Novel risk factors for lymph node metastasis in early invasive colorectal cancer: a multi-institution pathology review View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-09-25

AUTHORS

Hideki Ueno, Kazuo Hase, Yojiro Hashiguchi, Hideyuki Shimazaki, Shinji Yoshii, Shin-ei Kudo, Masafumi Tanaka, Yoshito Akagi, Takeshi Suto, Shinji Nagata, Keiji Matsuda, Koji Komori, Kazuhiko Yoshimatsu, Yasuhiko Tomita, Shozo Yokoyama, Eiji Shinto, Takahiro Nakamura, Kenichi Sugihara

ABSTRACT

BackgroundNovel risk factors for lymph node metastasis (LNM) in T1 colorectal cancer (CRC) have been recently proposed, but most have not been implemented because of the lack of validation. Here we determined the value of poorly differentiated clusters (PDCs) in a multi-institutional cohort of T1 CRC cases.MethodsA pathology review involving 30 institutions was conducted for 3556 T1 CRCs. PDC was defined as malignant clusters comprising ≥5 cells and lacking a glandular formation. The ability to identify LNM risk was compared using Akaike’s information criterion (AIC).ResultsPDC was observed in 1401 tumors (39.4 %), including 94 (17.8 %) with <1000 µm submucosal invasion and 1307 (43.2 %) with ≥1000 µm submucosal invasion (P < 0.0001). The incidence of LNM was higher in PDC-positive tumors (17.4 %) than in PDC-negative tumors (6.9 %; P < 0.0001), and PDCs had an adverse impact on LNM irrespective of the degree of submucosal invasion. Grade 3, vascular invasion, budding, and submucosal invasion depth were also significant factors (all, P < 0.0001). AIC of risk factor to identify LNM risk was most favorable for vascular invasion (2273.4), followed by PDC (2357.4); submucosal invasion depth (2429.1) was the most unfavorable. Interinstitutional judgment disparities were smaller in PDC (kappa, 0.51) than vascular invasion (0.33) or tumor grade (0.48).ConclusionsPDC is a promising new parameter with good ability to identify LNM risk. Use of its appropriate judgment criteria will enable us determine whether an observational policy can be safely applied following local tumor excision in T1 CRC cases. More... »

PAGES

1314-1323

References to SciGraph publications

  • 2012-04-24. Tumour budding: a promising parameter in colorectal cancer in BRITISH JOURNAL OF CANCER
  • 2006-01-10. Tumour budding at the deepest invasive margin correlates with lymph node metastasis in submucosal colorectal cancer detected by anticytokeratin antibody CAM5.2 in BRITISH JOURNAL OF CANCER
  • 2004-03-05. Analysis of pathological risk factors for lymph node metastasis of submucosal invasive colon cancer in MODERN PATHOLOGY
  • 2004-06. Correlations between lymph node metastasis and depth of submucosal invasion in submucosal invasive colorectal carcinoma: a Japanese collaborative study in JOURNAL OF GASTROENTEROLOGY
  • 2008-09-27. Pathological predictors for lymph node metastasis in T1 colorectal cancer in SURGERY TODAY
  • 2012-06-23. Endoscopic submucosal dissection for colorectal tumors—1,000 colorectal ESD cases: one specialized institute’s experiences in SURGICAL ENDOSCOPY
  • 2012-10-24. Colorectal carcinoma grading by quantifying poorly differentiated cell clusters is more reproducible and provides more robust prognostic information than conventional grading in VIRCHOWS ARCHIV
  • 2011-10-15. Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2010 for the treatment of colorectal cancer in INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
  • 2009-11-06. The concurrence of histologically positive resection margins and sessile morphology is an important risk factor for lymph node metastasis after complete endoscopic removal of malignant colorectal polyps in INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
  • 2012-03-29. Additional colectomy after colonoscopic polypectomy for T1 colon cancer: a fine balance between oncologic benefit and operative risk in INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
  • 2010-05-14. Pathological prognostic factors predicting lymph node metastasis in submucosal invasive (T1) colorectal carcinoma in MODERN PATHOLOGY
  • Journal

