A simple scoring system using type IV collagen 7S and aspartate aminotransferase for diagnosing nonalcoholic steatohepatitis and related fibrosis View Full Text


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Article Info

DATE

2018-01

AUTHORS

Takeshi Okanoue, Hayao Ebise, Toshihiro Kai, Masayuki Mizuno, Toshihide Shima, Junji Ichihara, Mikio Aoki

ABSTRACT

BACKGROUND: Recently we reported novel noninvasive scoring systems for diagnosing nonalcoholic steatohepatitis (NASH) and related fibrosis, namely FM-NASH index and FM-fibro index. They are highly accurate, however, they contain some items not widely used in clinical practice and require six or more items to diagnose both NASH and related fibrosis. By focusing on widely used items, we tried to identify convenient markers in common with the both diagnoses. METHODS: To explore the markers for NASH and related fibrosis in nonalcoholic fatty liver disease (NAFLD) patients, we used data of 24 clinical items in our previous report. By logistic regression analysis, we identified items suitable for the both diagnoses. We then evaluated their accuracies by area under the receiver operator characteristic curves (AUROCs) on independent validation data. RESULTS: We identified the combination of type IV collagen 7S and aspartate aminotransferase (AST) as the predictor both for NASH and related fibrosis. We developed a scoring system based on the combination and evaluated the prediction accuracy: the AUROCs for training/validation data sets are 0.857/0.769 for NASH and 0.918/0.842 for NASH-related fibrosis. The former was higher than that of NAFIC score, and the latter was higher than those of existing fibrosis markers: BARD score, FIB-4 index and NAFLD fibrosis score but lower than FM-fibro index. CONCLUSIONS: The scoring system using type IV collagen 7S and AST named CA index can predict both NASH and related fibrosis in NAFLD patients with sufficient accuracy and could be a convenient diagnostic and screening tool for NASH and related fibrosis. The scoring system needs to be validated in independent larger populations from multiple clinical centers. More... »

PAGES

129-139

References to SciGraph publications

  • 2008-06. Validation of the NAFLD Fibrosis Score in a Chinese Population With Low Prevalence of Advanced Fibrosis in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2007-05. Type IV collagen 7s domain is an independent clinical marker of the severity of fibrosis in patients with nonalcoholic steatohepatitis before the cirrhotic stage in JOURNAL OF GASTROENTEROLOGY
  • 2008-12. Evaluation of Alanine Transaminase and Hepatitis B Virus DNA to Predict Liver Cirrhosis in Hepatitis B e Antigen-Negative Chronic Hepatitis B Using Transient Elastography in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2015-04. Evidence-based clinical practice guidelines for nonalcoholic fatty liver disease/nonalcoholic steatohepatitis in JOURNAL OF GASTROENTEROLOGY
  • 2007-09. Usefulness of a Combined Evaluation of the Serum Adiponectin Level, HOMA-IR, and Serum Type IV Collagen 7S Level to Predict the Early Stage of Nonalcoholic Steatohepatitis in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2008-03. The Utility of the “NAFLD Fibrosis Score” in Morbidly Obese Subjects with NAFLD in OBESITY SURGERY
  • 2012-12. Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease population in BMC GASTROENTEROLOGY
  • 2010-12. Validation of the BARD scoring system in Polish patients with nonalcoholic fatty liver disease (NAFLD) in BMC GASTROENTEROLOGY
  • 2011-02. A simple clinical scoring system using ferritin, fasting insulin, and type IV collagen 7S for predicting steatohepatitis in nonalcoholic fatty liver disease in JOURNAL OF GASTROENTEROLOGY
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00535-017-1355-9

    DOI

    http://dx.doi.org/10.1007/s00535-017-1355-9

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1085886279

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28589339


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    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00535-017-1355-9'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00535-017-1355-9'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00535-017-1355-9'

    RDF/XML is a standard XML format for linked data.

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