The novel cutoff points for the FIB4 index categorized by age increase the diagnostic accuracy in NAFLD: a multi-center study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-11

AUTHORS

Hiroshi Ishiba, Yoshio Sumida, Saiyu Tanaka, Masato Yoneda, Hideyuki Hyogo, Masafumi Ono, Hideki Fujii, Yuichiro Eguchi, Yasuaki Suzuki, Masashi Yoneda, Hirokazu Takahashi, Takashi Nakahara, Yuya Seko, Kojiro Mori, Kazuyuki Kanemasa, Keiji Shimada, Sunsuke Imai, Kento Imajo, Takumi Kawaguchi, Atsushi Nakajima, Kazuaki Chayama, Toshiji Saibara, Toshihide Shima, Kazuma Fujimoto, Takeshi Okanoue, Yoshito Itoh, for the Japan Study Group of Non-Alcoholic Fatty Liver Disease (JSG-NAFLD)

ABSTRACT

BACKGROUND: The FIB4 index is clinically useful, but because its formula includes age, the appropriate cutoff point may differ by age group. Here, new FIB4 index cutoff points were validated using cohort data from 14 hepatology centers in Japan. METHODS: The FIB4 index was determined in biopsy-confirmed NAFLD patients (n = 1050) who were divided into four groups: ≤ 49, 50-59, 60-69, and ≥ 70 years. ROC analysis predicted advanced fibrosis in each age group; low and high cutoff points were defined by a sensitivity and specificity of 90%. The new and conventional cutoffs were compared for detecting advanced fibrosis. RESULTS: The modified low and high cutoff points were 1.05 and 1.21 in ≤ 49 years, 1.24 and 1.96 in 50-59 years, 1.88 and 3.24 in 60-69 years, and 1.95 and 4.56 in ≥ 70 years. In ≥ 60 years, the false-negative rate was increased using the modified high cutoff point, and the high cutoff point was better with the conventional cutoff point. The new proposed low and high cutoff points are 1.05 and 1.21 in ≤ 49 years, 1.24 and 1.96 in 50-59 years, 1.88 and 2.67 in 60-69 years, and 1.95 and 2.67 in ≥ 70 years; these cutoff points improved the accuracy of advanced fibrosis diagnosis. CONCLUSIONS: FIB4 index cutoff points for predicting advanced fibrosis in NAFLD increased with age. Cutoff points modified by age improved the diagnostic accuracy of estimations of advanced liver fibrosis using the FIB4 index. More... »

PAGES

1216-1224

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00535-018-1474-y

DOI

http://dx.doi.org/10.1007/s00535-018-1474-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1103901166

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29744597


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