    TITLE

    Journal of Gastroenterology

    ISSUE

    9

    VOLUME

    49

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00535-013-0881-3

    DOI

    http://dx.doi.org/10.1007/s00535-013-0881-3

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1018142607

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24065123


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Colorectal Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Incidence", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphatic Metastasis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Male", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Grading", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Neoplasm Invasiveness", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Risk Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Young Adult", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Surgery, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.416614.0", 
              "name": [
                "Department of Surgery, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Ueno", 
            "givenName": "Hideki", 
            "id": "sg:person.01053200431.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053200431.41"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.416614.0", 
              "name": [
                "Department of Surgery, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hase", 
            "givenName": "Kazuo", 
            "id": "sg:person.01251324614.42", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251324614.42"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.264706.1", 
              "name": [
                "Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hashiguchi", 
            "givenName": "Yojiro", 
            "id": "sg:person.0667170237.99", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667170237.99"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Laboratory Medicine, National Defense Medical College, Tokorozawa, Japan", 
              "id": "http://www.grid.ac/institutes/grid.416614.0", 
              "name": [
                "Department of Laboratory Medicine, National Defense Medical College, Tokorozawa, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shimazaki", 
            "givenName": "Hideyuki", 
            "id": "sg:person.01124052601.44", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124052601.44"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterology, Keiyukai Sappro Hospital, Sapporo, Japan", 
              "id": "http://www.grid.ac/institutes/None", 
              "name": [
                "Department of Gastroenterology, Keiyukai Sappro Hospital, Sapporo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yoshii", 
            "givenName": "Shinji", 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Digestive Disease Center, Showa University, Northern Yokohama Hospital, Yokohama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.482675.a", 
              "name": [
                "Digestive Disease Center, Showa University, Northern Yokohama Hospital, Yokohama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kudo", 
            "givenName": "Shin-ei", 
            "id": "sg:person.01165740710.48", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165740710.48"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, Coloproctology Center, Takano Hospital, Kumamoto, Japan", 
              "id": "http://www.grid.ac/institutes/grid.416855.b", 
              "name": [
                "Department of Surgery, Coloproctology Center, Takano Hospital, Kumamoto, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tanaka", 
            "givenName": "Masafumi", 
            "id": "sg:person.01370067464.16", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370067464.16"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, Kurume University Faculty of Medicine, Kurume, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410781.b", 
              "name": [
                "Department of Surgery, Kurume University Faculty of Medicine, Kurume, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Akagi", 
            "givenName": "Yoshito", 
            "id": "sg:person.01065344401.26", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065344401.26"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, Yamagata Prefectural Central Hospital, Yamagata, Japan", 
              "id": "http://www.grid.ac/institutes/grid.417323.0", 
              "name": [
                "Department of Surgery, Yamagata Prefectural Central Hospital, Yamagata, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Suto", 
            "givenName": "Takeshi", 
            "id": "sg:person.01073077743.21", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073077743.21"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Endoscopy, Hiroshima City Asa Hospital, Hiroshima, Japan", 
              "id": "http://www.grid.ac/institutes/grid.414157.2", 
              "name": [
                "Department of Endoscopy, Hiroshima City Asa Hospital, Hiroshima, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nagata", 
            "givenName": "Shinji", 
            "id": "sg:person.01344211765.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344211765.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.264706.1", 
              "name": [
                "Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Matsuda", 
            "givenName": "Keiji", 
            "id": "sg:person.01223516634.34", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223516634.34"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan", 
              "id": "http://www.grid.ac/institutes/grid.410800.d", 
              "name": [
                "Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Komori", 
            "givenName": "Koji", 
            "id": "sg:person.01344637260.96", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344637260.96"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, Tokyo Women\u2019s Medical University Medical Center East, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.413376.4", 
              "name": [
                "Department of Surgery, Tokyo Women\u2019s Medical University Medical Center East, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yoshimatsu", 
            "givenName": "Kazuhiko", 
            "id": "sg:person.0706255133.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706255133.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan", 
              "id": "http://www.grid.ac/institutes/grid.416963.f", 
              "name": [
                "Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Tomita", 
            "givenName": "Yasuhiko", 
            "id": "sg:person.01154516333.63", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154516333.63"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.412857.d", 
              "name": [
                "Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Yokoyama", 
            "givenName": "Shozo", 
            "id": "sg:person.01021110733.45", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021110733.45"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgery, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan", 
              "id": "http://www.grid.ac/institutes/grid.416614.0", 
              "name": [
                "Department of Surgery, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Shinto", 
            "givenName": "Eiji", 
            "id": "sg:person.0621055037.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621055037.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Laboratory for Mathematics, National Defense Medical College, Tokorozawa, Japan", 
              "id": "http://www.grid.ac/institutes/grid.416614.0", 
              "name": [
                "Laboratory for Mathematics, National Defense Medical College, Tokorozawa, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Nakamura", 
            "givenName": "Takahiro", 
