Detection of desmoplastic reaction in biopsy specimens is useful for predicting the depth of invasion of early colorectal cancer: a ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-07-28

AUTHORS

Motohiko Hirose, Hirokazu Fukui, Yoshinori Igarashi, Yukari Fujimori, Yoshinori Katake, Akira Sekikawa, Kazuhito Ichikawa, Shigeki Tomita, Johji Imura, Yoichi Ajioka, Hideki Ueno, Kazuo Hase, Yasuo Ohkura, Hiroshi Kashida, Kazutomo Togashi, Takashi Nishigami, Toshiyuki Matsui, Takashi Yao, Ryo Wada, Keiji Matsuda, Toshiaki Watanabe, Atsushi Ochiai, Tamotsu Sugai, Kenichi Sugihara, Takahiro Fujimori

ABSTRACT

BackgroundWe have previously demonstrated a relationship between the depth of submucosal invasion (SM depth) and the frequency of lymph node metastasis in resected submucosal invasive colorectal cancers (SICRCs). Here, we assessed the desmoplastic reaction (DR) in pretreatment biopsy specimens of SICRC to predict the SM depth.MethodsA total of 359 patients with SICRCs, who had undergone surgical or endoscopic mucosal resection, were enrolled. The SM depth of the SICRC lesions was evaluated according to the procedure established by the Japanese Society for Cancer of the Colon and Rectum, and the patients’ corresponding pretreatment biopsy specimens were examined histologically to evaluate the prevalence of DR.ResultsFor pedunculated SICRCs, the prevalence of DR in pretreatment biopsy specimens was significantly higher in moderately differentiated than in well-differentiated adenocarcinomas, but was not significantly related to SM depth. For nonpedunculated SICRCs, the prevalence of DR in pretreatment biopsy specimens was significantly related to histological type, tumor size, and SM depth. When non-pedunculated SICRCs were further divided using a specific cutoff value of 1000 μm for SM depth, the DR positivity rate in pretreatment biopsy specimens was significantly higher in SICRCs with an SM depth of ≧1000 μm (termed “SM massive CRCs”) than in cases where the SM depth was <1000 μm (termed “SM slight CRCs”).ConclusionsDetection of DR in pretreatment biopsy specimens is useful for the prediction of SM depth in nonpedunculated SICRCs, and may be useful for the selection of such cases that would be treatable by endoscopic mucosal resection and endoscopic submucosal dissection (EMR/ESD). More... »

PAGES

1212-1218

Journal

TITLE

Journal of Gastroenterology

ISSUE

12

VOLUME

45

Author Affiliations

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s00535-010-0288-3

DOI

http://dx.doi.org/10.1007/s00535-010-0288-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1015440126

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20665053


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