Evidence-based clinical practice guidelines for gastroesophageal reflux disease 2015 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-06-21

AUTHORS

Katsuhiko Iwakiri, Yoshikazu Kinoshita, Yasuki Habu, Tadayuki Oshima, Noriaki Manabe, Yasuhiro Fujiwara, Akihito Nagahara, Osamu Kawamura, Ryuichi Iwakiri, Soji Ozawa, Kiyoshi Ashida, Shuichi Ohara, Hideyuki Kashiwagi, Kyoichi Adachi, Kazuhide Higuchi, Hiroto Miwa, Kazuma Fujimoto, Motoyasu Kusano, Yoshio Hoshihara, Tatsuyuki Kawano, Ken Haruma, Michio Hongo, Kentaro Sugano, Mamoru Watanabe, Tooru Shimosegawa

ABSTRACT

As an increase in gastroesophageal reflux disease (GERD) has been reported in Japan, and public interest in GERD has been increasing, the Japanese Society of Gastroenterology published the Evidence-based Clinical Practice Guidelines for GERD (1st edition) in 2009. Six years have passed since its publication, and there have been a large number of reports in Japan concerning the epidemiology, pathophysiology, treatment, and Barrett’s esophagus during this period. By incorporating the contents of these reports, the guidelines were completely revised, and a new edition was published in October 2015. The revised edition consists of eight items: epidemiology, pathophysiology, diagnosis, internal treatment, surgical treatment, esophagitis after surgery of the upper gastrointestinal tract, extraesophageal symptoms, and Barrett’s esophagus. This paper summarizes these guidelines, particularly the parts related to the treatment for GERD. In the present revision, aggressive proton pump inhibitor (PPI) maintenance therapy is recommended for severe erosive GERD, and on-demand therapy or continuous maintenance therapy is recommended for mild erosive GERD or PPI-responsive non-erosive GERD. Moreover, PPI-resistant GERD (insufficient symptomatic improvement and/or esophageal mucosal break persisting despite the administration of PPI at a standard dose for 8 weeks) is defined, and a standard-dose PPI twice a day, change in PPI, change in the PPI timing of dosing, addition of a prokinetic drug, addition of rikkunshito (traditional Japanese herbal medicine), and addition of histamine H2-receptor antagonist are recommended for its treatment. If no improvement is observed even after these treatments, pathophysiological evaluation with esophageal impedance-pH monitoring or esophageal manometry at an expert facility for diseases of the esophagus is recommended. More... »