            "id": "sg:person.0744655131.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744655131.04"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Surgical Oncology, Tokyo Medical and Dental University, Tokyo, Japan", 
              "id": "http://www.grid.ac/institutes/grid.265073.5", 
              "name": [
                "Department of Surgical Oncology, Tokyo Medical and Dental University, Tokyo, Japan"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Sugihara", 
            "givenName": "Kenichi", 
            "id": "sg:person.01335627070.04", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335627070.04"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/modpathol.3800030", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000380328", 
              "https://doi.org/10.1038/modpathol.3800030"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00384-012-1464-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008058781", 
              "https://doi.org/10.1007/s00384-012-1464-0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00428-012-1326-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1037988347", 
              "https://doi.org/10.1007/s00428-012-1326-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00464-012-2403-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009558282", 
              "https://doi.org/10.1007/s00464-012-2403-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00384-009-0836-6", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003415482", 
              "https://doi.org/10.1007/s00384-009-0836-6"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/modpathol.2010.88", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002108517", 
              "https://doi.org/10.1038/modpathol.2010.88"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6602927", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007154455", 
              "https://doi.org/10.1038/sj.bjc.6602927"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00595-007-3751-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050689492", 
              "https://doi.org/10.1007/s00595-007-3751-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00535-004-1339-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020821843", 
              "https://doi.org/10.1007/s00535-004-1339-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2012.127", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028388342", 
              "https://doi.org/10.1038/bjc.2012.127"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10147-011-0315-2", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1052442439", 
              "https://doi.org/10.1007/s10147-011-0315-2"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2013-09-25", 
        "datePublishedReg": "2013-09-25", 
        "description": "BackgroundNovel risk factors for lymph node metastasis (LNM) in T1 colorectal cancer (CRC) have been recently proposed, but most have not been implemented because of the lack of validation. Here we determined the value of poorly differentiated clusters (PDCs) in a multi-institutional cohort of T1 CRC cases.MethodsA pathology review involving 30 institutions was conducted for 3556 T1 CRCs. PDC was defined as malignant clusters comprising \u22655 cells and lacking a glandular formation. The ability to identify LNM risk was compared using Akaike\u2019s information criterion (AIC).ResultsPDC was observed in 1401 tumors (39.4\u00a0%), including 94 (17.8\u00a0%) with <1000\u00a0\u00b5m submucosal invasion and 1307 (43.2\u00a0%) with \u22651000\u00a0\u00b5m submucosal invasion (P\u00a0<\u00a00.0001). The incidence of LNM was higher in PDC-positive tumors (17.4\u00a0%) than in PDC-negative tumors (6.9\u00a0%; P\u00a0<\u00a00.0001), and PDCs had an adverse impact on LNM irrespective of the degree of submucosal invasion. Grade 3, vascular invasion, budding, and submucosal invasion depth were also significant factors (all, P\u00a0<\u00a00.0001). AIC of risk factor to identify LNM risk was most favorable for vascular invasion (2273.4), followed by PDC (2357.4); submucosal invasion depth (2429.1) was the most unfavorable. Interinstitutional judgment disparities were smaller in PDC (kappa, 0.51) than vascular invasion (0.33) or tumor grade (0.48).ConclusionsPDC is a promising new parameter with good ability to identify LNM risk. Use of its appropriate judgment criteria will enable us determine whether an observational policy can be safely applied following local tumor excision in T1 CRC cases.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s00535-013-0881-3", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.6124085", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1009747", 
            "issn": [
              "0944-1174", 
              "1435-5922"
            ], 
            "name": "Journal of Gastroenterology", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "9", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "49"
          }
        ], 
        "keywords": [
          "lymph node metastasis", 
          "submucosal invasion depth", 
          "colorectal cancer", 
          "LNM risk", 
          "submucosal invasion", 
          "vascular invasion", 
          "risk factors", 
          "node metastasis", 
          "pathology review", 
          "CRC cases", 
          "incidence of LNM", 
          "invasion depth", 
          "early invasive colorectal cancer", 
          "T1 colorectal cancer", 
          "local tumor excision", 
          "invasive colorectal cancer", 
          "multi-institutional cohort", 
          "novel risk factors", 
          "tumor excision", 
          "tumor grade", 
          "grade 3", 
          "observational policy", 
          "glandular formation", 
          "promising new parameter", 
          "tumors", 
          "lack of validation", 
          "metastasis", 
          "invasion", 
          "cancer", 
          "risk", 
          "PDC", 
          "significant factor", 
          "review", 
          "factors", 
          "cohort", 
          "excision", 
          "incidence", 
          "malignant clusters", 
          "Akaike information criterion", 
          "criteria", 
          "cases", 
          "cells", 
          "grade", 
          "adverse impact", 
          "disparities", 
          "ability", 
          "judgment criteria", 
          "lack", 
          "information criterion", 
          "good ability", 
          "use", 
          "budding", 
          "institutions", 
          "impact", 
          "degree", 
          "validation", 
          "new parameter", 
          "values", 
          "clusters", 
          "formation", 
          "parameters", 
          "depth", 
          "policy", 
          "BackgroundNovel risk factors", 
          "T1 CRC cases", 
          "MethodsA pathology review", 
          "ResultsPDC", 
          "PDC-positive tumors", 
          "PDC-negative tumors", 
          "Interinstitutional judgment disparities", 
          "judgment disparities", 
          "ConclusionsPDC", 
          "appropriate judgment criteria", 
          "multi-institution pathology review"
        ], 
        "name": "Novel risk factors for lymph node metastasis in early invasive colorectal cancer: a multi-institution pathology review", 
        "pagination": "1314-1323", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1018142607"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s00535-013-0881-3"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "24065123"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s00535-013-0881-3", 
          "https://app.dimensions.ai/details/publication/pub.1018142607"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2022-01-01T18:30", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20220101/entities/gbq_results/article/article_607.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s00535-013-0881-3"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00535-013-0881-3'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00535-013-0881-3'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00535-013-0881-3'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00535-013-0881-3'


