The profiling of plasma free amino acids and the relationship between serum albumin and plasma-branched chain amino acids in chronic ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-01-27

AUTHORS

Akitoshi Sano, Eiji Kakazu, Tatsuki Morosawa, Jun Inoue, Takayuki Kogure, Masashi Ninomiya, Tomoaki Iwata, Teruyuki Umetsu, Takuya Nakamura, Satoshi Takai, Tooru Shimosegawa

ABSTRACT

BackgroundIt is poorly understood how an imbalance of plasma-free amino acids (PFAAs) occurs and how the imbalance shows an association with the serum albumin (sAlb) level during the progression of chronic liver disease (CLDs). The aim of this study is to elucidate the profiles of PFAAs and the relationship between sAlb and PFAAs in recent patients with CLDs during the progression.MethodsWe retrospectively evaluated the 1569 data of PFAAs data obtained from 908 patients with various CLDs (CHC, CHB. alcoholic, NAFLD/NASH, PBC, AIH, PSC, and cryptogenic). In total, 1140 data of PFAAs could be analyzed in patients with CLDs dependent of their Child–Pugh (CP) score.ResultsVarious imbalances in PFAAs were observed in each CLDs during the progression. Univariate and multivariate analysis revealed that among 24 PFAAs, the level of plasma-branched chain amino acids (pBCAAs) was significantly associated with the CP score, especially the sAlb score, in patients with chronic hepatitis C virus (CHC), NAFLD/NASH and PBC. The correlation coefficient values between sAlb and pBCAAs-to-Tyrosine ratio (BTR) in these patients were 0.53, 0.53 and 0.79, respectively. Interestingly, although the pBCAAs in NAFLD/NASH patients varied even when the sAlb was within the normal range, the pBCAAs tended to be low when the sAlb was below the normal range.ConclusionsAlthough a decrease in the level of pBCAAs was observed during the progression regardless of the CLD etiology, the level of total pBCAAs was independently associated with the sAlb level in the PFAAs of CHC, PBC and NAFLD/NASH. The correlation between sAlb and BTR showed the highest value in PBC patients among the patients with CLDs. A decrease in pBCAAs often occurred in NASH even when the sAlb level was kept in the normal range. More... »

PAGES

978-988

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00535-018-1435-5

DOI

http://dx.doi.org/10.1007/s00535-018-1435-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100679199

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29380062


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28 schema:description BackgroundIt is poorly understood how an imbalance of plasma-free amino acids (PFAAs) occurs and how the imbalance shows an association with the serum albumin (sAlb) level during the progression of chronic liver disease (CLDs). The aim of this study is to elucidate the profiles of PFAAs and the relationship between sAlb and PFAAs in recent patients with CLDs during the progression.MethodsWe retrospectively evaluated the 1569 data of PFAAs data obtained from 908 patients with various CLDs (CHC, CHB. alcoholic, NAFLD/NASH, PBC, AIH, PSC, and cryptogenic). In total, 1140 data of PFAAs could be analyzed in patients with CLDs dependent of their Child–Pugh (CP) score.ResultsVarious imbalances in PFAAs were observed in each CLDs during the progression. Univariate and multivariate analysis revealed that among 24 PFAAs, the level of plasma-branched chain amino acids (pBCAAs) was significantly associated with the CP score, especially the sAlb score, in patients with chronic hepatitis C virus (CHC), NAFLD/NASH and PBC. The correlation coefficient values between sAlb and pBCAAs-to-Tyrosine ratio (BTR) in these patients were 0.53, 0.53 and 0.79, respectively. Interestingly, although the pBCAAs in NAFLD/NASH patients varied even when the sAlb was within the normal range, the pBCAAs tended to be low when the sAlb was below the normal range.ConclusionsAlthough a decrease in the level of pBCAAs was observed during the progression regardless of the CLD etiology, the level of total pBCAAs was independently associated with the sAlb level in the PFAAs of CHC, PBC and NAFLD/NASH. The correlation between sAlb and BTR showed the highest value in PBC patients among the patients with CLDs. A decrease in pBCAAs often occurred in NASH even when the sAlb level was kept in the normal range.
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34 schema:keywords BTR
35 BackgroundIt
36 C virus
37 CLD etiology
38 CP score
39 Child-Pugh score
40 ConclusionsAlthough
41 MethodsWe
42 NAFLD/
43 NAFLD/NASH
44 NASH
45 PBC
46 PBC patients
47 SalB
48 acid
49 aim
50 albumin
51 albumin levels
52 amino acids
53 analysis
54 association
55 chain amino acids
56 chronic hepatitis C virus
57 chronic liver disease
58 coefficient values
59 correlation
60 correlation coefficient values
61 data
62 decrease
63 disease
64 etiology
65 free amino acids
66 hepatitis C virus
67 higher values
68 imbalance
69 levels
70 liver disease
71 normal range
72 patients
73 plasma branched-chain amino acids
74 plasma free amino acids
75 profile
76 profiling
77 progression
78 range
79 ratio
80 recent patients
81 relationship
82 retrospective study
83 sAlb levels
84 scores
85 serum albumin
86 serum albumin level
87 single-center retrospective study
88 study
89 tyrosine ratio
90 values
91 virus
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