PAGES

751-767

References to SciGraph publications

  • 2009-10-15. Chronic Proton Pump Inhibitor Therapy Associated with Increased Development of Fundic Gland Polyps in DIGESTIVE DISEASES AND SCIENCES
  • 2008-08. Association Between Use of Acid-Suppressive Drugs and Risk of Gastric Cancer in DRUG SAFETY
  • 2003-12-29. Does the learning phase influence the late outcome of patients with gastroesophageal reflux disease after laparoscopic fundoplication? in SURGICAL ENDOSCOPY
  • 2000-03. A prospective multicenter study on laparoscopic treatment of gastroesophageal reflux disease in Italy in SURGICAL ENDOSCOPY
  • 2011-12-15. Transoral incisionless fundoplication (TIF 2.0) with EsophyX for gastroesophageal reflux disease: long-term results and findings affecting outcome in SURGICAL ENDOSCOPY
  • 2009-05-12. H. pylori Eradication Prevents the Progression of Gastric Intestinal Metaplasia in Reflux Esophagitis Patients Using Long-Term Esomeprazole in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2004-09. Development and evaluation of FSSG: frequency scale for the symptoms of GERD in JOURNAL OF GASTROENTEROLOGY
  • 2008-11-18. Nationwide epidemiological study on gastroesophageal reflux disease and sleep disorders in the Japanese population in JOURNAL OF GASTROENTEROLOGY
  • 2009-05-14. Short-term and long-term outcome of endoluminal gastroplication for the treatment of GERD: the first multicenter trial in Japan in JOURNAL OF GASTROENTEROLOGY
  • 2005-11. “Proton-pump inhibitor-first” strategy versus “step-up” strategy for the acute treatment of reflux esophagitis: a cost-effectiveness analysis in Japan in JOURNAL OF GASTROENTEROLOGY
  • 2010-02-23. Incidence and risk factor of fundic gland polyp and hyperplastic polyp in long-term proton pump inhibitor therapy: a prospective study in Japan in JOURNAL OF GASTROENTEROLOGY
  • 2010-07-06. Risk factors for relapse of erosive GERD during long-term maintenance treatment with proton pump inhibitor: a prospective multicenter study in Japan in JOURNAL OF GASTROENTEROLOGY
  • 2009-03-31. The Impact of Lifestyle Modification on the Health-Related Quality of Life of Patients With Reflux Esophagitis Receiving Treatment With a Proton Pump Inhibitor in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2007-02-01. Open vs laparoscopic partial posterior fundoplication in SURGICAL ENDOSCOPY
  • 1998-02. Human Gastric Carcinoid Detected During Long-Term Antiulcer Therapy of H2 Receptor Antagonist and Proton Pump Inhibitor in DIGESTIVE DISEASES AND SCIENCES
  • 2007-11-03. Mechanisms of Acid Gastroesophageal Reflux in the Japanese Population in DIGESTIVE DISEASES AND SCIENCES
  • 2008-11-13. Mechanisms of Excessive Esophageal Acid Exposure in Patients with Reflux Esophagitis in DIGESTIVE DISEASES AND SCIENCES
  • 1983-06. Double-blind comparison of liquid antacid and placebo in the treatment of symptomatic reflux esophagitis in DIGESTIVE DISEASES AND SCIENCES
  • 2009-12-10. The prokinetic effect of mosapride citrate combined with omeprazole therapy improves clinical symptoms and gastric emptying in PPI-resistant NERD patients with delayed gastric emptying in JOURNAL OF GASTROENTEROLOGY
  • 2014-12-02. JSGE Clinical Practice Guidelines 2014: standards, methods, and process of developing the guidelines in JOURNAL OF GASTROENTEROLOGY
  • 2010-03-18. Postoperative recurrence factors of GERD in the elderly after laparoscopic fundoplication in ESOPHAGUS
  • 2002-11-01. Quality of life for patients with gastroesophageal reflux disease 2 years after laparoscopic fundoplication in SURGICAL ENDOSCOPY
  • 2011-04-12. Proton Pump Inhibitors and Risk of Fracture: A Systematic Review and Meta-Analysis of Observational Studies in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2002-10. Effect of cytochrome P4502C19 genotypic differences on cure rates for gastroesophageal reflux disease by lansoprazole in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2011-11-15. Rikkunshito improves symptoms in PPI-refractory GERD patients: a prospective, randomized, multicenter trial in Japan in JOURNAL OF GASTROENTEROLOGY
  • 2009-05-12. Acid and non-acid reflux in Japanese patients with non-erosive reflux disease with persistent reflux symptoms, despite taking a double-dose of proton pump inhibitor: a study using combined pH-impedance monitoring in JOURNAL OF GASTROENTEROLOGY
  • 2009-04-07. Proton pump inhibitors and risk of gastric cancer: a population-based cohort study in BRITISH JOURNAL OF CANCER
  • 2003-03-01. Epidemiology and pathophysiology of symptomatic gastroesophageal reflux disease in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2009-06-02. The Preoperative Reflux Pattern as Prognostic Indicator for Long-Term Outcome After Nissen Fundoplication in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2009-04-14. Epidemiology and clinical characteristics of GERD in the Japanese population in JOURNAL OF GASTROENTEROLOGY
  • 2003-03-01. Goals of therapy and guidelines for treatment success in symptomatic gastroesophageal reflux disease patients in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2008-05-01. Fundoplication for gastroesophageal reflux and factors associated with the outcome 6 to 10 years after the operation: multivariate analysis of prognostic factors using the propensity score in SURGICAL ENDOSCOPY
  • 1987-03. Double-blind controlled study on the efficacy of sodium alginate (Gaviscon) in reducing gastroesophageal reflux assessed by 24 h continuous pH monitoring in infants and children in EUROPEAN JOURNAL OF PEDIATRICS
  • 2005-01-01. Updated Guidelines for the Diagnosis and Treatment of Gastroesophageal Reflux Disease in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2011-11-16. Long-Term Follow-up of Barrett’s Epithelium: Medical Versus Antireflux Surgical Therapy in JOURNAL OF GASTROINTESTINAL SURGERY
  • 2012-03-20. Efficacy of Twice-Daily Rabeprazole for Reflux Esophagitis Patients Refractory to Standard Once-Daily Administration of PPI: The Japan-Based TWICE Study in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2012-02-23. Gaviscon® vs. omeprazole in symptomatic treatment of moderate gastroesophageal reflux. a direct comparative randomised trial in BMC GASTROENTEROLOGY
  • 2009-09-24. Initial Experience with New Intraluminal Devices for GERD Barrett’s Esophagus and Obesity in JOURNAL OF GASTROINTESTINAL SURGERY
  • 2007-05-17. Systematic Review of the Risk of Enteric Infection in Patients Taking Acid Suppression in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2007-12-05. Proton Pump Inhibitors and the Risk of Colorectal Cancer in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2011-04-13. Lifestyle Change Influences on GERD in Japan: A Study of Participants in a Health Examination Program in DIGESTIVE DISEASES AND SCIENCES
  • 2011-08-24. Investigation of pretreatment prediction of proton pump inhibitor (PPI)-resistant patients with gastroesophageal reflux disease and the dose escalation challenge of PPIs—TORNADO study: a multicenter prospective study by the Acid-Related Symptom Research Group in Japan in JOURNAL OF GASTROENTEROLOGY
  • 1999-06-01. Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 2006-08-01. The Montreal Definition and Classification of Gastroesophageal Reflux Disease: A Global Evidence-Based Consensus in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • 1992-04. Alginic acid decreases postprandial upright gastroesophageal reflux in DIGESTIVE DISEASES AND SCIENCES
  • 2010-09-30. Association of Long-Term Proton Pump Inhibitor Therapy with Bone Fractures and Effects on Absorption of Calcium, Vitamin B12, Iron, and Magnesium in CURRENT GASTROENTEROLOGY REPORTS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00535-016-1227-8

    DOI

    http://dx.doi.org/10.1007/s00535-016-1227-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1049466689

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27325300


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