     

    This table displays all metadata directly associated to this object as RDF triples.

    396 TRIPLES      22 PREDICATES      125 URIs      106 LITERALS      21 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s00535-013-0881-3 schema:about N1ac94560af5844718da787cc9b61c916
    2 N2c74478752e547eeb0ada34c5c7ec681
    3 N30b1b741cdbd4bb69801ecb0a862e4b2
    4 N3f43204ed8e34baab0a8e68427a663b6
    5 N75b6ed5627354b75ba0a44bf7827eb67
    6 N7759990c9b124faba0c44d8f63e450a7
    7 N79dc47a833174cddb4b0d8cd947000df
    8 N850e0dfecc324fabb73d26b7422788fa
    9 Nb7bbb411dac84c3db533d5547bd60d3f
    10 Nda871e26c3854357b64e6f3ad145793b
    11 Ndab90caca4c64949af176585f1ffe433
    12 Ndd38e29795c642488d3951d8668cd10d
    13 Ne9b3221d4bd947149f452bb5bebb1170
    14 Nf1d2fff2ec2146f581856a659b84ee9b
    15 anzsrc-for:11
    16 anzsrc-for:1112
    17 schema:author N94ba5a9da0314631bfd67a0d93689fd4
    18 schema:citation sg:pub.10.1007/s00384-009-0836-6
    19 sg:pub.10.1007/s00384-012-1464-0
    20 sg:pub.10.1007/s00428-012-1326-8
    21 sg:pub.10.1007/s00464-012-2403-4
    22 sg:pub.10.1007/s00535-004-1339-4
    23 sg:pub.10.1007/s00595-007-3751-x
    24 sg:pub.10.1007/s10147-011-0315-2
    25 sg:pub.10.1038/bjc.2012.127
    26 sg:pub.10.1038/modpathol.2010.88
    27 sg:pub.10.1038/modpathol.3800030
    28 sg:pub.10.1038/sj.bjc.6602927
    29 schema:datePublished 2013-09-25
    30 schema:datePublishedReg 2013-09-25
    31 schema:description BackgroundNovel risk factors for lymph node metastasis (LNM) in T1 colorectal cancer (CRC) have been recently proposed, but most have not been implemented because of the lack of validation. Here we determined the value of poorly differentiated clusters (PDCs) in a multi-institutional cohort of T1 CRC cases.MethodsA pathology review involving 30 institutions was conducted for 3556 T1 CRCs. PDC was defined as malignant clusters comprising ≥5 cells and lacking a glandular formation. The ability to identify LNM risk was compared using Akaike’s information criterion (AIC).ResultsPDC was observed in 1401 tumors (39.4 %), including 94 (17.8 %) with <1000 µm submucosal invasion and 1307 (43.2 %) with ≥1000 µm submucosal invasion (P < 0.0001). The incidence of LNM was higher in PDC-positive tumors (17.4 %) than in PDC-negative tumors (6.9 %; P < 0.0001), and PDCs had an adverse impact on LNM irrespective of the degree of submucosal invasion. Grade 3, vascular invasion, budding, and submucosal invasion depth were also significant factors (all, P < 0.0001). AIC of risk factor to identify LNM risk was most favorable for vascular invasion (2273.4), followed by PDC (2357.4); submucosal invasion depth (2429.1) was the most unfavorable. Interinstitutional judgment disparities were smaller in PDC (kappa, 0.51) than vascular invasion (0.33) or tumor grade (0.48).ConclusionsPDC is a promising new parameter with good ability to identify LNM risk. Use of its appropriate judgment criteria will enable us determine whether an observational policy can be safely applied following local tumor excision in T1 CRC cases.
    32 schema:genre article
    33 schema:inLanguage en
    34 schema:isAccessibleForFree false
    35 schema:isPartOf Nae2607bed4f946029755ee0cc26e3037
    36 Nfa750cb59d7a481d9f82a04ef8db4f64
    37 sg:journal.1009747
    38 schema:keywords Akaike information criterion
    39 BackgroundNovel risk factors
    40 CRC cases
    41 ConclusionsPDC
    42 Interinstitutional judgment disparities
    43 LNM risk
    44 MethodsA pathology review
    45 PDC
    46 PDC-negative tumors
    47 PDC-positive tumors
    48 ResultsPDC
    49 T1 CRC cases
    50 T1 colorectal cancer
    51 ability
    52 adverse impact
    53 appropriate judgment criteria
    54 budding
    55 cancer
    56 cases
    57 cells
    58 clusters
    59 cohort
    60 colorectal cancer
    61 criteria
    62 degree
    63 depth
    64 disparities
    65 early invasive colorectal cancer
    66 excision
    67 factors
    68 formation
    69 glandular formation
    70 good ability
    71 grade
    72 grade 3
    73 impact
    74 incidence
    75 incidence of LNM
    76 information criterion
    77 institutions
    78 invasion
    79 invasion depth
    80 invasive colorectal cancer
    81 judgment criteria
    82 judgment disparities
    83 lack
    84 lack of validation
    85 local tumor excision
    86 lymph node metastasis
    87 malignant clusters
