miura
    138 schema:givenName Miki
    139 rdf:type schema:Person
    140 N9d7947eb74284b5e887ccc7f9adea514 rdf:first sg:person.01105530537.55
    141 rdf:rest N1871bbbaec8149ceb75a7ec9e5a02184
    142 N9e03d7d094d64fdb85685b66d5d368ee rdf:first N64626c1af50d474690e8767a92752707
    143 rdf:rest Nf6a23c3f1f4349a99e46043950f30b36
    144 Nad8302aa4b5346049009b08a7f30abbe rdf:first sg:person.01341025641.73
    145 rdf:rest Nad9a777af6224338b753014938c69b7d
    146 Nad9a777af6224338b753014938c69b7d rdf:first sg:person.01066421356.35
    147 rdf:rest Nc0ef8106fd244e6291f0cee138b4eb6d
    148 Naece374c10dc4c418f95557bd376aab8 rdf:first sg:person.0645310701.39
    149 rdf:rest N61619f9256304076a707f9218d5ac70b
    150 Nb64172e360a1452e9e7b33a4a8fb24cf rdf:first N601121481dae434ea8fc7e19683f9ccd
    151 rdf:rest rdf:nil
    152 Nba1e6145918d42ab9bb0388ff4d20a94 schema:name pubmed_id
    153 schema:value 29923122
    154 rdf:type schema:PropertyValue
    155 Nbdd5da71bef94186b371e23711b9508c schema:affiliation https://www.grid.ac/institutes/grid.411704.7
    156 schema:familyName Araki
    157 schema:givenName Hiroshi
    158 rdf:type schema:Person
    159 Nbf8df86817c343379617ab7e3e4f602d schema:name Centre for Gastroenterology and Inflammatory Bowel Disease Research, Hamamatsu South Hospital, Hamamatsu, Japan
    160 rdf:type schema:Organization
    161 Nc0ef8106fd244e6291f0cee138b4eb6d rdf:first N164e70db362048119f0cc02a07ba9033
    162 rdf:rest Nf579e0f2028949758d9e62a8b56eb4c4
    163 Nc4395ca612264d8eb76de89ac7a2892c rdf:first Nbdd5da71bef94186b371e23711b9508c
    164 rdf:rest Nd7c72de7bbfb448b95525ed8e2f10c88
    165 Nc8be4bc862054008a5ba7494fb06fb97 schema:name nlm_unique_id
    166 schema:value 9430794
    167 rdf:type schema:PropertyValue
    168 Ncf3557d254f94dde85af21cbab15dcd7 schema:name readcube_id
    169 schema:value 2ca026022586b4db029862f2ef2ae2476324d9665a91fa57591148364ee53cdb
    170 rdf:type schema:PropertyValue
    171 Nd712ca694b7b4b44b3e2aefd26ece366 schema:affiliation https://www.grid.ac/institutes/grid.411234.1
    172 schema:familyName Nakagawa
    173 schema:givenName Shoko
    174 rdf:type schema:Person
    175 Nd7c72de7bbfb448b95525ed8e2f10c88 rdf:first sg:person.01233507634.87
    176 rdf:rest N9e03d7d094d64fdb85685b66d5d368ee
    177 Ne19da27712ef4ad585d00c91c1dcf7f9 rdf:first sg:person.01142210671.26
    178 rdf:rest N2403a862260e4d76b6743a9f5c21b5ae
    179 Ne7570cb250c54b76a9b33f70db1b48d0 rdf:first sg:person.01061076747.06
    180 rdf:rest N0c6fdef0267d4bda9aa7a94bd6035602
    181 Ne796083762a147ce965f26d7c37ad620 rdf:first sg:person.01075512433.93
    182 rdf:rest Nefa75b21193e4a279026bfc14a30418c
    183 Neb7f6db5351143d89825737b4efe29cc rdf:first sg:person.01145574514.32
    184 rdf:rest N8f4c00e492184d8d975380a3ea0f006e
    185 Nebdf85317ec74b53a423aa3d07f95cb4 schema:affiliation https://www.grid.ac/institutes/grid.410827.8
    186 schema:familyName Nishida
    187 schema:givenName Atsushi
    188 rdf:type schema:Person
    189 Nefa75b21193e4a279026bfc14a30418c rdf:first sg:person.01126167006.24
    190 rdf:rest Neb7f6db5351143d89825737b4efe29cc
    191 Nf579e0f2028949758d9e62a8b56eb4c4 rdf:first sg:person.0676175406.17
    192 rdf:rest Naece374c10dc4c418f95557bd376aab8
    193 Nf6a23c3f1f4349a99e46043950f30b36 rdf:first sg:person.01031346114.94
    194 rdf:rest N338064c305954a6e9fee8ea71afc3183
    195 Nfaae9773e8624be7aafd687a7af03ebc rdf:first sg:person.010031712242.89
    196 rdf:rest N3a87204a162d43b4ab1a22242036ea87
    197 Nfe206c904f7a4f2591bf078f5475898a schema:volumeNumber 53
    198 rdf:type schema:PublicationVolume
    199 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    200 schema:name Medical and Health Sciences
    201 rdf:type schema:DefinedTerm
    202 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
    203 schema:name Clinical Sciences
    204 rdf:type schema:DefinedTerm
    205 sg:journal.1009747 schema:issn 0944-1174
    206 1435-5922
    207 schema:name Journal of Gastroenterology
    208 rdf:type schema:Periodical
    209 sg:person.010031712242.89 schema:affiliation https://www.grid.ac/institutes/grid.272264.7
    210 schema:familyName Nakamura
    211 schema:givenName Shiro
    212 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010031712242.89
    213 rdf:type schema:Person
    214 sg:person.01031346114.94 schema:affiliation https://www.grid.ac/institutes/grid.69566.3a
