Metabolic markers and ALT cutoff level for diagnosing nonalcoholic fatty liver disease: a community-based cross-sectional study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-02-14

AUTHORS

Teruki Miyake, Teru Kumagi, Masashi Hirooka, Mitsuhito Koizumi, Shinya Furukawa, Teruhisa Ueda, Yoshio Tokumoto, Yoshio Ikeda, Masanori Abe, Kohichiro Kitai, Yoichi Hiasa, Bunzo Matsuura, Morikazu Onji

ABSTRACT

BackgroundUntreated nonalcoholic fatty liver disease (NAFLD) may progress to liver cirrhosis or failure and is associated with the development of hepatocellular carcinoma, diabetes, and cardiovascular disease. It is therefore essential to diagnose and treat NAFLD at an early stage. To assist in this effort, this retrospective study explored the risk factors for NAFLD, and derived new surrogates, a revised alanine aminotransferase (ALT) cutoff level and a novel NAFLD index, to identify previously undiagnosed cases of NAFLD.MethodsUsing a community-based, cross-sectional design, the records of 6,370 Japanese subjects who had undergone at least 1 annual health check-up were reviewed for the identification of subjects meeting the diagnostic criteria for NAFLD and the variables associated with NAFLD for the estimation of ideal ALT cutoff levels.ResultsThe results of multivariate analysis of the 1,346 subjects who met the diagnostic criteria for NAFLD confirmed that metabolic disease markers and a novel NAFLD index, using the variables derived from multivariate analysis, were also markers of NAFLD. The ALT cutoff levels for NAFLD diagnosis were estimated at 25 U/L for males and 17 U/L for females.ConclusionsALT level and the novel NAFLD index were confirmed to be surrogate markers for NAFLD in addition to metabolic disease markers. The ALT cutoff level used in NAFLD diagnosis should be revised downward to identify subjects at risk of NAFLD to prevent NAFLD progression and the development of associated diseases. More... »

PAGES

696-703

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00535-012-0534-y

DOI

http://dx.doi.org/10.1007/s00535-012-0534-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025763877

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22331365


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29 schema:description BackgroundUntreated nonalcoholic fatty liver disease (NAFLD) may progress to liver cirrhosis or failure and is associated with the development of hepatocellular carcinoma, diabetes, and cardiovascular disease. It is therefore essential to diagnose and treat NAFLD at an early stage. To assist in this effort, this retrospective study explored the risk factors for NAFLD, and derived new surrogates, a revised alanine aminotransferase (ALT) cutoff level and a novel NAFLD index, to identify previously undiagnosed cases of NAFLD.MethodsUsing a community-based, cross-sectional design, the records of 6,370 Japanese subjects who had undergone at least 1 annual health check-up were reviewed for the identification of subjects meeting the diagnostic criteria for NAFLD and the variables associated with NAFLD for the estimation of ideal ALT cutoff levels.ResultsThe results of multivariate analysis of the 1,346 subjects who met the diagnostic criteria for NAFLD confirmed that metabolic disease markers and a novel NAFLD index, using the variables derived from multivariate analysis, were also markers of NAFLD. The ALT cutoff levels for NAFLD diagnosis were estimated at 25 U/L for males and 17 U/L for females.ConclusionsALT level and the novel NAFLD index were confirmed to be surrogate markers for NAFLD in addition to metabolic disease markers. The ALT cutoff level used in NAFLD diagnosis should be revised downward to identify subjects at risk of NAFLD to prevent NAFLD progression and the development of associated diseases.
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35 schema:keywords Japanese subjects
36 NAFLD diagnosis
37 NAFLD index
38 NAFLD progression
39 ResultsThe results
40 addition
41 analysis
42 annual health
43 carcinoma
44 cardiovascular disease
45 cases
46 cirrhosis
47 community-based cross-sectional study
48 criteria
49 cross-sectional design
50 cross-sectional study
51 cutoff level
52 design
53 development
54 diabetes
55 diagnosis
56 diagnostic criteria
57 disease
58 disease markers
59 early stages
60 efforts
61 estimation
62 factors
63 failure
64 fatty liver disease
65 females
66 health
67 hepatocellular carcinoma
68 identification
69 identification of subjects
70 index
71 levels
72 liver cirrhosis
73 liver disease
74 males
75 markers
76 markers of NAFLD
77 metabolic disease markers
78 metabolic markers
79 multivariate analysis
80 new surrogate
81 nonalcoholic fatty liver disease
82 progression
83 records
84 results
85 retrospective study
86 risk
87 risk factors
88 risk of NAFLD
89 stage
90 study
91 subjects
92 surrogate
93 surrogate marker
94 undiagnosed cases
95 variables
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