    88 metastasis
    89 multi-institution pathology review
    90 multi-institutional cohort
    91 new parameter
    92 node metastasis
    93 novel risk factors
    94 observational policy
    95 parameters
    96 pathology review
    97 policy
    98 promising new parameter
    99 review
    100 risk
    101 risk factors
    102 significant factor
    103 submucosal invasion
    104 submucosal invasion depth
    105 tumor excision
    106 tumor grade
    107 tumors
    108 use
    109 validation
    110 values
    111 vascular invasion
    112 schema:name Novel risk factors for lymph node metastasis in early invasive colorectal cancer: a multi-institution pathology review
    113 schema:pagination 1314-1323
    114 schema:productId N375e048144244d27a99bba07c8013ee2
    115 N9532e759ecb14152aaa02c1192d54f15
    116 N9ce5e43b2db045cca7cae1580be3b567
    117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018142607
    118 https://doi.org/10.1007/s00535-013-0881-3
    119 schema:sdDatePublished 2022-01-01T18:30
    120 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    121 schema:sdPublisher N9fecaca48eae42a084c25c0257667932
    122 schema:url https://doi.org/10.1007/s00535-013-0881-3
    123 sgo:license sg:explorer/license/
    124 sgo:sdDataset articles
    125 rdf:type schema:ScholarlyArticle
    126 N0011c0d8e2354055bda99c13928a6c94 rdf:first sg:person.01065344401.26
    127 rdf:rest Nda46ad3c15764254a7ee0514a8583c9d
    128 N1ac94560af5844718da787cc9b61c916 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Adult
    130 rdf:type schema:DefinedTerm
    131 N214d00e5084d463381794f70e26fb72f rdf:first sg:person.01370067464.16
    132 rdf:rest N0011c0d8e2354055bda99c13928a6c94
    133 N23484d636e41445096e34854c8eb9a9d rdf:first sg:person.01344637260.96
    134 rdf:rest N580cf6eae2644271b846487e83811db1
    135 N26e7f88a86154077a354588a74c9dafd rdf:first sg:person.01223516634.34
    136 rdf:rest N23484d636e41445096e34854c8eb9a9d
    137 N2c6df3d7e4de47d08a4fab7f45b639ca rdf:first sg:person.0667170237.99
    138 rdf:rest N474b369aba524e258d5de1aa41c2e235
    139 N2c74478752e547eeb0ada34c5c7ec681 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    140 schema:name Male
    141 rdf:type schema:DefinedTerm
    142 N30b1b741cdbd4bb69801ecb0a862e4b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    143 schema:name Colorectal Neoplasms
    144 rdf:type schema:DefinedTerm
    145 N370e4c3ac6444b1b874be9f9ca4bf658 rdf:first N3f279ce8e4b44dfa8300d47c892e4774
    146 rdf:rest Nb7c2bb333ac440f2b1f53ab9f685e3e3
    147 N375e048144244d27a99bba07c8013ee2 schema:name doi
    148 schema:value 10.1007/s00535-013-0881-3
    149 rdf:type schema:PropertyValue
    150 N39e65506eed6460abbc7d3f4c6883ba4 rdf:first sg:person.0621055037.04
    151 rdf:rest N6e8980b0bf0840bca60e9a9606b5200c
    152 N3f279ce8e4b44dfa8300d47c892e4774 schema:affiliation grid-institutes:None
    153 schema:familyName Yoshii
    154 schema:givenName Shinji
    155 rdf:type schema:Person
    156 N3f43204ed8e34baab0a8e68427a663b6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    157 schema:name Aged
    158 rdf:type schema:DefinedTerm
    159 N474b369aba524e258d5de1aa41c2e235 rdf:first sg:person.01124052601.44
    160 rdf:rest N370e4c3ac6444b1b874be9f9ca4bf658
    161 N580cf6eae2644271b846487e83811db1 rdf:first sg:person.0706255133.04
    162 rdf:rest N99252e880ab04112b8c7f0583add30fb
    163 N67ebafeeb65a41bca3f2d20ebfab0f4e rdf:first sg:person.01344211765.50
    164 rdf:rest N26e7f88a86154077a354588a74c9dafd
    165 N694c428916be438bbdf6668bce66380b rdf:first sg:person.01251324614.42
    166 rdf:rest N2c6df3d7e4de47d08a4fab7f45b639ca
    167 N6e8980b0bf0840bca60e9a9606b5200c rdf:first sg:person.0744655131.04
    168 rdf:rest N80b2d816486a422f928b2ba6b7ffeb57
    169 N75b6ed5627354b75ba0a44bf7827eb67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    170 schema:name Humans
    171 rdf:type schema:DefinedTerm
    172 N7759990c9b124faba0c44d8f63e450a7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    173 schema:name Young Adult
    174 rdf:type schema:DefinedTerm
    175 N79dc47a833174cddb4b0d8cd947000df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    176 schema:name Risk Factors
    177 rdf:type schema:DefinedTerm
    178 N80b2d816486a422f928b2ba6b7ffeb57 rdf:first sg:person.01335627070.04
    179 rdf:rest rdf:nil