    215 schema:familyName Moroi
    216 schema:givenName Rintaro
    217 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031346114.94
    218 rdf:type schema:Person
    219 sg:person.010600641127.08 schema:affiliation https://www.grid.ac/institutes/grid.411234.1
    220 schema:familyName Sasaki
    221 schema:givenName Makoto
    222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010600641127.08
    223 rdf:type schema:Person
    224 sg:person.01061076747.06 schema:affiliation https://www.grid.ac/institutes/grid.415395.f
    225 schema:familyName Kobayashi
    226 schema:givenName Taku
    227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01061076747.06
    228 rdf:type schema:Person
    229 sg:person.01066421356.35 schema:affiliation https://www.grid.ac/institutes/grid.263171.0
    230 schema:familyName Onodera
    231 schema:givenName Kei
    232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01066421356.35
    233 rdf:type schema:Person
    234 sg:person.01075512433.93 schema:affiliation https://www.grid.ac/institutes/grid.410827.8
    235 schema:familyName Andoh
    236 schema:givenName Akira
    237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01075512433.93
    238 rdf:type schema:Person
    239 sg:person.01105530537.55 schema:affiliation https://www.grid.ac/institutes/grid.411205.3
    240 schema:familyName Hisamatsu
    241 schema:givenName Tadakazu
    242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01105530537.55
    243 rdf:type schema:Person
    244 sg:person.01126167006.24 schema:affiliation https://www.grid.ac/institutes/grid.69566.3a
    245 schema:familyName Nagasaki
    246 schema:givenName Masao
    247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126167006.24
    248 rdf:type schema:Person
    249 sg:person.01142210671.26 schema:affiliation https://www.grid.ac/institutes/grid.261356.5
    250 schema:familyName Hiraoka
    251 schema:givenName Sakiko
    252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01142210671.26
    253 rdf:type schema:Person
    254 sg:person.01145574514.32 schema:affiliation https://www.grid.ac/institutes/grid.69566.3a
    255 schema:familyName Kinouchi
    256 schema:givenName Yoshitaka
    257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145574514.32
    258 rdf:type schema:Person
    259 sg:person.01160277320.14 schema:affiliation Nbf8df86817c343379617ab7e3e4f602d
    260 schema:familyName Hanai
    261 schema:givenName Hiroyuki
    262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01160277320.14
    263 rdf:type schema:Person
    264 sg:person.01213707714.59 schema:affiliation https://www.grid.ac/institutes/grid.69566.3a
    265 schema:familyName Shiga
    266 schema:givenName Hisashi
    267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213707714.59
    268 rdf:type schema:Person
    269 sg:person.012162205442.47 schema:affiliation https://www.grid.ac/institutes/grid.411790.a
    270 schema:familyName Matsumoto
    271 schema:givenName Takayuki
    272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012162205442.47
    273 rdf:type schema:Person
    274 sg:person.01216365616.30 schema:affiliation https://www.grid.ac/institutes/grid.416614.0
    275 schema:familyName Hokari
    276 schema:givenName Ryota
    277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216365616.30
    278 rdf:type schema:Person
    279 sg:person.01233507634.87 schema:affiliation https://www.grid.ac/institutes/grid.415268.c
    280 schema:familyName Motoya
    281 schema:givenName Satoshi
    282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233507634.87
    283 rdf:type schema:Person
    284 sg:person.01247410770.79 schema:affiliation https://www.grid.ac/institutes/grid.26999.3d
    285 schema:familyName Kawai
    286 schema:givenName Yosuke
    287 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247410770.79
    288 rdf:type schema:Person
    289 sg:person.01255535707.76 schema:affiliation https://www.grid.ac/institutes/grid.69566.3a
    290 schema:familyName Shimosegawa
    291 schema:givenName Tooru
    292 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01255535707.76
    293 rdf:type schema:Person
    294 sg:person.01262023114.94 schema:affiliation https://www.grid.ac/institutes/grid.69566.3a
    295 schema:familyName Kakuta
    296 schema:givenName Yoichi
    297 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01262023114.94
