High-sensitivity Lens culinaris agglutinin-reactive alpha-fetoprotein assay predicts early detection of hepatocellular carcinoma View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-09-23

AUTHORS

Takashi Kumada, Hidenori Toyoda, Toshifumi Tada, Seiki Kiriyama, Makoto Tanikawa, Yasuhiro Hisanaga, Akira Kanamori, Junko Tanaka, Chiaki Kagebayashi, Shinji Satomura

ABSTRACT

BACKGROUND: Prognosis of patients with hepatocellular carcinoma (HCC) remains poor because HCC is frequently diagnosed late. Therefore, regular surveillance has been recommended to detect HCC at the early stage when curative treatments can be applied. HCC biomarkers, including Lens culinaris agglutinin-reactive fraction of alpha-fetoprotein (AFP-L3), are widely used for surveillance in Japan. A newly developed immunoassay system measures AFP-L3 % with high sensitivity. This retrospective study aimed to evaluate clinical utility of high-sensitivity AFP-L3 (hs-AFP-L3) as a predictor of early stage HCC in surveillance at a single site. METHODS: Of consecutive 2830 patients in the surveillance between 2000 and 2009, 104 HCC-developed and 104 non-HCC patients were selected by eligibility criteria and propensity score matching. Samples were obtained from the HCC patients who had blood drawn annually for 3 years prior to HCC diagnosis. RESULTS: In the present study, hs-AFP-L3 was elevated 1 year prior to diagnosis in 34.3 % of patients. The survival rate of patients with the hs-AFP-L3 ≥ 7 % at 1 year prior to diagnosis was significantly lower than that of patients with hs-AFP-L3 < 7 %. CONCLUSIONS: Elevation of hs-AFP-L3 was early predictive of development of HCC even at low AFP levels and in absence of ultrasound findings of suspicious HCC. The hs-AFP-L3 should be added to surveillance programs with US because elevated hs-AFP-L3 may be a trigger to perform enhanced imaging modalities for confirmation of HCC. More... »

PAGES

555-563

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00535-013-0883-1

DOI

http://dx.doi.org/10.1007/s00535-013-0883-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030245723

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24057163


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43 High-sensitivity Lens culinaris agglutinin-reactive alpha
44 Japan
45 L3
46 Lens culinaris agglutinin-reactive alpha
47 Lens culinaris agglutinin-reactive fraction
48 absence
49 agglutinin-reactive alpha
50 agglutinin-reactive fraction
51 alpha
52 alpha-fetoprotein
53 biomarkers
54 blood
55 carcinoma
56 clinical utility
57 confirmation
58 confirmation of HCC
59 criteria
60 culinaris agglutinin-reactive alpha
61 culinaris agglutinin-reactive fraction
62 curative treatment
63 detection
64 development
65 development of HCC
66 diagnosis
67 early detection
68 early stages
69 early-stage hepatocellular carcinoma
70 elevated hs-AFP
71 elevation
72 eligibility criteria
73 enhanced imaging modalities
74 fetoprotein
75 findings
76 fraction
77 hepatocellular carcinoma
78 high sensitivity
79 high-sensitivity AFP-L3
80 hs-AFP
81 imaging modalities
82 immunoassay system
83 levels
84 low AFP levels
85 modalities
86 non-HCC patients
87 patients
88 predictors
89 present study
90 prognosis
91 prognosis of patients
92 program
93 propensity score
94 rate
95 regular surveillance
96 retrospective study
97 samples
98 scores
99 sensitivity
100 single site
101 sites
102 stage
103 stage hepatocellular carcinoma
104 study
105 surveillance
106 survival rate
107 suspicious HCC
108 system
109 treatment
110 triggers
111 ultrasound findings
112 uses
113 utility
114 years
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