Differences in the risk of fatty liver for onset of impaired fasting glucose according to baseline plasma glucose levels View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-06-24

AUTHORS

Teruki Miyake, Masashi Hirooka, Osamu Yoshida, Shinya Furukawa, Teru Kumagi, Mitsuhito Koizumi, Shin Yamamoto, Taira Kuroda, Eiji Arimitsu, Eiji Takeshita, Masanori Abe, Kohichiro Kitai, Bunzo Matsuura, Yoichi Hiasa

ABSTRACT

BackgroundIt remains unclear whether fatty liver is a risk factor for the onset of abnormal glucose tolerance in any patient. The objective of this study was to clarify the relationship between fatty liver and the onset of impaired fasting glucose according to baseline fasting plasma glucose (FPG) levels.MethodsThis community-based longitudinal cohort study included 7,905 adults (3,863 men, 4,042 women; age range, 18–80 years) who had at least two annual checkups between 2003 and 2013. Those with FPG levels ≥110 mg/dl, taking anti-diabetic agents, and/or testing positive for hepatitis B surface antigen or anti-hepatitis C virus antibody were excluded, leaving 7,203 participants eligible for inclusion. All participants were divided into quartiles derived from their FPG levels at baseline. FPG ≥110 mg/dl during the observation period was defined as onset of IFG.ResultsOnset of IFG was found in 7.7 % of men and 2.1 % of women (p < 0.001). After adjusting for age, body mass index, systolic blood pressure, triacylglycerol, high-density lipoprotein cholesterol, uric acid, creatinine, family history of diabetes, alcohol consumption, and current smoking, a positive association was found between fatty liver and the onset of IFG in both sexes with the highest quartile of FPG levels [men: adjusted hazard ratio (aHR) 1.823, 95 % confidence interval (CI) 1.316–2.534, p < 0.001; women: aHR 2.016, 95 % CI 1.117–3.6, p = 0.02].ConclusionsOur results suggest that fatty liver is independently associated with an increased risk of developing IFG in individuals with high FPG. More... »

PAGES

237-244

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00535-016-1234-9

DOI

http://dx.doi.org/10.1007/s00535-016-1234-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042279711

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27342127


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27 schema:description BackgroundIt remains unclear whether fatty liver is a risk factor for the onset of abnormal glucose tolerance in any patient. The objective of this study was to clarify the relationship between fatty liver and the onset of impaired fasting glucose according to baseline fasting plasma glucose (FPG) levels.MethodsThis community-based longitudinal cohort study included 7,905 adults (3,863 men, 4,042 women; age range, 18–80 years) who had at least two annual checkups between 2003 and 2013. Those with FPG levels ≥110 mg/dl, taking anti-diabetic agents, and/or testing positive for hepatitis B surface antigen or anti-hepatitis C virus antibody were excluded, leaving 7,203 participants eligible for inclusion. All participants were divided into quartiles derived from their FPG levels at baseline. FPG ≥110 mg/dl during the observation period was defined as onset of IFG.ResultsOnset of IFG was found in 7.7 % of men and 2.1 % of women (p < 0.001). After adjusting for age, body mass index, systolic blood pressure, triacylglycerol, high-density lipoprotein cholesterol, uric acid, creatinine, family history of diabetes, alcohol consumption, and current smoking, a positive association was found between fatty liver and the onset of IFG in both sexes with the highest quartile of FPG levels [men: adjusted hazard ratio (aHR) 1.823, 95 % confidence interval (CI) 1.316–2.534, p < 0.001; women: aHR 2.016, 95 % CI 1.117–3.6, p = 0.02].ConclusionsOur results suggest that fatty liver is independently associated with an increased risk of developing IFG in individuals with high FPG.
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34 BackgroundIt
35 C virus antibody
36 ConclusionsOur results
37 FPG
38 FPG levels
39 IFG
40 ResultsOnset
41 abnormal glucose tolerance
42 acid
43 adults
44 age
45 agents
46 alcohol consumption
47 annual checkup
48 anti-diabetic agents
49 anti-hepatitis C virus antibody
50 antibodies
51 antigen
52 association
53 baseline
54 baseline plasma glucose levels
55 blood pressure
56 body mass index
57 checkup
58 cholesterol
59 cohort study
60 community-based longitudinal cohort study
61 consumption
62 creatinine
63 current smoking
64 diabetes
65 differences
66 dl
67 factors
68 family history
69 fatty liver
70 glucose
71 glucose levels
72 glucose tolerance
73 hepatitis B surface antigen
74 high-density lipoprotein cholesterol
75 higher FPG
76 highest quartile
77 history
78 inclusion
79 index
80 individuals
81 levels
82 lipoprotein cholesterol
83 liver
84 longitudinal cohort study
85 mass index
86 men
87 objective
88 observation period
89 onset
90 onset of IFG
91 participants
92 patients
93 period
94 plasma glucose levels
95 positive association
96 pressure
97 quartile
98 relationship
99 results
100 risk
101 risk factors
102 sex
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106 systolic blood pressure
107 tolerance
108 triacylglycerols
109 uric acid
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