    180 N850e0dfecc324fabb73d26b7422788fa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    181 schema:name Middle Aged
    182 rdf:type schema:DefinedTerm
    183 N94ba5a9da0314631bfd67a0d93689fd4 rdf:first sg:person.01053200431.41
    184 rdf:rest N694c428916be438bbdf6668bce66380b
    185 N9532e759ecb14152aaa02c1192d54f15 schema:name pubmed_id
    186 schema:value 24065123
    187 rdf:type schema:PropertyValue
    188 N99252e880ab04112b8c7f0583add30fb rdf:first sg:person.01154516333.63
    189 rdf:rest Nb071591d71a044a6b907c76376899558
    190 N9ce5e43b2db045cca7cae1580be3b567 schema:name dimensions_id
    191 schema:value pub.1018142607
    192 rdf:type schema:PropertyValue
    193 N9fecaca48eae42a084c25c0257667932 schema:name Springer Nature - SN SciGraph project
    194 rdf:type schema:Organization
    195 Nae2607bed4f946029755ee0cc26e3037 schema:issueNumber 9
    196 rdf:type schema:PublicationIssue
    197 Nb071591d71a044a6b907c76376899558 rdf:first sg:person.01021110733.45
    198 rdf:rest N39e65506eed6460abbc7d3f4c6883ba4
    199 Nb7bbb411dac84c3db533d5547bd60d3f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    200 schema:name Incidence
    201 rdf:type schema:DefinedTerm
    202 Nb7c2bb333ac440f2b1f53ab9f685e3e3 rdf:first sg:person.01165740710.48
    203 rdf:rest N214d00e5084d463381794f70e26fb72f
    204 Nda46ad3c15764254a7ee0514a8583c9d rdf:first sg:person.01073077743.21
    205 rdf:rest N67ebafeeb65a41bca3f2d20ebfab0f4e
    206 Nda871e26c3854357b64e6f3ad145793b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    207 schema:name Aged, 80 and over
    208 rdf:type schema:DefinedTerm
    209 Ndab90caca4c64949af176585f1ffe433 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    210 schema:name Female
    211 rdf:type schema:DefinedTerm
    212 Ndd38e29795c642488d3951d8668cd10d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    213 schema:name Lymphatic Metastasis
    214 rdf:type schema:DefinedTerm
    215 Ne9b3221d4bd947149f452bb5bebb1170 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    216 schema:name Neoplasm Invasiveness
    217 rdf:type schema:DefinedTerm
    218 Nf1d2fff2ec2146f581856a659b84ee9b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    219 schema:name Neoplasm Grading
    220 rdf:type schema:DefinedTerm
    221 Nfa750cb59d7a481d9f82a04ef8db4f64 schema:volumeNumber 49
    222 rdf:type schema:PublicationVolume
    223 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    224 schema:name Medical and Health Sciences
    225 rdf:type schema:DefinedTerm
    226 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    227 schema:name Oncology and Carcinogenesis
    228 rdf:type schema:DefinedTerm
    229 sg:grant.6124085 http://pending.schema.org/fundedItem sg:pub.10.1007/s00535-013-0881-3
    230 rdf:type schema:MonetaryGrant
    231 sg:journal.1009747 schema:issn 0944-1174
    232 1435-5922
    233 schema:name Journal of Gastroenterology
    234 schema:publisher Springer Nature
    235 rdf:type schema:Periodical
    236 sg:person.01021110733.45 schema:affiliation grid-institutes:grid.412857.d
    237 schema:familyName Yokoyama
    238 schema:givenName Shozo
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01021110733.45
    240 rdf:type schema:Person
    241 sg:person.01053200431.41 schema:affiliation grid-institutes:grid.416614.0
    242 schema:familyName Ueno
    243 schema:givenName Hideki
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053200431.41
    245 rdf:type schema:Person
    246 sg:person.01065344401.26 schema:affiliation grid-institutes:grid.410781.b
    247 schema:familyName Akagi
    248 schema:givenName Yoshito
    249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065344401.26
    250 rdf:type schema:Person
    251 sg:person.01073077743.21 schema:affiliation grid-institutes:grid.417323.0
    252 schema:familyName Suto
    253 schema:givenName Takeshi
    254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01073077743.21
    255 rdf:type schema:Person
    256 sg:person.01124052601.44 schema:affiliation grid-institutes:grid.416614.0
    257 schema:familyName Shimazaki
    258 schema:givenName Hideyuki
    259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01124052601.44
    260 rdf:type schema:Person
    261 sg:person.01154516333.63 schema:affiliation grid-institutes:grid.416963.f
    262 schema:familyName Tomita
    263 schema:givenName Yasuhiko
