Ontology type: schema:ScholarlyArticle
2010-07-24
AUTHORSHyohun Park, Toshihide Shima, Kanji Yamaguchi, Hironori Mitsuyoshi, Masahito Minami, Kohichiroh Yasui, Yoshito Itoh, Toshikazu Yoshikawa, Michiaki Fukui, Goji Hasegawa, Naoto Nakamura, Mitsuhiro Ohta, Hiroshi Obayashi, Takeshi Okanoue
ABSTRACTBackgroundHyperlipidemia, insulin resistance, and oxidative stress can heavily contribute to the initiation and progression of nonalcoholic fatty liver disease (NAFLD). Currently, there is no established treatment for this disease. Recently, several studies have shown that ezetimibe (EZ), a lipid-lowering drug, attenuates liver steatosis in an experimental NAFLD model. This study was designed to assess the efficacy of long-term EZ monotherapy in patients with NAFLD.MethodsA total of 45 patients with newly diagnosed liver biopsy-proven NAFLD were treated with EZ (10 mg/day) for 24 months. NAFLD-related biochemical parameters, imaging by computerized tomography, and liver biopsy were studied before and after treatment.ResultsEzetimibe therapy significantly improved NAFLD-related metabolic parameters including visceral fat area, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-R), triglycerides, total cholesterol, low-density lipoprotein cholesterol (LDL-Ch), oxidative-LDL, the net electronegative charge modified-LDL, profiles of lipoprotein particle size and fatty acids component, and estimated desaturase activity. EZ therapy also significantly lowered serum alanine aminotransferase and high-sensitivity C-reactive protein levels, whereas no significant changes were found in serum type IV collagen 7S, adiponectin, leptin, and resistin levels. Histological features of steatosis grade (P = 0.0003), necroinflammatory grade (P = 0.0456), ballooning score (P = 0.0253), and NAFLD activity score (NAS) (P = 0.0007) were significantly improved from baseline. However, the fibrosis stage was not significantly (P = 0.6547) changed.ConclusionThe results in this study suggest that the long-term EZ therapy can lead to improvement in metabolic, biochemical, and histological abnormalities of NAFLD. Therefore, EZ may be a promising agent for treatment of NAFLD. More... »
PAGES101-107
http://scigraph.springernature.com/pub.10.1007/s00535-010-0291-8
DOIhttp://dx.doi.org/10.1007/s00535-010-0291-8
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1015346058
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/20658156
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Anticholesteremic Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Azetidines",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biomarkers",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Biopsy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug Administration Schedule",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Ezetimibe",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Fatty Liver",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Liver",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Liver Cirrhosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Non-alcoholic Fatty Liver Disease",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Treatment Outcome",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan",
"id": "http://www.grid.ac/institutes/grid.272458.e",
"name": [
"Department of Gastroenterology and Hepatology, Saiseikai Suita Hospital, 1-2 Kawazono-cho, 564-0013, Suita, Osaka, Japan",
"Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Park",
"givenName": "Hyohun",
"id": "sg:person.01070501073.17",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01070501073.17"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Gastroenterology and Hepatology, Saiseikai Suita Hospital, 1-2 Kawazono-cho, 564-0013, Suita, Osaka, Japan",
"id": "http://www.grid.ac/institutes/grid.416633.5",
"name": [
"Department of Gastroenterology and Hepatology, Saiseikai Suita Hospital, 1-2 Kawazono-cho, 564-0013, Suita, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Shima",
"givenName": "Toshihide",
"id": "sg:person.01305103717.77",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01305103717.77"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan",
"id": "http://www.grid.ac/institutes/grid.272458.e",
"name": [
"Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Yamaguchi",
"givenName": "Kanji",
"id": "sg:person.01323343532.68",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01323343532.68"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan",
"id": "http://www.grid.ac/institutes/grid.272458.e",
"name": [
"Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Mitsuyoshi",
"givenName": "Hironori",
"id": "sg:person.0655753412.37",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0655753412.37"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan",
