C-reactive protein is an indicator of serum infliximab level in predicting loss of response in patients with Crohn’s disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-04-20

AUTHORS

Toshifumi Hibi, Atsushi Sakuraba, Mamoru Watanabe, Satoshi Motoya, Hiroaki Ito, Noriko Sato, Toru Yoshinari, Kenta Motegi, Yoshitaka Kinouchi, Masakazu Takazoe, Yasuo Suzuki, Takayuki Matsumoto, Kazuhiko Kawakami, Takayuki Matsumoto, Ichiro Hirata, Shinji Tanaka, Toshifumi Ashida, Toshiyuki Matsui

ABSTRACT

BackgroundThe ability of serum infliximab level to predict clinical outcome in infliximab therapy in Crohn’s disease is unclear. Here, we aimed to clarify the correlation between the timing of loss of response (LOR) to treatment and a decrease in serum infliximab level, and, in addition, to identify an indicator of infliximab level.MethodsThe study used data from a previous clinical study of infliximab for Crohn’s disease, in which infliximab was initially given at 0, 2, 6 weeks at 5 mg/kg, and then at 8-week intervals to 62 week-10 responders. Of these 62, here we analysed data from 57 in whom Crohn’s disease activity index and serum infliximab level were evaluated at week 14.ResultsTwelve patients showed a clinical response despite an infliximab level <1 μg/mL at week 14; of these, 8 (67 %) experienced LOR by week 54. A decrease in infliximab level preceded LOR in 6 (75 %). In receiver operating characteristic curve analysis, C-reactive protein (CRP) showed better performance in detecting an infliximab level <1 μg/mL. Infliximab level was <1 μg/mL in 60–80 % of patients with CRP >0.5 mg/dL. Time to LOR (median: 22.0 weeks) was significantly longer than that to a decrease in infliximab level to <1 μg/mL (14.0 weeks, p < 0.05) or to an increase in CRP to >0.5 mg/dL (14.0 weeks, p < 0.01).ConclusionsA decrease in serum infliximab level preceded LOR, and was easily detected by an increase in CRP. The CRP may be an indicator of serum infliximab level in predicting LOR. More... »

PAGES

254-262

References to SciGraph publications

Journal

TITLE

Journal of Gastroenterology

ISSUE

2

VOLUME

49

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00535-013-0807-0

DOI

http://dx.doi.org/10.1007/s00535-013-0807-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002763593

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23604570


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28 schema:description BackgroundThe ability of serum infliximab level to predict clinical outcome in infliximab therapy in Crohn’s disease is unclear. Here, we aimed to clarify the correlation between the timing of loss of response (LOR) to treatment and a decrease in serum infliximab level, and, in addition, to identify an indicator of infliximab level.MethodsThe study used data from a previous clinical study of infliximab for Crohn’s disease, in which infliximab was initially given at 0, 2, 6 weeks at 5 mg/kg, and then at 8-week intervals to 62 week-10 responders. Of these 62, here we analysed data from 57 in whom Crohn’s disease activity index and serum infliximab level were evaluated at week 14.ResultsTwelve patients showed a clinical response despite an infliximab level <1 μg/mL at week 14; of these, 8 (67 %) experienced LOR by week 54. A decrease in infliximab level preceded LOR in 6 (75 %). In receiver operating characteristic curve analysis, C-reactive protein (CRP) showed better performance in detecting an infliximab level <1 μg/mL. Infliximab level was <1 μg/mL in 60–80 % of patients with CRP >0.5 mg/dL. Time to LOR (median: 22.0 weeks) was significantly longer than that to a decrease in infliximab level to <1 μg/mL (14.0 weeks, p < 0.05) or to an increase in CRP to >0.5 mg/dL (14.0 weeks, p < 0.01).ConclusionsA decrease in serum infliximab level preceded LOR, and was easily detected by an increase in CRP. The CRP may be an indicator of serum infliximab level in predicting LOR.
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