Leukocytapheresis for steroid-dependent ulcerative colitis in clinical practice: results of a nationwide Spanish registry View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-11-23

AUTHORS

J. L. Cabriada, E. Domènech, N. Ibargoyen, V. Hernández, J. Clofent, D. Ginard, I. Gutiérrez-Ibarluzea, J. Hinojosa

ABSTRACT

BackgroundSeveral small, prospective, open studies suggest that leukocytapheresis might be efficient in patients with steroid-dependent ulcerative colitis (UC).AimTo evaluate the short- and long-term effectiveness of leukocytapheresis for the management of steroid-dependent UC in clinical practice.MethodsA Web-based, nationwide database specifically designed to record the efficacy and safety data of leukocytapheresis therapy in UC was available from September 2007 in Spain. Clinical data were collected at treatment baseline, 1 month after the last apheresis session (initial efficacy), and 6 and 12 months thereafter (long-term efficacy). Remission was defined as a Mayo Clinic index ≤2 together with complete steroid withdrawal and response as a decrease of ≥3 from the baseline score.ResultsA total of 142 steroid-dependent UC patients were included in the registry, most of them treated with the Adacolumn™ system. In 69% of patients thiopurine therapy failed to achieve steroid-free clinical remission. Initial clinical remission was obtained in 37% of cases. The initial corticosteroid dose, the number and frequency of apheresis sessions, or the previous failure of thiopurines and/or infliximab did not influence the initial remission rate, but a greater decrease in CRP levels was associated with a higher probability to obtain initial remission. At 6 and 12 months, 41 and 36% of patients were in clinical remission, respectively. Only one serious adverse effect was recorded.ConclusionsIn clinical practice, apheresis allows long-term steroid-free clinical remission in up to one third of steroid-dependent UC patients, even in those with prior failure of thiopurines. More... »

PAGES

359-365

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00535-011-0499-2

DOI

http://dx.doi.org/10.1007/s00535-011-0499-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048038145

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22105230


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