Long-term incidence and characteristics of intestinal failure in Crohn’s disease: a multicenter study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-04-07

AUTHORS

Kazuhiro Watanabe, Iwao Sasaki, Kouhei Fukushima, Kitaro Futami, Hiroki Ikeuchi, Akira Sugita, Riichiro Nezu, Tsunekazu Mizushima, Shingo Kameoka, Masato Kusunoki, Kazuhiko Yoshioka, Yuji Funayama, Toshiaki Watanabe, Hisao Fujii, Mamoru Watanabe

ABSTRACT

BackgroundThe aim of this study was to clarify the risk and characteristics of intestinal failure (IF) in patients with Crohn’s disease (CD).MethodsThe present study was a retrospective study in 12 hospitals. CD patients who underwent initial surgery at any of the 12 hospitals between 1970 and 2009 were collected (n = 1,703). Those who developed IF were reviewed (n = 68), and the cumulative risk of IF was analyzed by the Kaplan–Meier method. In addition, IF patients who underwent initial surgery at other hospitals and were then treated at any of the 12 hospitals were also reviewed (n = 33). Thus, a total of 101 IF patients were collected, and the cumulative risk of IF-related death was analyzed.ResultsThe cumulative risk of IF after the initial surgery was 0.8 % (5 years), 3.6 % (10 years), 6.1 % (15 years), and 8.5 % (20 years). In CD patients with IF, mean age at initial surgery, IF occurrence, and present age at the time of the study were 28.2, 38.2, and 46.1 years, respectively. The mean number of surgeries per patient was 3.3. The mean length of the remnant small bowel was 163 cm. Twelve IF patients (12 %) had died and the cumulative risk of IF-related death by the time from the occurrence of IF was 1.1 % (3 years), 3.7 % (5 years), 6.5 % (7 years), and 8.9 % (10 years).ConclusionThe occurrence of IF and IF-related death in CD patients is not rare over the long term. There is a pressing need to develop strategies for the prevention and management of IF. More... »

PAGES

231-238

References to SciGraph publications

  • 2009-10-27. The Natural History of Adult Crohn's Disease in Population-Based Cohorts in THE AMERICAN JOURNAL OF GASTROENTEROLOGY
  • Journal

    TITLE

    Journal of Gastroenterology

    ISSUE

    2

    VOLUME

    49

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s00535-013-0797-y

    DOI

    http://dx.doi.org/10.1007/s00535-013-0797-y

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1044827134

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/23564229


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        "description": "BackgroundThe aim of this study was to clarify the risk and characteristics of intestinal failure (IF) in patients with Crohn\u2019s disease (CD).MethodsThe present study was a retrospective study in 12 hospitals. CD patients who underwent initial surgery at any of the 12 hospitals between 1970 and 2009 were collected (n\u00a0=\u00a01,703). Those who developed IF were reviewed (n\u00a0=\u00a068), and the cumulative risk of IF was analyzed by the Kaplan\u2013Meier method. In addition, IF patients who underwent initial surgery at other hospitals and were then treated at any of the 12 hospitals were also reviewed (n\u00a0=\u00a033). Thus, a total of 101 IF patients were collected, and the cumulative risk of IF-related death was analyzed.ResultsThe cumulative risk of IF after the initial surgery was 0.8\u00a0% (5\u00a0years), 3.6\u00a0% (10\u00a0years), 6.1\u00a0% (15\u00a0years), and 8.5\u00a0% (20\u00a0years). In CD patients with IF, mean age at initial surgery, IF occurrence, and present age at the time of the study were 28.2, 38.2, and 46.1\u00a0years, respectively. The mean number of surgeries per patient was 3.3. The mean length of the remnant small bowel was 163\u00a0cm. Twelve IF patients (12\u00a0%) had died and the cumulative risk of IF-related death by the time from the occurrence of IF was 1.1\u00a0% (3\u00a0years), 3.7\u00a0% (5\u00a0years), 6.5\u00a0% (7\u00a0years), and 8.9\u00a0% (10\u00a0years).ConclusionThe occurrence of IF and IF-related death in CD patients is not rare over the long term. There is a pressing need to develop strategies for the prevention and management of IF.", 
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    24 schema:description BackgroundThe aim of this study was to clarify the risk and characteristics of intestinal failure (IF) in patients with Crohn’s disease (CD).MethodsThe present study was a retrospective study in 12 hospitals. CD patients who underwent initial surgery at any of the 12 hospitals between 1970 and 2009 were collected (n = 1,703). Those who developed IF were reviewed (n = 68), and the cumulative risk of IF was analyzed by the Kaplan–Meier method. In addition, IF patients who underwent initial surgery at other hospitals and were then treated at any of the 12 hospitals were also reviewed (n = 33). Thus, a total of 101 IF patients were collected, and the cumulative risk of IF-related death was analyzed.ResultsThe cumulative risk of IF after the initial surgery was 0.8 % (5 years), 3.6 % (10 years), 6.1 % (15 years), and 8.5 % (20 years). In CD patients with IF, mean age at initial surgery, IF occurrence, and present age at the time of the study were 28.2, 38.2, and 46.1 years, respectively. The mean number of surgeries per patient was 3.3. The mean length of the remnant small bowel was 163 cm. Twelve IF patients (12 %) had died and the cumulative risk of IF-related death by the time from the occurrence of IF was 1.1 % (3 years), 3.7 % (5 years), 6.5 % (7 years), and 8.9 % (10 years).ConclusionThe occurrence of IF and IF-related death in CD patients is not rare over the long term. There is a pressing need to develop strategies for the prevention and management of IF.
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