"id": "http://www.grid.ac/institutes/grid.272458.e",
"name": [
"Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Minami",
"givenName": "Masahito",
"id": "sg:person.01004571343.96",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01004571343.96"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan",
"id": "http://www.grid.ac/institutes/grid.272458.e",
"name": [
"Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Yasui",
"givenName": "Kohichiroh",
"id": "sg:person.014564566442.18",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014564566442.18"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan",
"id": "http://www.grid.ac/institutes/grid.272458.e",
"name": [
"Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Itoh",
"givenName": "Yoshito",
"id": "sg:person.01017130226.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01017130226.32"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan",
"id": "http://www.grid.ac/institutes/grid.272458.e",
"name": [
"Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Yoshikawa",
"givenName": "Toshikazu",
"id": "sg:person.01126013224.75",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01126013224.75"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan",
"id": "http://www.grid.ac/institutes/grid.272458.e",
"name": [
"Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Fukui",
"givenName": "Michiaki",
"id": "sg:person.016357516722.38",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016357516722.38"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan",
"id": "http://www.grid.ac/institutes/grid.272458.e",
"name": [
"Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Hasegawa",
"givenName": "Goji",
"id": "sg:person.01162763674.43",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162763674.43"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan",
"id": "http://www.grid.ac/institutes/grid.272458.e",
"name": [
"Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Nakamura",
"givenName": "Naoto",
"id": "sg:person.0677442163.58",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0677442163.58"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Medical Biochemistry, Kobe Pharmaceutical University, Kobe, Japan",
"id": "http://www.grid.ac/institutes/grid.411100.5",
"name": [
"Department of Medical Biochemistry, Kobe Pharmaceutical University, Kobe, Japan"
],
"type": "Organization"
},
"familyName": "Ohta",
"givenName": "Mitsuhiro",
"id": "sg:person.01127077703.44",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127077703.44"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Molecular Biochemistry, Institute of Bio-Response Informatics, Kyoto, Japan",
"id": "http://www.grid.ac/institutes/None",
"name": [
"Department of Molecular Biochemistry, Institute of Bio-Response Informatics, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Obayashi",
"givenName": "Hiroshi",
"id": "sg:person.01114650474.20",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01114650474.20"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan",
"id": "http://www.grid.ac/institutes/grid.272458.e",
"name": [
"Department of Gastroenterology and Hepatology, Saiseikai Suita Hospital, 1-2 Kawazono-cho, 564-0013, Suita, Osaka, Japan",
"Department of Molecular Gastroenterology and Hepatology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"
],
"type": "Organization"
},
"familyName": "Okanoue",
"givenName": "Takeshi",
"id": "sg:person.0620055423.88",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620055423.88"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1111/j.1572-0241.2005.41583.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049736431",
"https://doi.org/10.1111/j.1572-0241.2005.41583.x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1111/j.1572-0241.1999.01377.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015032643",
"https://doi.org/10.1111/j.1572-0241.1999.01377.x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00125-005-0125-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004133181",
"https://doi.org/10.1007/s00125-005-0125-z"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00125-007-0790-1",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003650690",
"https://doi.org/10.1007/s00125-007-0790-1"
],
"type": "CreativeWork"
}
],
"datePublished": "2010-07-24",
"datePublishedReg": "2010-07-24",