    264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01154516333.63
    265 rdf:type schema:Person
    266 sg:person.01165740710.48 schema:affiliation grid-institutes:grid.482675.a
    267 schema:familyName Kudo
    268 schema:givenName Shin-ei
    269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01165740710.48
    270 rdf:type schema:Person
    271 sg:person.01223516634.34 schema:affiliation grid-institutes:grid.264706.1
    272 schema:familyName Matsuda
    273 schema:givenName Keiji
    274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01223516634.34
    275 rdf:type schema:Person
    276 sg:person.01251324614.42 schema:affiliation grid-institutes:grid.416614.0
    277 schema:familyName Hase
    278 schema:givenName Kazuo
    279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251324614.42
    280 rdf:type schema:Person
    281 sg:person.01335627070.04 schema:affiliation grid-institutes:grid.265073.5
    282 schema:familyName Sugihara
    283 schema:givenName Kenichi
    284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335627070.04
    285 rdf:type schema:Person
    286 sg:person.01344211765.50 schema:affiliation grid-institutes:grid.414157.2
    287 schema:familyName Nagata
    288 schema:givenName Shinji
    289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344211765.50
    290 rdf:type schema:Person
    291 sg:person.01344637260.96 schema:affiliation grid-institutes:grid.410800.d
    292 schema:familyName Komori
    293 schema:givenName Koji
    294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01344637260.96
    295 rdf:type schema:Person
    296 sg:person.01370067464.16 schema:affiliation grid-institutes:grid.416855.b
    297 schema:familyName Tanaka
    298 schema:givenName Masafumi
    299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370067464.16
    300 rdf:type schema:Person
    301 sg:person.0621055037.04 schema:affiliation grid-institutes:grid.416614.0
    302 schema:familyName Shinto
    303 schema:givenName Eiji
    304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0621055037.04
    305 rdf:type schema:Person
    306 sg:person.0667170237.99 schema:affiliation grid-institutes:grid.264706.1
    307 schema:familyName Hashiguchi
    308 schema:givenName Yojiro
    309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0667170237.99
    310 rdf:type schema:Person
    311 sg:person.0706255133.04 schema:affiliation grid-institutes:grid.413376.4
    312 schema:familyName Yoshimatsu
    313 schema:givenName Kazuhiko
    314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0706255133.04
    315 rdf:type schema:Person
    316 sg:person.0744655131.04 schema:affiliation grid-institutes:grid.416614.0
    317 schema:familyName Nakamura
    318 schema:givenName Takahiro
    319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744655131.04
    320 rdf:type schema:Person
    321 sg:pub.10.1007/s00384-009-0836-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003415482
    322 https://doi.org/10.1007/s00384-009-0836-6
    323 rdf:type schema:CreativeWork
    324 sg:pub.10.1007/s00384-012-1464-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008058781
    325 https://doi.org/10.1007/s00384-012-1464-0
    326 rdf:type schema:CreativeWork
    327 sg:pub.10.1007/s00428-012-1326-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037988347
    328 https://doi.org/10.1007/s00428-012-1326-8
    329 rdf:type schema:CreativeWork
    330 sg:pub.10.1007/s00464-012-2403-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009558282
    331 https://doi.org/10.1007/s00464-012-2403-4
    332 rdf:type schema:CreativeWork
    333 sg:pub.10.1007/s00535-004-1339-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020821843
    334 https://doi.org/10.1007/s00535-004-1339-4
    335 rdf:type schema:CreativeWork
    336 sg:pub.10.1007/s00595-007-3751-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050689492
    337 https://doi.org/10.1007/s00595-007-3751-x
    338 rdf:type schema:CreativeWork
    339 sg:pub.10.1007/s10147-011-0315-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052442439
    340 https://doi.org/10.1007/s10147-011-0315-2
    341 rdf:type schema:CreativeWork
    342 sg:pub.10.1038/bjc.2012.127 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028388342
    343 https://doi.org/10.1038/bjc.2012.127
    344 rdf:type schema:CreativeWork
