Characteristics of recurrence after curative resection for T1 colorectal cancer: Japanese multicenter study View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-12-09

AUTHORS

Hirotoshi Kobayashi, Hidetaka Mochizuki, Takayuki Morita, Kenjiro Kotake, Tatsuo Teramoto, Shingo Kameoka, Yukio Saito, Keiichi Takahashi, Kazuo Hase, Masatoshi Oya, Koutarou Maeda, Takashi Hirai, Masao Kameyama, Kazuo Shirouzu, Kenichi Sugihara

ABSTRACT

BackgroundBecause the rate of recurrence after curative resection for T1 colorectal cancer is low, the characteristics of recurrence remain obscure. This multicenter study attempted to clarify the characteristics of recurrence after curative resection for T1 colorectal cancer.MethodsWe analyzed the associations between recurrence and various clinicopathological features in 798 patients who had undergone curative resection alone for T1 colorectal cancer at 14 hospitals between 1991 and 1996.ResultsThe rate of lymph node metastasis (LNM) in patients with T1 colorectal cancer was 10.5% (84/798), and 18 (2.3%) of the 798 patients developed recurrence during the median follow-up of 7.8 years. The recurrence rates in patients with colon cancer with and without LNM were 3.6 and 1.3%, respectively (p = 0.19). These rates in patients with cancer of the rectum were 25.0 and 1.1% (p < 0.0001). Among various parameters, histological grade (p < 0.0001), location (p = 0.025), LNM (p < 0.0001), and venous invasion (p = 0.0013) were risk factors for recurrence. Among them, LNM (p = 0.0008) and histological grade (p = 0.041) were independent risk factors for recurrence after curative resection for T1 colorectal cancer. Time to recurrence was more likely to be shorter for patients with, than without nodal involvement. In patients with an unfavorable histological grade, all recurrences developed within 1 year.ConclusionsThe recurrence rate after curative resection for node-negative T1 colorectal cancer was very low. The effectiveness of surveillance to detect recurrence after curative resection for T1 colorectal cancer should be validated in further studies. More... »

PAGES

203-211

Journal

TITLE

Journal of Gastroenterology

ISSUE

2

VOLUME

46

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00535-010-0341-2

DOI

http://dx.doi.org/10.1007/s00535-010-0341-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024153447

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21152938


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33 schema:description BackgroundBecause the rate of recurrence after curative resection for T1 colorectal cancer is low, the characteristics of recurrence remain obscure. This multicenter study attempted to clarify the characteristics of recurrence after curative resection for T1 colorectal cancer.MethodsWe analyzed the associations between recurrence and various clinicopathological features in 798 patients who had undergone curative resection alone for T1 colorectal cancer at 14 hospitals between 1991 and 1996.ResultsThe rate of lymph node metastasis (LNM) in patients with T1 colorectal cancer was 10.5% (84/798), and 18 (2.3%) of the 798 patients developed recurrence during the median follow-up of 7.8 years. The recurrence rates in patients with colon cancer with and without LNM were 3.6 and 1.3%, respectively (p = 0.19). These rates in patients with cancer of the rectum were 25.0 and 1.1% (p < 0.0001). Among various parameters, histological grade (p < 0.0001), location (p = 0.025), LNM (p < 0.0001), and venous invasion (p = 0.0013) were risk factors for recurrence. Among them, LNM (p = 0.0008) and histological grade (p = 0.041) were independent risk factors for recurrence after curative resection for T1 colorectal cancer. Time to recurrence was more likely to be shorter for patients with, than without nodal involvement. In patients with an unfavorable histological grade, all recurrences developed within 1 year.ConclusionsThe recurrence rate after curative resection for node-negative T1 colorectal cancer was very low. The effectiveness of surveillance to detect recurrence after curative resection for T1 colorectal cancer should be validated in further studies.
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41 ConclusionsThe recurrence rate
42 Further studies
43 Japanese multicenter study
44 MethodsWe
45 T1 colorectal cancer
46 association
47 cancer
48 characteristics
49 characteristics of recurrence
50 clinicopathological features
51 colon cancer
52 colorectal cancer
53 curative resection
54 effectiveness
55 effectiveness of surveillance
56 factors
57 features
58 grade
59 histological grade
60 hospital
61 independent risk factor
62 invasion
63 involvement
64 location
65 lymph node metastasis
66 metastasis
67 multicenter study
68 nodal involvement
69 node metastasis
70 node-negative T1 colorectal cancer
71 parameters
72 patients
73 rate
74 rate of recurrence
75 rectum
76 recurrence
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78 resection
79 risk factors
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