"description": "BackgroundHyperlipidemia, insulin resistance, and oxidative stress can heavily contribute to the initiation and progression of nonalcoholic fatty liver disease (NAFLD). Currently, there is no established treatment for this disease. Recently, several studies have shown that ezetimibe (EZ), a lipid-lowering drug, attenuates liver steatosis in an experimental NAFLD model. This study was designed to assess the efficacy of long-term EZ monotherapy in patients with NAFLD.MethodsA total of 45 patients with newly diagnosed liver biopsy-proven NAFLD were treated with EZ (10\u00a0mg/day) for 24\u00a0months. NAFLD-related biochemical parameters, imaging by computerized tomography, and liver biopsy were studied before and after treatment.ResultsEzetimibe therapy significantly improved NAFLD-related metabolic parameters including visceral fat area, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-R), triglycerides, total cholesterol, low-density lipoprotein cholesterol (LDL-Ch), oxidative-LDL, the net electronegative charge modified-LDL, profiles of lipoprotein particle size and fatty acids component, and estimated desaturase activity. EZ therapy also significantly lowered serum alanine aminotransferase and high-sensitivity C-reactive protein levels, whereas no significant changes were found in serum type IV collagen 7S, adiponectin, leptin, and resistin levels. Histological features of steatosis grade (P\u00a0=\u00a00.0003), necroinflammatory grade (P\u00a0=\u00a00.0456), ballooning score (P\u00a0=\u00a00.0253), and NAFLD activity score (NAS) (P\u00a0=\u00a00.0007) were significantly improved from baseline. However, the fibrosis stage was not significantly (P\u00a0=\u00a00.6547) changed.ConclusionThe results in this study suggest that the long-term EZ therapy can lead to improvement in metabolic, biochemical, and histological abnormalities of NAFLD. Therefore, EZ may be a promising agent for treatment of NAFLD.",
"genre": "article",
"id": "sg:pub.10.1007/s00535-010-0291-8",
"inLanguage": "en",
"isAccessibleForFree": false,
"isFundedItemOf": [
{
"id": "sg:grant.6064079",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1009747",
"issn": [
"0944-1174",
"1435-5922"
],
"name": "Journal of Gastroenterology",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "46"
}
],
"keywords": [
"nonalcoholic fatty liver disease",
"NAFLD activity score",
"fatty liver disease",
"liver disease",
"insulin resistance",
"liver biopsy-proven nonalcoholic fatty liver disease",
"biopsy-proven nonalcoholic fatty liver disease",
"treatment of NAFLD",
"serum type IV collagen 7S",
"type IV collagen 7S",
"low-density lipoprotein cholesterol",
"visceral fat area",
"reactive protein levels",
"homeostasis model assessment",
"lipid-lowering drugs",
"serum alanine aminotransferase",
"lipoprotein particle size",
"collagen 7S",
"ballooning scores",
"NAFLD model",
"ezetimibe therapy",
"lipoprotein cholesterol",
"resistin levels",
"necroinflammatory grade",
"liver biopsy",
"total cholesterol",
"liver steatosis",
"steatosis grade",
"activity score",
"fat area",
"histological features",
"fibrosis stage",
"histological abnormalities",
"metabolic parameters",
"alanine aminotransferase",
"model assessment",
"computerized tomography",
"net electronegative charge",
"therapy",
"ezetimibe",
"promising agent",
"patients",
"biochemical parameters",
"oxidative stress",
"disease",
"protein levels",
"desaturase activity",
"LDL",
"treatment",
"cholesterol",
"significant changes",
"efficacy",
"scores",
"fatty acid components",
"electronegative charge",
"BackgroundHyperlipidemia",
"monotherapy",
"steatosis",
"adiponectin",
"grade",
"biopsy",
"leptin",
"triglycerides",
"abnormalities",
"insulin",
"aminotransferase",
"baseline",
"progression",
"study",
"months",
"drugs",
"tomography",
"levels",
"total",
"resistance",
"initiation",
"agents",
"acid components",
"biochemical",
"assessment",
"activity",
"improvement",
"changes",
"profile",
"stage",
"stress",
"area",
"features",
"results",
"parameters",
"components",
"size",
"model",
"particle size",
"charge"
],
"name": "Efficacy of long-term ezetimibe therapy in patients with nonalcoholic fatty liver disease",
"pagination": "101-107",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1015346058"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s00535-010-0291-8"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"20658156"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s00535-010-0291-8",
"https://app.dimensions.ai/details/publication/pub.1015346058"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-10T10:03",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220509/entities/gbq_results/article/article_520.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s00535-010-0291-8"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s00535-010-0291-8'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s00535-010-0291-8'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s00535-010-0291-8'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s00535-010-0291-8'
This table displays all metadata directly associated to this object as RDF triples.
342 TRIPLES
22 PREDICATES
141 URIs
129 LITERALS
23 BLANK NODES