    298 rdf:type schema:Person
    299 sg:person.012740104303.26 schema:affiliation https://www.grid.ac/institutes/grid.272264.7
    300 schema:familyName Takagawa
    301 schema:givenName Tetsuya
    302 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012740104303.26
    303 rdf:type schema:Person
    304 sg:person.01307150160.38 schema:affiliation N7ce83aa73e3342b28cc511fb46be21f2
    305 schema:familyName Ikeya
    306 schema:givenName Kentaro
    307 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01307150160.38
    308 rdf:type schema:Person
    309 sg:person.01341025641.73 schema:affiliation https://www.grid.ac/institutes/grid.415395.f
    310 schema:familyName Toyonaga
    311 schema:givenName Takahiko
    312 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01341025641.73
    313 rdf:type schema:Person
    314 sg:person.013547252522.01 schema:affiliation https://www.grid.ac/institutes/grid.69566.3a
    315 schema:familyName Endo
    316 schema:givenName Katsuya
    317 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013547252522.01
    318 rdf:type schema:Person
    319 sg:person.01362225512.44 schema:affiliation https://www.grid.ac/institutes/grid.263171.0
    320 schema:familyName Nakase
    321 schema:givenName Hiroshi
    322 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01362225512.44
    323 rdf:type schema:Person
    324 sg:person.01366123207.25 schema:affiliation https://www.grid.ac/institutes/grid.69566.3a
    325 schema:familyName Masamune
    326 schema:givenName Atsushi
    327 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01366123207.25
    328 rdf:type schema:Person
    329 sg:person.015750664004.19 schema:affiliation https://www.grid.ac/institutes/grid.257016.7
    330 schema:familyName Sakuraba
    331 schema:givenName Hirotake
    332 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015750664004.19
    333 rdf:type schema:Person
    334 sg:person.0625053007.94 schema:affiliation https://www.grid.ac/institutes/grid.136304.3
    335 schema:familyName Nakagawa
    336 schema:givenName Tomoo
    337 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625053007.94
    338 rdf:type schema:Person
    339 sg:person.0645310701.39 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
    340 schema:familyName Mizuno
    341 schema:givenName Shinta
    342 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0645310701.39
    343 rdf:type schema:Person
    344 sg:person.0667231735.66 schema:affiliation https://www.grid.ac/institutes/grid.261356.5
    345 schema:familyName Takahara
    346 schema:givenName Masahiro
    347 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667231735.66
    348 rdf:type schema:Person
    349 sg:person.0676175406.17 schema:affiliation https://www.grid.ac/institutes/grid.414152.7
    350 schema:familyName Ishiguro
    351 schema:givenName Yoh
    352 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0676175406.17
    353 rdf:type schema:Person
    354 sg:person.0720776344.29 schema:affiliation https://www.grid.ac/institutes/grid.411790.a
    355 schema:familyName Yanai
    356 schema:givenName Shunichi
    357 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0720776344.29
    358 rdf:type schema:Person
    359 sg:person.0745517601.66 schema:affiliation https://www.grid.ac/institutes/grid.26091.3c
    360 schema:familyName Naganuma
    361 schema:givenName Makoto
    362 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745517601.66
    363 rdf:type schema:Person
    364 sg:pub.10.1007/s00535-003-1139-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052421926
    365 https://doi.org/10.1007/s00535-003-1139-2
    366 rdf:type schema:CreativeWork
    367 sg:pub.10.1007/s00535-008-2307-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008836843
    368 https://doi.org/10.1007/s00535-008-2307-1
    369 rdf:type schema:CreativeWork
    370 sg:pub.10.1007/s00535-010-0248-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1001357550
    371 https://doi.org/10.1007/s00535-010-0248-y
    372 rdf:type schema:CreativeWork
    373 sg:pub.10.1007/s00535-018-1439-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100940665
    374 https://doi.org/10.1007/s00535-018-1439-1
    375 rdf:type schema:CreativeWork
    376 sg:pub.10.1038/ajg.2011.64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011946124
