Validation of serological models for staging and prognostication of HCC in patients from a Japanese nationwide survey View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-02-21

AUTHORS

Hienori Toyoda, Toshifumi Tada, Philip J. Johnson, Namiki Izumi, Masumi Kadoya, Shuichi Kaneko, Norihiro Kokudo, Yonson Ku, Shoji Kubo, Takashi Kumada, Yutaka Matsuyama, Osamu Nakashima, Michiie Sakamoto, Tadatoshi Takayama, Masatoshi Kudo, The Liver Cancer Study Group of Japan

ABSTRACT

BackgroundTwo serology-based scoring models for prognostication of patients with hepatocellular carcinoma (HCC), the BALAD and BALAD-2 models, were applied to a Japanese cohort of a nationwide follow-up survey of HCC. The ability of these models to predict the progression of HCC and the deterioration of liver function and to assess prognosis was evaluated.MethodsBALAD and BALAD-2 scores were calculated in 24,029 patients from a cohort of Japanese nationwide survey based on the serum levels of five markers (bilirubin, albumin, lens culinaris agglutinin-reactive alpha-fetoprotein, alpha-fetoprotein, and des-gamma-carboxy prothrombin) measured at the time of HCC diagnosis. The associations of these scores with the progression of HCC and liver function and with survival rates were analyzed.ResultsThere were good correlations between BALAD and BALAD-2 scores and the progression of HCC and Child–Pugh class. Both scores accurately categorized patients into risk groups with different survival rates. BALAD-2 showed superior discrimination of patient survival compared with the original BALAD.ConclusionsSerology-based scoring models for prognostication, especially the BALAD-2 model, were useful for staging and prognostication of survival in a cohort of Japanese patients with HCC from a nationwide survey. More... »

PAGES

1112-1121

References to SciGraph publications

Journal

TITLE

Journal of Gastroenterology

ISSUE

10

VOLUME

52

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00535-017-1321-6

DOI

http://dx.doi.org/10.1007/s00535-017-1321-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1083855091

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28224228


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26 schema:description BackgroundTwo serology-based scoring models for prognostication of patients with hepatocellular carcinoma (HCC), the BALAD and BALAD-2 models, were applied to a Japanese cohort of a nationwide follow-up survey of HCC. The ability of these models to predict the progression of HCC and the deterioration of liver function and to assess prognosis was evaluated.MethodsBALAD and BALAD-2 scores were calculated in 24,029 patients from a cohort of Japanese nationwide survey based on the serum levels of five markers (bilirubin, albumin, lens culinaris agglutinin-reactive alpha-fetoprotein, alpha-fetoprotein, and des-gamma-carboxy prothrombin) measured at the time of HCC diagnosis. The associations of these scores with the progression of HCC and liver function and with survival rates were analyzed.ResultsThere were good correlations between BALAD and BALAD-2 scores and the progression of HCC and Child–Pugh class. Both scores accurately categorized patients into risk groups with different survival rates. BALAD-2 showed superior discrimination of patient survival compared with the original BALAD.ConclusionsSerology-based scoring models for prognostication, especially the BALAD-2 model, were useful for staging and prognostication of survival in a cohort of Japanese patients with HCC from a nationwide survey.
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33 schema:keywords BALAD-2
34 BALAD-2 models
35 BALAD-2 scores
36 BackgroundTwo serology-based scoring models
37 Balad
38 Child-Pugh class
39 ConclusionsSerology-based scoring models
40 HCC diagnosis
41 Japanese cohort
42 Japanese nationwide survey
43 Japanese patients
44 MethodsBALAD
45 ResultsThere
46 ability
47 association
48 carcinoma
49 class
50 cohort
51 correlation
52 deterioration
53 diagnosis
54 different survival rates
55 discrimination
56 follow
57 function
58 good correlation
59 group
60 hepatocellular carcinoma
61 levels
62 liver function
63 markers
64 model
65 nationwide follow
66 nationwide survey
67 original BALAD
68 patient survival
69 patients
70 prognosis
71 prognostication
72 prognostication of HCC
73 prognostication of patients
74 prognostication of survival
75 progression
76 progression of HCC
77 rate
78 risk groups
79 scores
80 scoring model
81 serological models
82 serology-based scoring models
83 serum levels
84 staging
85 superior discrimination
86 survey
87 survey of HCC
88 survival
89 survival rate
90 time
91 validation
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