    345 sg:pub.10.1038/modpathol.2010.88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002108517
    346 https://doi.org/10.1038/modpathol.2010.88
    347 rdf:type schema:CreativeWork
    348 sg:pub.10.1038/modpathol.3800030 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000380328
    349 https://doi.org/10.1038/modpathol.3800030
    350 rdf:type schema:CreativeWork
    351 sg:pub.10.1038/sj.bjc.6602927 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007154455
    352 https://doi.org/10.1038/sj.bjc.6602927
    353 rdf:type schema:CreativeWork
    354 grid-institutes:None schema:alternateName Department of Gastroenterology, Keiyukai Sappro Hospital, Sapporo, Japan
    355 schema:name Department of Gastroenterology, Keiyukai Sappro Hospital, Sapporo, Japan
    356 rdf:type schema:Organization
    357 grid-institutes:grid.264706.1 schema:alternateName Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    358 schema:name Department of Surgery, Teikyo University School of Medicine, Tokyo, Japan
    359 rdf:type schema:Organization
    360 grid-institutes:grid.265073.5 schema:alternateName Department of Surgical Oncology, Tokyo Medical and Dental University, Tokyo, Japan
    361 schema:name Department of Surgical Oncology, Tokyo Medical and Dental University, Tokyo, Japan
    362 rdf:type schema:Organization
    363 grid-institutes:grid.410781.b schema:alternateName Department of Surgery, Kurume University Faculty of Medicine, Kurume, Japan
    364 schema:name Department of Surgery, Kurume University Faculty of Medicine, Kurume, Japan
    365 rdf:type schema:Organization
    366 grid-institutes:grid.410800.d schema:alternateName Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
    367 schema:name Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
    368 rdf:type schema:Organization
    369 grid-institutes:grid.412857.d schema:alternateName Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan
    370 schema:name Second Department of Surgery, Wakayama Medical University, School of Medicine, Wakayama, Japan
    371 rdf:type schema:Organization
    372 grid-institutes:grid.413376.4 schema:alternateName Department of Surgery, Tokyo Women’s Medical University Medical Center East, Tokyo, Japan
    373 schema:name Department of Surgery, Tokyo Women’s Medical University Medical Center East, Tokyo, Japan
    374 rdf:type schema:Organization
    375 grid-institutes:grid.414157.2 schema:alternateName Department of Endoscopy, Hiroshima City Asa Hospital, Hiroshima, Japan
    376 schema:name Department of Endoscopy, Hiroshima City Asa Hospital, Hiroshima, Japan
    377 rdf:type schema:Organization
    378 grid-institutes:grid.416614.0 schema:alternateName Department of Laboratory Medicine, National Defense Medical College, Tokorozawa, Japan
    379 Department of Surgery, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan
    380 Laboratory for Mathematics, National Defense Medical College, Tokorozawa, Japan
    381 schema:name Department of Laboratory Medicine, National Defense Medical College, Tokorozawa, Japan
    382 Department of Surgery, National Defense Medical College, 3-2 Namiki, 359-8513, Tokorozawa, Saitama, Japan
    383 Laboratory for Mathematics, National Defense Medical College, Tokorozawa, Japan
    384 rdf:type schema:Organization
    385 grid-institutes:grid.416855.b schema:alternateName Department of Surgery, Coloproctology Center, Takano Hospital, Kumamoto, Japan
    386 schema:name Department of Surgery, Coloproctology Center, Takano Hospital, Kumamoto, Japan
    387 rdf:type schema:Organization
    388 grid-institutes:grid.416963.f schema:alternateName Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    389 schema:name Department of Pathology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    390 rdf:type schema:Organization
    391 grid-institutes:grid.417323.0 schema:alternateName Department of Surgery, Yamagata Prefectural Central Hospital, Yamagata, Japan
    392 schema:name Department of Surgery, Yamagata Prefectural Central Hospital, Yamagata, Japan
    393 rdf:type schema:Organization
    394 grid-institutes:grid.482675.a schema:alternateName Digestive Disease Center, Showa University, Northern Yokohama Hospital, Yokohama, Japan
    395 schema:name Digestive Disease Center, Showa University, Northern Yokohama Hospital, Yokohama, Japan
    396 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...