    377 https://doi.org/10.1038/ajg.2011.64
    378 rdf:type schema:CreativeWork
    379 sg:pub.10.1038/jhg.2015.68 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032184954
    380 https://doi.org/10.1038/jhg.2015.68
    381 rdf:type schema:CreativeWork
    382 sg:pub.10.1038/ncomms9018 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029523624
    383 https://doi.org/10.1038/ncomms9018
    384 rdf:type schema:CreativeWork
    385 sg:pub.10.1038/ng.3060 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051527727
    386 https://doi.org/10.1038/ng.3060
    387 rdf:type schema:CreativeWork
    388 sg:pub.10.1038/ng.3093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037861909
    389 https://doi.org/10.1038/ng.3093
    390 rdf:type schema:CreativeWork
    391 sg:pub.10.1038/ng.3508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013931386
    392 https://doi.org/10.1038/ng.3508
    393 rdf:type schema:CreativeWork
    394 sg:pub.10.1038/ng.3679 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034000276
    395 https://doi.org/10.1038/ng.3679
    396 rdf:type schema:CreativeWork
    397 sg:pub.10.1038/tpj.2015.43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047288958
    398 https://doi.org/10.1038/tpj.2015.43
    399 rdf:type schema:CreativeWork
    400 sg:pub.10.1038/tpj.2017.12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084904738
    401 https://doi.org/10.1038/tpj.2017.12
    402 rdf:type schema:CreativeWork
    403 sg:pub.10.1186/s13742-015-0047-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037894462
    404 https://doi.org/10.1186/s13742-015-0047-8
    405 rdf:type schema:CreativeWork
    406 https://app.dimensions.ai/details/publication/pub.1077171150 schema:CreativeWork
    407 https://doi.org/10.1002/jcp.21372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016216030
    408 rdf:type schema:CreativeWork
    409 https://doi.org/10.1053/j.gastro.2013.10.052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023441853
    410 rdf:type schema:CreativeWork
    411 https://doi.org/10.1056/nejmoa0904492 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053418450
    412 rdf:type schema:CreativeWork
    413 https://doi.org/10.1093/bioinformatics/btq419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036490983
    414 rdf:type schema:CreativeWork
    415 https://doi.org/10.1097/md.0000000000001513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031552648
    416 rdf:type schema:CreativeWork
    417 https://doi.org/10.1097/mib.0000000000001148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085744987
    418 rdf:type schema:CreativeWork
    419 https://doi.org/10.1111/j.1440-1746.2009.05917.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1024668275
    420 rdf:type schema:CreativeWork
    421 https://doi.org/10.1136/gutjnl-2016-311921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062813734
    422 rdf:type schema:CreativeWork
    423 https://doi.org/10.1158/0008-5472.can-16-0584 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063216184
    424 rdf:type schema:CreativeWork
    425 https://doi.org/10.1159/000236023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027576410
    426 rdf:type schema:CreativeWork
    427 https://doi.org/10.1182/blood-2017-05-782383 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090390263
    428 rdf:type schema:CreativeWork
    429 https://doi.org/10.1371/journal.pgen.1000529 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043446290
    430 rdf:type schema:CreativeWork
    431 https://doi.org/10.2169/internalmedicine.47.1268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038778895
    432 rdf:type schema:CreativeWork
    433 https://doi.org/10.2188/jea.je20150268 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009051532
    434 rdf:type schema:CreativeWork
    435 https://doi.org/10.3748/wjg.v20.i16.4712 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071370646
    436 rdf:type schema:CreativeWork
    437 https://doi.org/10.5217/ir.2017.15.3.328 schema:sameAs https://app.dimensions.ai/details/publication/pub.1086143759
    438 rdf:type schema:CreativeWork
    439 https://www.grid.ac/institutes/grid.136304.3 schema:alternateName Chiba University
    440 schema:name Department of Gastroenterology, Graduate School of Medicine, Chiba University, Chiba, Japan
    441 rdf:type schema:Organization
