Ontology type: schema:ScholarlyArticle Open Access: True
2015-03-31
AUTHORSAtsushi Hiraoka, Toshihiko Aibiki, Tomonari Okudaira, Akiko Toshimori, Tomoe Kawamura, Hiromasa Nakahara, Yoshifumi Suga, Nobuaki Azemoto, Hideki Miyata, Yasunao Miyamoto, Tomoyuki Ninomiya, Masashi Hirooka, Masanori Abe, Bunzo Matsuura, Yoichi Hiasa, Kojiro Michitaka
ABSTRACTBackground/AimThe definition of muscle atrophy (pre-sarcopenia) and its diagnostic criteria have not been well reported. To elucidate the frequency of pre-sarcopenia in chronic liver disease (CLD), we examined clinical features of Japanese CLD patients using abdominal computed tomography (CT) findings.MethodsWe enrolled 988 CLD (736 with naïve hepatocellular carcinoma) and 372 normal control subjects (NCs). The psoas muscle area index [PI, psoas muscle area at the mid-L3 level in CT (cm2)/height (m)2] was calculated using personal computer software. The cut-off level for pre-sarcopenia was defined as less than two standard deviations (SDs) below the mean PI value in the NCs under 55 years old [males, 45.6 ± 5.7 years (n = 61), 4.24 cm2/m2; females, 47.0 ± 6.1 years (n = 49), 2.50 cm2/m2]. Elderly was defined as 65 years or older. Clinical features were retrospectively evaluated.ResultsIn the CLD group (HCV:HBV:HBV and HCV:alcohol:non-HBV and HCV = 652:88:7:82:159), pre-sarcopenia was observed in 15.3 % of patients with chronic hepatitis (CH), 24.4 % of those with liver cirrhosis (LC) Child-Pugh A, 37.7 % of those with LC Child-Pugh B, and 37.1 % of those with LC Child-Pugh C. A comparison between NC and CH by age (<55, 55–64, 65–74, ≥75 years) showed that the frequency of pre-sarcopenia was higher in CH regardless of age (1.8 vs. 3.6 %, 3.2 vs. 15.9 %, 4.9 vs. 13.4 %, 14.3 vs. 20.2 %, respectively). PI values showed correlations with BMI (r = 0.361), age (r = −0.167), albumin (r = 0.115), and branched-chain amino acids (r = 0.199) (P < 0.01).ConclusionRetrospective evaluate for pre-sarcopenia was easy to perform with CT findings. Nutrition and exercise instruction should be considered for early stage and even non-elderly CLD as well as LC. More... »
PAGES1206-1213
http://scigraph.springernature.com/pub.10.1007/s00535-015-1068-x
DOIhttp://dx.doi.org/10.1007/s00535-015-1068-x
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/25820219
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"description": "Background/AimThe definition of muscle atrophy (pre-sarcopenia) and its diagnostic criteria have not been well reported. To elucidate the frequency of pre-sarcopenia in chronic liver disease (CLD), we examined clinical features of Japanese CLD patients using abdominal computed tomography (CT) findings.MethodsWe enrolled 988 CLD (736 with na\u00efve hepatocellular carcinoma) and 372 normal control subjects (NCs). The psoas muscle area index [PI, psoas muscle area at the mid-L3 level in CT (cm2)/height (m)2] was calculated using personal computer software. The cut-off level for pre-sarcopenia was defined as less than two standard deviations (SDs) below the mean PI value in the NCs under 55\u00a0years old [males, 45.6\u00a0\u00b1\u00a05.7\u00a0years (n\u00a0=\u00a061), 4.24\u00a0cm2/m2; females, 47.0\u00a0\u00b1\u00a06.1\u00a0years (n\u00a0=\u00a049), 2.50\u00a0cm2/m2]. Elderly was defined as 65\u00a0years or older. Clinical features were retrospectively evaluated.ResultsIn the CLD group (HCV:HBV:HBV and HCV:alcohol:non-HBV and HCV\u00a0=\u00a0652:88:7:82:159), pre-sarcopenia was observed in 15.3\u00a0% of patients with chronic hepatitis (CH), 24.4\u00a0% of those with liver cirrhosis (LC) Child-Pugh A, 37.7\u00a0% of those with LC Child-Pugh B, and 37.1\u00a0% of those with LC Child-Pugh C. A comparison between NC and CH by age (<55, 55\u201364, 65\u201374, \u226575\u00a0years) showed that the frequency of pre-sarcopenia was higher in CH regardless of age (1.8 vs. 3.6\u00a0%, 3.2 vs. 15.9\u00a0%, 4.9 vs. 13.4\u00a0%, 14.3 vs. 20.2\u00a0%, respectively). PI values showed correlations with BMI (r\u00a0=\u00a00.361), age (r\u00a0=\u00a0\u22120.167), albumin (r\u00a0=\u00a00.115), and branched-chain amino acids (r\u00a0=\u00a00.199) (P\u00a0<\u00a00.01).ConclusionRetrospective evaluate for pre-sarcopenia was easy to perform with CT findings. Nutrition and exercise instruction should be considered for early stage and even non-elderly CLD as well as LC.",
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