    442 https://www.grid.ac/institutes/grid.257016.7 schema:alternateName Hirosaki University
    443 schema:name Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    444 rdf:type schema:Organization
    445 https://www.grid.ac/institutes/grid.26091.3c schema:alternateName Keio University
    446 schema:name Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    447 rdf:type schema:Organization
    448 https://www.grid.ac/institutes/grid.261356.5 schema:alternateName Okayama University
    449 schema:name Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan
    450 rdf:type schema:Organization
    451 https://www.grid.ac/institutes/grid.263171.0 schema:alternateName Sapporo Medical University
    452 schema:name Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan
    453 rdf:type schema:Organization
    454 https://www.grid.ac/institutes/grid.265050.4 schema:alternateName Toho University
    455 schema:name Department of Internal Medicine, Toho University Sakura Medical Center, Sakura, Japan
    456 rdf:type schema:Organization
    457 https://www.grid.ac/institutes/grid.26999.3d schema:alternateName University of Tokyo
    458 schema:name Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    459 Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
    460 Department of Surgery, IMSUT Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    461 rdf:type schema:Organization
    462 https://www.grid.ac/institutes/grid.272264.7 schema:alternateName Hyogo College of Medicine
    463 schema:name Division of Internal Medicine, Department of Inflammatory Bowel Disease, Hyogo College of Medicine, Nishinomiya, Japan
    464 rdf:type schema:Organization
    465 https://www.grid.ac/institutes/grid.410827.8 schema:alternateName Shiga University of Medical Science
    466 schema:name Department of Gastroenterology, Shiga University of Medical Science, Otsu, Japan
    467 rdf:type schema:Organization
    468 https://www.grid.ac/institutes/grid.411205.3 schema:alternateName Kyorin University
    469 schema:name The Third Department of Internal Medicine, Kyorin University School of Medicine, Mitaka, Japan
    470 rdf:type schema:Organization
    471 https://www.grid.ac/institutes/grid.411234.1 schema:alternateName Aichi Medical University
    472 schema:name Division of Gastroenterology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Japan
    473 rdf:type schema:Organization
    474 https://www.grid.ac/institutes/grid.411704.7 schema:alternateName Gifu University Hospital
    475 schema:name Division of Endscopy, Gifu University Hospital, Gifu, Japan
    476 rdf:type schema:Organization
    477 https://www.grid.ac/institutes/grid.411790.a schema:alternateName Iwate Medical University
    478 schema:name Division of Gastroenterology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka, Japan
    479 rdf:type schema:Organization
    480 https://www.grid.ac/institutes/grid.414152.7 schema:alternateName Hirosaki National Hospital
    481 schema:name Department of Gastroenterology and Hematology, Hirosaki National Hospital, Hirosaki, Japan
    482 rdf:type schema:Organization
    483 https://www.grid.ac/institutes/grid.415268.c schema:alternateName Sapporo Kosei General Hospital
    484 schema:name IBD Center, Sapporo-Kosei General Hospital, Sapporo, Japan
    485 rdf:type schema:Organization
    486 https://www.grid.ac/institutes/grid.415395.f schema:alternateName Kitasato Institute Hospital
    487 schema:name Center for Advanced IBD Research and Treatment, Kitasato University Kitasato Institute Hospital, Tokyo, Japan
    488 rdf:type schema:Organization
    489 https://www.grid.ac/institutes/grid.416614.0 schema:alternateName National Defense Medical College
    490 schema:name Division of Gastroenterology and Hepatology, Department of Internal Medicine, National Defense Medical College, Tokorozawa, Japan
    491 rdf:type schema:Organization
    492 https://www.grid.ac/institutes/grid.69566.3a schema:alternateName Tohoku University
    493 schema:name Department of Integrative Genomics, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
    494 Division of Gastroenterology, Tohoku University Graduate School of Medicine, 1-1 Seiryo, Aoba, 980-8574, Sendai, Japan
    495 Health Administration Center, Center for the Advancement of Higher Education, Tohoku University, Sendai, Japan
    496 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...